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• W2743287907 abstract "This review discusses novel immunotherapeutic approaches to treat Hodgkin lymphoma (HL), specifically PD-1 inhibitors and cellular immunotherapy. PD-1 inhibitors have shown promising results in the treatment of relapsed or refractory HL, leading to FDA approval of nivolumab and pembrolizumab, although complete remissions are rare. Chimeric antigen receptor T cells directed against CD30 have been investigated with preliminary clinical trials showing minimal toxicities and some responses in heavily pre-treated patients with HL. HL is unique as it consists of a small percentage of malignant cells (Hodgkin Reed Sternberg cells) surrounded by an inflammatory microenvironment which promotes tumor growth and suppresses immune responses, making it an ideal target for immunotherapeutic approaches, such as PD-1 inhibitors and cellular immunotherapy. Current research is focused on overcoming barriers to efficacy via rational combinations that overcome resistance to therapy." @default.
• W2743287907 created "2017-08-17" @default.
• W2743287907 creator A5065544223 @default.
• W2743287907 creator A5075085884 @default.
• W2743287907 date "2017-08-01" @default.
• W2743287907 modified "2023-09-26" @default.
• W2743287907 title "Targeting Immune System Alterations in Hodgkin Lymphoma" @default.
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• W2743287907 doi "https://doi.org/10.1007/s11899-017-0398-6" @default.
• W2743287907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7593851" @default.
• W2743287907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28780614" @default.
• W2743287907 hasPublicationYear "2017" @default.
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