Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743604908> ?p ?o ?g. }
- W2743604908 endingPage "2283" @default.
- W2743604908 startingPage "2277" @default.
- W2743604908 abstract "Proteinaceous nanomaterials and, in particular, virus-like particles (VLPs) have emerged as robust and uniform platforms that are seeing wider use in biomedical research. However, there are a limited number of bioconjugation reactions for functionalizing the capsids, and very few of those involve functionalization across the supramolecular quaternary structure of protein assemblies. In this work, we exploit the recently described dibromomaleimide moiety as part of a bioconjugation strategy on VLP Qβ to break and rebridge the exposed and structurally important disulfides in good yields. Not only was the stability of the quaternary structure retained after the reaction, but the newly functionalized particles also became brightly fluorescent and could be tracked in vitro using a commercially available filter set. Consequently, we show that this highly efficient bioconjugation reaction not only introduces a new functional handle between the disulfides of VLPs without compromising their thermal stability but also can be used to create a fluorescent probe." @default.
- W2743604908 created "2017-08-17" @default.
- W2743604908 creator A5009524449 @default.
- W2743604908 creator A5012922321 @default.
- W2743604908 creator A5017825677 @default.
- W2743604908 creator A5020755622 @default.
- W2743604908 creator A5024626437 @default.
- W2743604908 creator A5045936532 @default.
- W2743604908 creator A5047024251 @default.
- W2743604908 creator A5057162811 @default.
- W2743604908 creator A5068062093 @default.
- W2743604908 creator A5083031165 @default.
- W2743604908 creator A5087536328 @default.
- W2743604908 date "2017-08-22" @default.
- W2743604908 modified "2023-09-24" @default.
- W2743604908 title "Fluorescent Functionalization across Quaternary Structure in a Virus-like Particle" @default.
- W2743604908 cites W1139420436 @default.
- W2743604908 cites W1484633880 @default.
- W2743604908 cites W1488319678 @default.
- W2743604908 cites W1896441384 @default.
- W2743604908 cites W1963683058 @default.
- W2743604908 cites W1965767348 @default.
- W2743604908 cites W1967781933 @default.
- W2743604908 cites W1972333400 @default.
- W2743604908 cites W1973534955 @default.
- W2743604908 cites W1975592104 @default.
- W2743604908 cites W1976915466 @default.
- W2743604908 cites W1984111577 @default.
- W2743604908 cites W1988241746 @default.
- W2743604908 cites W1988609626 @default.
- W2743604908 cites W1994744496 @default.
- W2743604908 cites W2007307087 @default.
- W2743604908 cites W2007586902 @default.
- W2743604908 cites W2021320094 @default.
- W2743604908 cites W2021821964 @default.
- W2743604908 cites W2021878803 @default.
- W2743604908 cites W2021886965 @default.
- W2743604908 cites W2023841027 @default.
- W2743604908 cites W2025898599 @default.
- W2743604908 cites W2029007872 @default.
- W2743604908 cites W2030327971 @default.
- W2743604908 cites W2030857516 @default.
- W2743604908 cites W2043000550 @default.
- W2743604908 cites W2046303416 @default.
- W2743604908 cites W2053909954 @default.
- W2743604908 cites W2056036907 @default.
- W2743604908 cites W2059048914 @default.
- W2743604908 cites W2061020069 @default.
- W2743604908 cites W2062590613 @default.
- W2743604908 cites W2073243114 @default.
- W2743604908 cites W2079670884 @default.
- W2743604908 cites W2082065573 @default.
- W2743604908 cites W2083484480 @default.
- W2743604908 cites W2085048677 @default.
- W2743604908 cites W2098733945 @default.
- W2743604908 cites W2107898312 @default.
- W2743604908 cites W2114800918 @default.
- W2743604908 cites W2120920314 @default.
- W2743604908 cites W2121171143 @default.
- W2743604908 cites W2149913957 @default.
- W2743604908 cites W2150146274 @default.
- W2743604908 cites W2157064062 @default.
- W2743604908 cites W2190994911 @default.
- W2743604908 cites W2284921669 @default.
- W2743604908 cites W2290609019 @default.
- W2743604908 cites W2302172313 @default.
- W2743604908 cites W2327604072 @default.
- W2743604908 cites W2345836393 @default.
- W2743604908 cites W2460895663 @default.
- W2743604908 cites W2520336538 @default.
- W2743604908 cites W2534693174 @default.
- W2743604908 cites W2544822872 @default.
- W2743604908 cites W2562690513 @default.
- W2743604908 cites W2568141451 @default.
- W2743604908 cites W2585226319 @default.
- W2743604908 doi "https://doi.org/10.1021/acs.bioconjchem.7b00305" @default.
- W2743604908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787574" @default.
- W2743604908 hasPublicationYear "2017" @default.
- W2743604908 type Work @default.
- W2743604908 sameAs 2743604908 @default.
- W2743604908 citedByCount "15" @default.
- W2743604908 countsByYear W27436049082018 @default.
- W2743604908 countsByYear W27436049082019 @default.
- W2743604908 countsByYear W27436049082020 @default.
- W2743604908 countsByYear W27436049082021 @default.
- W2743604908 countsByYear W27436049082022 @default.
- W2743604908 countsByYear W27436049082023 @default.
- W2743604908 crossrefType "journal-article" @default.
- W2743604908 hasAuthorship W2743604908A5009524449 @default.
- W2743604908 hasAuthorship W2743604908A5012922321 @default.
- W2743604908 hasAuthorship W2743604908A5017825677 @default.
- W2743604908 hasAuthorship W2743604908A5020755622 @default.
- W2743604908 hasAuthorship W2743604908A5024626437 @default.
- W2743604908 hasAuthorship W2743604908A5045936532 @default.
- W2743604908 hasAuthorship W2743604908A5047024251 @default.
- W2743604908 hasAuthorship W2743604908A5057162811 @default.
- W2743604908 hasAuthorship W2743604908A5068062093 @default.
- W2743604908 hasAuthorship W2743604908A5083031165 @default.