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- W2743294627 abstract "Blood-brain barrier pathology is recognised as a central factor in the development of many neurological disorders, but much less is known about the role of the blood-brain barrier in psychiatric disorders. We review post-mortem, serum-biomarker, CSF-biomarker, and neuroimaging studies that have examined blood-brain barrier structure and function in schizophrenia and related psychoses. We consider how blood-brain barrier dysfunction could relate to glutamatergic and inflammatory abnormalities, which are increasingly understood to play a part in the pathogenesis of psychosis. Mechanisms by which the blood-brain barrier and its associated solute transporters moderate CNS availability of antipsychotic drugs are summarised. We conclude that the complex nature of blood-brain barrier dysfunction in psychosis might be relevant to many aspects of disrupted neuronal and synaptic function, increased permeability to inflammatory molecules, disrupted glutamate homoeostasis, impaired action of antipsychotics, and development of antipsychotic resistance. Future research should address the longitudinal course of blood-brain barrier alterations in psychosis, to determine whether blood-brain barrier dysfunction is a cause or consequence of the pathology associated with the disorder." @default.
- W2743294627 created "2017-08-17" @default.
- W2743294627 creator A5011682364 @default.
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- W2743294627 creator A5050129474 @default.
- W2743294627 creator A5053590250 @default.
- W2743294627 creator A5084314803 @default.
- W2743294627 date "2018-01-01" @default.
- W2743294627 modified "2023-10-16" @default.
- W2743294627 title "The blood–brain barrier in psychosis" @default.
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