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- W2743531122 abstract "Surgery is the recommended treatment modality for patients with non-small cell lung cancer (NSCLC) stage I-II. Meta-analyses of randomized studies demonstrates a survival benefit with adjuvant chemotherapy—including neo-adjuvant chemotherapy—for stage IB-IIIA patients, resulting in a reduced hazard ratio (HR) to 0.83–0.92, with absolute benefits of 5.4% to 6.9% at five years. Comparable level of risk reduction has been shown with neoadjuvant chemotherapy but with less robust evidence. Currently any of the available studies that investigated the role of personalized chemotherapy based on individual gene expression have generated disappointing results. The role of targeted therapies in this setting remains undefined. A large randomized trial (ECOG 1505) demonstrated no benefit to using adjuvant bevacizumab in unselected early stage patients. Results from a large prospective placebo-controlled study showed no benefit from the use of adjuvant epidermal growth factor (EGFR) tyrosine kinase inhibitor erlotinibs (TKIs), but the study was not designed specifically for patients with tumors harboring EGFR mutations. In addition, other studies have demonstrated no effect of EGFR TKIs as adjuvant therapy in unselected patients. Ongoing large prospective studies are evaluating the role of EGFR TKIs in the EGFR-mutant population, ALK-inhibitors in the ALK+ population, and immunotherapy in the non-biomarker-selected population." @default.
- W2743531122 created "2017-08-17" @default.
- W2743531122 creator A5034509029 @default.
- W2743531122 creator A5063904421 @default.
- W2743531122 date "2018-01-01" @default.
- W2743531122 modified "2023-09-23" @default.
- W2743531122 title "Adjuvant and Neoadjuvant Chemotherapy for Early-Stage Nonsmall Cell Lung Cancer" @default.
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