FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743402721> ?p ?o ?g. }

• W2743402721 endingPage "224" @default.
• W2743402721 startingPage "214" @default.
• W2743402721 abstract "Histone deacetylase (HDAC) inhibitors prevent neural cell death in in vivo models of cerebral ischaemia, brain injury and neurodegenerative disease. One mechanism by which HDAC inhibitors may do this is by suppressing the excessive inflammatory response of chronically activated microglia. However, the molecular mechanisms underlying this anti-inflammatory effect and the specific HDAC responsible are not fully understood. Recent data from in vivo rodent studies have shown that inhibition of class I HDACs suppresses neuroinflammation and is neuroprotective. In our study, we have identified that selective HDAC inhibition with inhibitors apicidin, MS-275 or MI-192, or specific knockdown of HDAC1 or 2 using siRNA, suppresses the expression of cytokines interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in BV-2 murine microglia activated with lipopolysaccharide (LPS). Furthermore, we found that in the absence of HDAC1, HDAC2 is up-regulated and these increased levels are compensatory, suggesting that these two HDACs have redundancy in regulating the inflammatory response of microglia. Investigating the possible underlying anti-inflammatory mechanisms suggests an increase in protein expression is not important. Taken together, this study supports the idea that inhibitors selective towards HDAC1 or HDAC2, may be therapeutically useful for targeting neuroinflammation in brain injuries and neurodegenerative disease." @default.
• W2743402721 created "2017-08-17" @default.
• W2743402721 creator A5052229728 @default.
• W2743402721 creator A5055172930 @default.
• W2743402721 creator A5074571147 @default.
• W2743402721 date "2017-10-01" @default.
• W2743402721 modified "2023-10-10" @default.
• W2743402721 title "Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism" @default.
• W2743402721 cites W136122237 @default.
• W2743402721 cites W1509256585 @default.
• W2743402721 cites W1523349613 @default.
• W2743402721 cites W1535444616 @default.
• W2743402721 cites W1583504016 @default.
• W2743402721 cites W1605373314 @default.
• W2743402721 cites W1626483287 @default.
• W2743402721 cites W1874007049 @default.
• W2743402721 cites W1960393893 @default.
• W2743402721 cites W1965942744 @default.
• W2743402721 cites W1967434207 @default.
• W2743402721 cites W1968740815 @default.
• W2743402721 cites W1975692560 @default.
• W2743402721 cites W1990677564 @default.
• W2743402721 cites W1998188269 @default.
• W2743402721 cites W1998865079 @default.
• W2743402721 cites W2002698073 @default.
• W2743402721 cites W2003460922 @default.
• W2743402721 cites W2004349171 @default.
• W2743402721 cites W2009826707 @default.
• W2743402721 cites W2011361113 @default.
• W2743402721 cites W2011718960 @default.
• W2743402721 cites W2017446437 @default.
• W2743402721 cites W2024425375 @default.
• W2743402721 cites W2036700704 @default.
• W2743402721 cites W2039098916 @default.
• W2743402721 cites W2039326711 @default.
• W2743402721 cites W2047558881 @default.
• W2743402721 cites W2050931169 @default.
• W2743402721 cites W2058345229 @default.
• W2743402721 cites W2058365710 @default.
• W2743402721 cites W2067420253 @default.
• W2743402721 cites W2071962829 @default.
• W2743402721 cites W2077762414 @default.
• W2743402721 cites W2083784041 @default.
• W2743402721 cites W2089695293 @default.
• W2743402721 cites W2092722802 @default.
• W2743402721 cites W2094034990 @default.
• W2743402721 cites W2094424802 @default.
• W2743402721 cites W2097084183 @default.
• W2743402721 cites W2101065953 @default.
• W2743402721 cites W2101924021 @default.
• W2743402721 cites W2107277218 @default.
• W2743402721 cites W2116116157 @default.
• W2743402721 cites W2143049734 @default.
• W2743402721 cites W2146398643 @default.
• W2743402721 cites W2146766478 @default.
• W2743402721 cites W2156876163 @default.
• W2743402721 cites W2162390271 @default.
• W2743402721 cites W2164594351 @default.
• W2743402721 cites W2917079005 @default.
• W2743402721 cites W333643404 @default.
• W2743402721 doi "https://doi.org/10.1111/jnc.14144" @default.
• W2743402721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28796285" @default.
• W2743402721 hasPublicationYear "2017" @default.
• W2743402721 type Work @default.
• W2743402721 sameAs 2743402721 @default.
• W2743402721 citedByCount "45" @default.
• W2743402721 countsByYear W27434027212017 @default.
• W2743402721 countsByYear W27434027212018 @default.
• W2743402721 countsByYear W27434027212019 @default.
• W2743402721 countsByYear W27434027212020 @default.
• W2743402721 countsByYear W27434027212021 @default.
• W2743402721 countsByYear W27434027212022 @default.
• W2743402721 countsByYear W27434027212023 @default.
• W2743402721 crossrefType "journal-article" @default.
• W2743402721 hasAuthorship W2743402721A5052229728 @default.
• W2743402721 hasAuthorship W2743402721A5055172930 @default.
• W2743402721 hasAuthorship W2743402721A5074571147 @default.
• W2743402721 hasBestOaLocation W27434027211 @default.
• W2743402721 hasConcept C104317684 @default.
• W2743402721 hasConcept C150903083 @default.
• W2743402721 hasConcept C164027704 @default.
• W2743402721 hasConcept C173396325 @default.
• W2743402721 hasConcept C17991360 @default.
• W2743402721 hasConcept C185592680 @default.
• W2743402721 hasConcept C190283241 @default.
• W2743402721 hasConcept C203014093 @default.
• W2743402721 hasConcept C207001950 @default.
• W2743402721 hasConcept C25498285 @default.
• W2743402721 hasConcept C2776914184 @default.
• W2743402721 hasConcept C2778305200 @default.
• W2743402721 hasConcept C2778690821 @default.
• W2743402721 hasConcept C2779830541 @default.
• W2743402721 hasConcept C502942594 @default.
• W2743402721 hasConcept C55493867 @default.
• W2743402721 hasConcept C64927066 @default.
• W2743402721 hasConcept C71723506 @default.
• W2743402721 hasConcept C85240754 @default.
• W2743402721 hasConcept C86803240 @default.

• next