Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743408113> ?p ?o ?g. }
- W2743408113 endingPage "402" @default.
- W2743408113 startingPage "392" @default.
- W2743408113 abstract "A high‑zinc (Zn) diet has been found to promote growth performance in pigs, but causes cell apoptosis in the intestinal epithelium. To investigate the mechanism underlying the high dietary Zn-induced apoptosis in porcine small intestinal epithelium, IPEC-J2 cells (intestinal porcine epithelial cells) were used to determine the effect of Zn on cell inhibitory, apoptosis, and mitochondrial membrane potential and autophagy in vitro. Results showed that Zn inhibited IPEC-J2 cell proliferation and induced apoptosis and autophagy. High concentrations of Zn induced DNA fragmentation and nuclear morphological changes, and increased intracellular Zn concentration. It also increased the protein expression level of cleaved caspase-3, caspase-8, beclin 1 and microtubule-associated protein 1 light chain 3 (LC3)-II, and the translocation of cytochrome c (Cyto C) into cytosol from mitochondria, and decreased the protein expression level of P62/SQSTM1. While 3-MA (3-methyladenine, as an autophagy inhibitor) suppressed the Zn-induced changes in the protein expression level of cleaved caspase-3 (CASP3), caspase-8 (CASP8), Cyto C, beclin 1, LC3-II and P62/SQSTM1. 3-MA decreased the Zn-induced mitochondrial apoptosis. High concentration of Zn up-regulated the relative mRNA expression level of BAX, CYCS, CASP3, CASP8, LC3-II and P62/SQSTM1 genes (p < 0.05), which were also ameliorated by 3-MA supplementation. In conclusion, autophagy inhibition significantly reduced the Zn-induced loss of mitochondrial membrane potential and attenuated the elevation of apoptosis in IPEC-J2. Autophagy and apoptosis act as partners in the Zn-induced cellular death in IPEC-J2." @default.
- W2743408113 created "2017-08-17" @default.
- W2743408113 creator A5018691719 @default.
- W2743408113 creator A5051890307 @default.
- W2743408113 creator A5067453012 @default.
- W2743408113 date "2017-10-01" @default.
- W2743408113 modified "2023-10-14" @default.
- W2743408113 title "Autophagy plays a positive role in zinc-induced apoptosis in intestinal porcine epithelial cells" @default.
- W2743408113 cites W1522261940 @default.
- W2743408113 cites W1926290119 @default.
- W2743408113 cites W1929884045 @default.
- W2743408113 cites W1969266303 @default.
- W2743408113 cites W1970487976 @default.
- W2743408113 cites W1974927871 @default.
- W2743408113 cites W1977767269 @default.
- W2743408113 cites W1992832446 @default.
- W2743408113 cites W1994823455 @default.
- W2743408113 cites W2003851398 @default.
- W2743408113 cites W2007072966 @default.
- W2743408113 cites W2014585682 @default.
- W2743408113 cites W2014918593 @default.
- W2743408113 cites W2015641421 @default.
- W2743408113 cites W2019216646 @default.
- W2743408113 cites W2027236817 @default.
- W2743408113 cites W2029685880 @default.
- W2743408113 cites W2030404074 @default.
- W2743408113 cites W2031169909 @default.
- W2743408113 cites W2034609401 @default.
- W2743408113 cites W2039842002 @default.
- W2743408113 cites W2047470637 @default.
- W2743408113 cites W2050969183 @default.
- W2743408113 cites W2056412631 @default.
- W2743408113 cites W2061288389 @default.
- W2743408113 cites W2064064392 @default.
- W2743408113 cites W2064779783 @default.
- W2743408113 cites W2073439038 @default.
- W2743408113 cites W2076281733 @default.
- W2743408113 cites W2077397852 @default.
- W2743408113 cites W2078911476 @default.
- W2743408113 cites W2105577359 @default.
- W2743408113 cites W2108800831 @default.
- W2743408113 cites W2110652761 @default.
- W2743408113 cites W2114806766 @default.
- W2743408113 cites W2118739388 @default.
- W2743408113 cites W2123671636 @default.
- W2743408113 cites W2124684134 @default.
- W2743408113 cites W2126432315 @default.
- W2743408113 cites W2126635960 @default.
- W2743408113 cites W2149611520 @default.
- W2743408113 cites W2155808288 @default.
- W2743408113 cites W2156320420 @default.
- W2743408113 cites W2163980217 @default.
- W2743408113 cites W2317926428 @default.
- W2743408113 cites W2340784210 @default.
- W2743408113 cites W2347417603 @default.
- W2743408113 doi "https://doi.org/10.1016/j.tiv.2017.08.006" @default.
- W2743408113 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28803810" @default.
- W2743408113 hasPublicationYear "2017" @default.
- W2743408113 type Work @default.
- W2743408113 sameAs 2743408113 @default.
- W2743408113 citedByCount "19" @default.
- W2743408113 countsByYear W27434081132018 @default.
- W2743408113 countsByYear W27434081132019 @default.
- W2743408113 countsByYear W27434081132020 @default.
- W2743408113 countsByYear W27434081132022 @default.
- W2743408113 countsByYear W27434081132023 @default.
- W2743408113 crossrefType "journal-article" @default.
- W2743408113 hasAuthorship W2743408113A5018691719 @default.
- W2743408113 hasAuthorship W2743408113A5051890307 @default.
- W2743408113 hasAuthorship W2743408113A5067453012 @default.
- W2743408113 hasConcept C12519072 @default.
- W2743408113 hasConcept C153911025 @default.
- W2743408113 hasConcept C185592680 @default.
- W2743408113 hasConcept C190283241 @default.
- W2743408113 hasConcept C203522944 @default.
- W2743408113 hasConcept C2781077229 @default.
- W2743408113 hasConcept C28859421 @default.
- W2743408113 hasConcept C29311851 @default.
- W2743408113 hasConcept C31573885 @default.
- W2743408113 hasConcept C43759708 @default.
- W2743408113 hasConcept C529295009 @default.
- W2743408113 hasConcept C54355233 @default.
- W2743408113 hasConcept C55493867 @default.
- W2743408113 hasConcept C79879829 @default.
- W2743408113 hasConcept C86803240 @default.
- W2743408113 hasConcept C95444343 @default.
- W2743408113 hasConceptScore W2743408113C12519072 @default.
- W2743408113 hasConceptScore W2743408113C153911025 @default.
- W2743408113 hasConceptScore W2743408113C185592680 @default.
- W2743408113 hasConceptScore W2743408113C190283241 @default.
- W2743408113 hasConceptScore W2743408113C203522944 @default.
- W2743408113 hasConceptScore W2743408113C2781077229 @default.
- W2743408113 hasConceptScore W2743408113C28859421 @default.
- W2743408113 hasConceptScore W2743408113C29311851 @default.
- W2743408113 hasConceptScore W2743408113C31573885 @default.
- W2743408113 hasConceptScore W2743408113C43759708 @default.
- W2743408113 hasConceptScore W2743408113C529295009 @default.
- W2743408113 hasConceptScore W2743408113C54355233 @default.