FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743297970> ?p ?o ?g. }

• W2743297970 endingPage "1613" @default.
• W2743297970 startingPage "1603" @default.
• W2743297970 abstract "The long-lived, hypoxic-tolerant naked mole-rat well-maintains cardiac function over its three-decade-long lifespan and exhibits many cardiac features atypical of similar-sized laboratory rodents. For example, they exhibit low heart rates and resting cardiac contractility, yet have a large cardiac reserve. These traits are considered ecophysiological adaptations to their dank subterranean atmosphere of low oxygen and high carbon dioxide levels and may also contribute to negligible declines in cardiac function during aging. We asked if naked mole-rats had a different myofilament protein signature to that of similar-sized mice that commonly show both high heart rates and high basal cardiac contractility. Adult mouse ventricles predominantly expressed α-myosin heavy chain (97.9 ± 0.4%). In contrast, and more in keeping with humans, β myosin heavy chain was the dominant isoform (79.0 ± 2.0%) in naked mole-rat ventricles. Naked mole-rat ventricles diverged from those of both humans and mice, as they expressed both cardiac and slow skeletal isoforms of troponin I. This myofilament protein profile is more commonly observed in mice in utero and during cardiomyopathies. There were no species differences in phosphorylation of cardiac myosin binding protein-C or troponin I. Phosphorylation of both ventricular myosin light chain 2 and cardiac troponin T in naked mole-rats was approximately half that observed in mice. Myofilament function was also compared between the two species using permeabilized cardiomyocytes. Together, these data suggest a cardiac myofilament protein signature that may contribute to the naked mole-rat's suite of adaptations to its natural subterranean habitat." @default.
• W2743297970 created "2017-08-17" @default.
• W2743297970 creator A5005466573 @default.
• W2743297970 creator A5034153649 @default.
• W2743297970 creator A5041881945 @default.
• W2743297970 creator A5047094607 @default.
• W2743297970 creator A5047224964 @default.
• W2743297970 creator A5056694490 @default.
• W2743297970 creator A5090210734 @default.
• W2743297970 creator A5091108341 @default.
• W2743297970 date "2017-08-05" @default.
• W2743297970 modified "2023-10-15" @default.
• W2743297970 title "The naked mole-rat exhibits an unusual cardiac myofilament protein profile providing new insights into heart function of this naturally subterranean rodent" @default.
• W2743297970 cites W1482905052 @default.
• W2743297970 cites W1488056099 @default.
• W2743297970 cites W1566940064 @default.
• W2743297970 cites W1568783784 @default.
• W2743297970 cites W1867217399 @default.
• W2743297970 cites W1939277705 @default.
• W2743297970 cites W1979622294 @default.
• W2743297970 cites W1980527344 @default.
• W2743297970 cites W1983511446 @default.
• W2743297970 cites W1983883185 @default.
• W2743297970 cites W1988534875 @default.
• W2743297970 cites W1990242715 @default.
• W2743297970 cites W1992084236 @default.
• W2743297970 cites W1994536141 @default.
• W2743297970 cites W2001172802 @default.
• W2743297970 cites W2002621000 @default.
• W2743297970 cites W2007230556 @default.
• W2743297970 cites W2008675674 @default.
• W2743297970 cites W2017514802 @default.
• W2743297970 cites W2027759264 @default.
• W2743297970 cites W2035373517 @default.
• W2743297970 cites W2037392492 @default.
• W2743297970 cites W2054603530 @default.
• W2743297970 cites W2061889878 @default.
• W2743297970 cites W2063526462 @default.
• W2743297970 cites W2065756643 @default.
• W2743297970 cites W2073447787 @default.
• W2743297970 cites W2074433977 @default.
• W2743297970 cites W2079498453 @default.
• W2743297970 cites W2081524051 @default.
• W2743297970 cites W2084708493 @default.
• W2743297970 cites W2085228375 @default.
• W2743297970 cites W2086614100 @default.
• W2743297970 cites W2093663881 @default.
• W2743297970 cites W2098548847 @default.
• W2743297970 cites W2099302775 @default.
• W2743297970 cites W2105274063 @default.
• W2743297970 cites W2108872949 @default.
• W2743297970 cites W2129906012 @default.
• W2743297970 cites W2130516476 @default.
• W2743297970 cites W2150577572 @default.
• W2743297970 cites W2150788617 @default.
• W2743297970 cites W2151366816 @default.
• W2743297970 cites W2153041116 @default.
• W2743297970 cites W2165912888 @default.
• W2743297970 cites W2167489666 @default.
• W2743297970 cites W2169648778 @default.
• W2743297970 cites W2268833677 @default.
• W2743297970 cites W2275593872 @default.
• W2743297970 cites W2348664324 @default.
• W2743297970 cites W2462860152 @default.
• W2743297970 cites W2606455791 @default.
• W2743297970 doi "https://doi.org/10.1007/s00424-017-2046-3" @default.
• W2743297970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5856255" @default.
• W2743297970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28780592" @default.
• W2743297970 hasPublicationYear "2017" @default.
• W2743297970 type Work @default.
• W2743297970 sameAs 2743297970 @default.
• W2743297970 citedByCount "18" @default.
• W2743297970 countsByYear W27432979702018 @default.
• W2743297970 countsByYear W27432979702019 @default.
• W2743297970 countsByYear W27432979702020 @default.
• W2743297970 countsByYear W27432979702021 @default.
• W2743297970 countsByYear W27432979702022 @default.
• W2743297970 countsByYear W27432979702023 @default.
• W2743297970 crossrefType "journal-article" @default.
• W2743297970 hasAuthorship W2743297970A5005466573 @default.
• W2743297970 hasAuthorship W2743297970A5034153649 @default.
• W2743297970 hasAuthorship W2743297970A5041881945 @default.
• W2743297970 hasAuthorship W2743297970A5047094607 @default.
• W2743297970 hasAuthorship W2743297970A5047224964 @default.
• W2743297970 hasAuthorship W2743297970A5056694490 @default.
• W2743297970 hasAuthorship W2743297970A5090210734 @default.
• W2743297970 hasAuthorship W2743297970A5091108341 @default.
• W2743297970 hasBestOaLocation W27432979702 @default.
• W2743297970 hasConcept C111566952 @default.
• W2743297970 hasConcept C115725540 @default.
• W2743297970 hasConcept C124815738 @default.
• W2743297970 hasConcept C126322002 @default.
• W2743297970 hasConcept C134018914 @default.
• W2743297970 hasConcept C174054327 @default.
• W2743297970 hasConcept C2778198053 @default.
• W2743297970 hasConcept C36036425 @default.
• W2743297970 hasConcept C39133596 @default.
• W2743297970 hasConcept C500558357 @default.

• next