Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743390135> ?p ?o ?g. }
- W2743390135 endingPage "3562" @default.
- W2743390135 startingPage "3545" @default.
- W2743390135 abstract "Alteration of podocyte behavior is critically involved in the development and progression of many forms of human glomerular diseases. The molecular mechanisms that control podocyte behavior, however, are not well understood. Here, we investigated the role of Kindlin-2, a component of cell-matrix adhesions, in podocyte behavior in vivo . Ablation of Kindlin-2 in podocytes resulted in alteration of actin cytoskeletal organization, reduction of the levels of slit diaphragm proteins, effacement of podocyte foot processes, and ultimately massive proteinuria and death due to kidney failure. Through proteomic analyses and in vitro coimmunoprecipitation experiments, we identified Rho GDP-dissociation inhibitor α (RhoGDI α ) as a Kindlin-2–associated protein. Loss of Kindlin-2 in podocytes significantly reduced the expression of RhoGDI α and resulted in the dissociation of Rac1 from RhoGDI α , leading to Rac1 hyperactivation and increased motility of podocytes. Inhibition of Rac1 activation effectively suppressed podocyte motility and alleviated the podocyte defects and proteinuria induced by the loss of Kindlin-2 in vivo . Our results identify a novel Kindlin-2–RhoGDI α –Rac1 signaling axis that is critical for regulation of podocyte structure and function in vivo and provide evidence that it may serve as a useful target for therapeutic control of podocyte injury and associated glomerular diseases." @default.
- W2743390135 created "2017-08-17" @default.
- W2743390135 creator A5002663710 @default.
- W2743390135 creator A5016838955 @default.
- W2743390135 creator A5018355628 @default.
- W2743390135 creator A5026360359 @default.
- W2743390135 creator A5027110921 @default.
- W2743390135 creator A5039313839 @default.
- W2743390135 creator A5042198084 @default.
- W2743390135 creator A5043349197 @default.
- W2743390135 creator A5049554724 @default.
- W2743390135 creator A5062604671 @default.
- W2743390135 creator A5064246539 @default.
- W2743390135 creator A5069877503 @default.
- W2743390135 creator A5072793694 @default.
- W2743390135 creator A5080698941 @default.
- W2743390135 creator A5089856976 @default.
- W2743390135 date "2017-08-04" @default.
- W2743390135 modified "2023-10-15" @default.
- W2743390135 title "Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury" @default.
- W2743390135 cites W1597344058 @default.
- W2743390135 cites W1820889700 @default.
- W2743390135 cites W1874244373 @default.
- W2743390135 cites W1957808694 @default.
- W2743390135 cites W1963926156 @default.
- W2743390135 cites W1968115910 @default.
- W2743390135 cites W1975210330 @default.
- W2743390135 cites W1987073410 @default.
- W2743390135 cites W1998740840 @default.
- W2743390135 cites W1998899802 @default.
- W2743390135 cites W2002340857 @default.
- W2743390135 cites W2008718488 @default.
- W2743390135 cites W2011804090 @default.
- W2743390135 cites W2012008369 @default.
- W2743390135 cites W2014886554 @default.
- W2743390135 cites W2018639433 @default.
- W2743390135 cites W2024896486 @default.
- W2743390135 cites W2026465178 @default.
- W2743390135 cites W2028235817 @default.
- W2743390135 cites W2028305453 @default.
- W2743390135 cites W2039453220 @default.
- W2743390135 cites W2046966521 @default.
- W2743390135 cites W2053943711 @default.
- W2743390135 cites W2054954966 @default.
- W2743390135 cites W2058583297 @default.
- W2743390135 cites W2059264239 @default.
- W2743390135 cites W2059946666 @default.
- W2743390135 cites W2074867744 @default.
- W2743390135 cites W2075323044 @default.
- W2743390135 cites W2078673440 @default.
- W2743390135 cites W2088741178 @default.
- W2743390135 cites W2096286283 @default.
- W2743390135 cites W2101197058 @default.
- W2743390135 cites W2103777275 @default.
- W2743390135 cites W2107766793 @default.
- W2743390135 cites W2118357046 @default.
- W2743390135 cites W2121908444 @default.
- W2743390135 cites W2122240619 @default.
- W2743390135 cites W2122261044 @default.
- W2743390135 cites W2131309206 @default.
- W2743390135 cites W2135294680 @default.
- W2743390135 cites W2138002856 @default.
- W2743390135 cites W2138625930 @default.
- W2743390135 cites W2141664507 @default.
- W2743390135 cites W2142685635 @default.
- W2743390135 cites W2145598575 @default.
- W2743390135 cites W2146559746 @default.
- W2743390135 cites W2148062709 @default.
- W2743390135 cites W2154801237 @default.
- W2743390135 cites W2159437476 @default.
- W2743390135 cites W2161379424 @default.
- W2743390135 cites W2164934883 @default.
- W2743390135 cites W2168450345 @default.
- W2743390135 cites W2169811294 @default.
- W2743390135 cites W2232088318 @default.
- W2743390135 cites W2293895376 @default.
- W2743390135 cites W2316278724 @default.
- W2743390135 cites W2321866757 @default.
- W2743390135 cites W771030118 @default.
- W2743390135 doi "https://doi.org/10.1681/asn.2016091021" @default.
- W2743390135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5698060" @default.
- W2743390135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28775002" @default.
- W2743390135 hasPublicationYear "2017" @default.
- W2743390135 type Work @default.
- W2743390135 sameAs 2743390135 @default.
- W2743390135 citedByCount "37" @default.
- W2743390135 countsByYear W27433901352018 @default.
- W2743390135 countsByYear W27433901352019 @default.
- W2743390135 countsByYear W27433901352020 @default.
- W2743390135 countsByYear W27433901352021 @default.
- W2743390135 countsByYear W27433901352022 @default.
- W2743390135 countsByYear W27433901352023 @default.
- W2743390135 crossrefType "journal-article" @default.
- W2743390135 hasAuthorship W2743390135A5002663710 @default.
- W2743390135 hasAuthorship W2743390135A5016838955 @default.
- W2743390135 hasAuthorship W2743390135A5018355628 @default.
- W2743390135 hasAuthorship W2743390135A5026360359 @default.
- W2743390135 hasAuthorship W2743390135A5027110921 @default.