FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743567609> ?p ?o ?g. }

• W2743567609 endingPage "e0182701" @default.
• W2743567609 startingPage "e0182701" @default.
• W2743567609 abstract "Dysregulated activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway by self-DNA contributes to interferonopathy and promotes autoimmune diseases. To identify potential suppressors of STING-induced type I interferon (IFN) induction, ethanol extracts of medicinal plants were screened for inhibitory activity against IFN-ß promoter activation. Notably, 70% ethanol extract of Cephalotaxus koreana specifically down-regulated STING-induced, but not TBK1- or IRF3-induced, IFN-ß promoter activity. The compounds exerting inhibitory activity specifically against STING-mediated IFN-ß promoter activation were identified as ester alkaloids isolated from the genus, Cephalotaxus, homoharringtonine and harringtonine. Furthermore, these two compounds inhibited 2’3’-cGAMP-induced IFN-stimulated gene expression and interaction between STING and TBK1. These suppressive effects were not observed with cephalotaxine devoid of the ester side-chain. Our data support the potential utility of homoharringtonine and harringtonine to treat STING-associated interferonopathy and autoimmune diseases." @default.
• W2743567609 created "2017-08-17" @default.
• W2743567609 creator A5012503420 @default.
• W2743567609 creator A5022655110 @default.
• W2743567609 creator A5054836047 @default.
• W2743567609 date "2017-08-03" @default.
• W2743567609 modified "2023-09-24" @default.
• W2743567609 title "Ester alkaloids from Cephalotaxus interfere with the 2’3’-cGAMP-induced type I interferon pathway in vitro" @default.
• W2743567609 cites W1968178474 @default.
• W2743567609 cites W1974551399 @default.
• W2743567609 cites W1976325516 @default.
• W2743567609 cites W1978210814 @default.
• W2743567609 cites W1985970596 @default.
• W2743567609 cites W1991562382 @default.
• W2743567609 cites W2004751876 @default.
• W2743567609 cites W2025268177 @default.
• W2743567609 cites W2029912515 @default.
• W2743567609 cites W2041345682 @default.
• W2743567609 cites W2042433863 @default.
• W2743567609 cites W2042755027 @default.
• W2743567609 cites W2047365750 @default.
• W2743567609 cites W2051317205 @default.
• W2743567609 cites W2055063197 @default.
• W2743567609 cites W2057539094 @default.
• W2743567609 cites W2066586758 @default.
• W2743567609 cites W2075688750 @default.
• W2743567609 cites W2095529883 @default.
• W2743567609 cites W2111969980 @default.
• W2743567609 cites W2116778443 @default.
• W2743567609 cites W2124451653 @default.
• W2743567609 cites W2127912482 @default.
• W2743567609 cites W2145568011 @default.
• W2743567609 cites W2216324555 @default.
• W2743567609 cites W2260046049 @default.
• W2743567609 cites W2288240920 @default.
• W2743567609 cites W2951137171 @default.
• W2743567609 doi "https://doi.org/10.1371/journal.pone.0182701" @default.
• W2743567609 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5542643" @default.
• W2743567609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28771599" @default.
• W2743567609 hasPublicationYear "2017" @default.
• W2743567609 type Work @default.
• W2743567609 sameAs 2743567609 @default.
• W2743567609 citedByCount "7" @default.
• W2743567609 countsByYear W27435676092020 @default.
• W2743567609 countsByYear W27435676092021 @default.
• W2743567609 countsByYear W27435676092022 @default.
• W2743567609 countsByYear W27435676092023 @default.
• W2743567609 crossrefType "journal-article" @default.
• W2743567609 hasAuthorship W2743567609A5012503420 @default.
• W2743567609 hasAuthorship W2743567609A5022655110 @default.
• W2743567609 hasAuthorship W2743567609A5054836047 @default.
• W2743567609 hasBestOaLocation W27435676091 @default.
• W2743567609 hasConcept C104317684 @default.
• W2743567609 hasConcept C127413603 @default.
• W2743567609 hasConcept C136449434 @default.
• W2743567609 hasConcept C146978453 @default.
• W2743567609 hasConcept C156155473 @default.
• W2743567609 hasConcept C170493617 @default.
• W2743567609 hasConcept C185592680 @default.
• W2743567609 hasConcept C203014093 @default.
• W2743567609 hasConcept C2776178377 @default.
• W2743567609 hasConcept C2777349159 @default.
• W2743567609 hasConcept C2778461978 @default.
• W2743567609 hasConcept C2779300339 @default.
• W2743567609 hasConcept C2780209191 @default.
• W2743567609 hasConcept C2910157418 @default.
• W2743567609 hasConcept C29537977 @default.
• W2743567609 hasConcept C55493867 @default.
• W2743567609 hasConcept C82495950 @default.
• W2743567609 hasConcept C86339819 @default.
• W2743567609 hasConcept C86803240 @default.
• W2743567609 hasConcept C98274493 @default.
• W2743567609 hasConceptScore W2743567609C104317684 @default.
• W2743567609 hasConceptScore W2743567609C127413603 @default.
• W2743567609 hasConceptScore W2743567609C136449434 @default.
• W2743567609 hasConceptScore W2743567609C146978453 @default.
• W2743567609 hasConceptScore W2743567609C156155473 @default.
• W2743567609 hasConceptScore W2743567609C170493617 @default.
• W2743567609 hasConceptScore W2743567609C185592680 @default.
• W2743567609 hasConceptScore W2743567609C203014093 @default.
• W2743567609 hasConceptScore W2743567609C2776178377 @default.
• W2743567609 hasConceptScore W2743567609C2777349159 @default.
• W2743567609 hasConceptScore W2743567609C2778461978 @default.
• W2743567609 hasConceptScore W2743567609C2779300339 @default.
• W2743567609 hasConceptScore W2743567609C2780209191 @default.
• W2743567609 hasConceptScore W2743567609C2910157418 @default.
• W2743567609 hasConceptScore W2743567609C29537977 @default.
• W2743567609 hasConceptScore W2743567609C55493867 @default.
• W2743567609 hasConceptScore W2743567609C82495950 @default.
• W2743567609 hasConceptScore W2743567609C86339819 @default.
• W2743567609 hasConceptScore W2743567609C86803240 @default.
• W2743567609 hasConceptScore W2743567609C98274493 @default.
• W2743567609 hasFunder F4320322120 @default.
• W2743567609 hasIssue "8" @default.
• W2743567609 hasLocation W27435676091 @default.
• W2743567609 hasLocation W27435676092 @default.
• W2743567609 hasLocation W27435676093 @default.
• W2743567609 hasLocation W27435676094 @default.

• next