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- W2743283347 endingPage "58" @default.
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- W2743283347 abstract "This chapter analyzes the nature and distribution of inherited antibody genes by probing the germline, and studies developmentally regulated changes in these antibody genes by probing different stages in the differentiation of normal B lymphocytes. Immunoglobulin gene rearrangements during B lymphocyte differentiation activate expression of a particular immunoglobulin gene in an antigen-independent process. During the antigen-dependent phase of lymphocyte maturation, antibody molecules of different isotypes with the same antigen-binding specificity are produced in progenies of the same virgin B lymphocyte. This process of heavy chain switch is mediated by another form of immunoglobulin gene rearrangements. Immunoglobulin molecules consist of multiple, homologous domains, each about 110 amino acid residues in length. It is likely that a primordial immunoglobulin domain gene existed a t some point in evolution. This gene must have been duplicated several times and the resulting copies were organized in three multigene families (kappa, lambda, and heavy chains) located on three different chromosomes. In the mouse there are at least another three, superficially unrelated gene products that show significant homology to the immunoglobulin domain." @default.
- W2743283347 created "2017-08-17" @default.
- W2743283347 creator A5069074989 @default.
- W2743283347 creator A5071188525 @default.
- W2743283347 creator A5082174975 @default.
- W2743283347 creator A5082894731 @default.
- W2743283347 date "1983-01-01" @default.
- W2743283347 modified "2023-09-25" @default.
- W2743283347 title "Chapter 2 Immunoglobulin Gene Rearrangement and Expression During Lymphocyte Development" @default.
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