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- W2743282786 abstract "Background: Some studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD. Methods: 22 patients received doses of 4000 and 10000 IU/day of cholecalciferol for 12 weeks according to patient’s previous VD levels. They were submitted to continuous glucose monitoring system (CGMS), 24-h ABPM and urine albumin-to-creatinine ratio (UACR) before and after VD supplementation. Results: There was a reduction of DKD prevalence at the end of the study (68% vs 32%; p=0.05), with no changes on insulin doses, HbA1c, glycemic variability (GV) and blood pressure (BP) values. A correlation between percentage variation of VD levels (∆VD) and albuminuria at the end of the study was presented (r= -0.5; p <0.05). Among T1DM patients with DKD at the beginning of the study, 8/13 (62%) had their DKD stage improved, while the other five ones (38%) showed no changes (p <0.05). Conclusions: Our pilot study suggests an association between VD high dose supplementation, lower prevalence and improvement in stages of DKD in T1DM." @default.
- W2743282786 created "2017-08-17" @default.
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- W2743282786 date "2017-08-14" @default.
- W2743282786 modified "2023-10-01" @default.
- W2743282786 title "Albuminuria Reduction after High Dose of Vitamin D in Patients with Type 1 Diabetes Mellitus: A Pilot Study" @default.
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- W2743282786 doi "https://doi.org/10.3389/fendo.2017.00199" @default.
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