FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743605533> ?p ?o ?g. }

• W2743605533 endingPage "522" @default.
• W2743605533 startingPage "514" @default.
• W2743605533 abstract "Cisplatin (DDP) is the most commonly used drug in testicular cancer. However, drug resistance severely limits its clinical use and the underlying mechanisms need to be further clarified. The aim of present study was to investigate the role of ATP/IP3 pathway mediated by pannexin1 (Panx-1) channels on DDP-induced apoptosis and to reveal the potential mechanisms of DDP-resistance in testicular cancer. We found that the expression of Panx-1 in I-10/DDP cells (DDP-resistance) was decreased compared with parental I-10 cells determined by western blotting and immunofluorescence assay. To further clarify the role of Panx-1 in DDP resistance, Panx-1 function was modulated by overexpression and knockdown of Panx-1 expression. Panx-1 overexpression increased DDP-induced apoptosis, ATP release and IP3 levels. On the contrary, Panx-1 silencing decreased DDP-induced apoptosis, ATP release and IP3 levels. Apyrase (hydrolyzing extracellular ATP) or xestospongin C (antagonizing IP3 receptor) also decreased DDP-induced apoptosis. Our findings demonstrate that Panx-1 is involved in DDP-resistance and ATP/IP3 pathway mediated by Panx-1 channels participates in DDP-induced apoptosis in testicular cancer. Panx-1 modulation may be interesting to amplify the clinical effect of DDP and reverse the resistance of testicular cancer cells to DDP." @default.
• W2743605533 created "2017-08-17" @default.
• W2743605533 creator A5013345797 @default.
• W2743605533 creator A5013645251 @default.
• W2743605533 creator A5015362467 @default.
• W2743605533 creator A5054309906 @default.
• W2743605533 creator A5081795294 @default.
• W2743605533 creator A5085120246 @default.
• W2743605533 creator A5086479772 @default.
• W2743605533 date "2017-10-01" @default.
• W2743605533 modified "2023-09-25" @default.
• W2743605533 title "Role of Pannexin1 channels in the resistance of I-10 testicular cancer cells to cisplatin mediated by ATP/IP3 pathway" @default.
• W2743605533 cites W1562045441 @default.
• W2743605533 cites W1888399146 @default.
• W2743605533 cites W1968410172 @default.
• W2743605533 cites W1971084572 @default.
• W2743605533 cites W1983602414 @default.
• W2743605533 cites W1985832947 @default.
• W2743605533 cites W1987604182 @default.
• W2743605533 cites W1991505853 @default.
• W2743605533 cites W1999998145 @default.
• W2743605533 cites W2016224591 @default.
• W2743605533 cites W2017612052 @default.
• W2743605533 cites W2020490204 @default.
• W2743605533 cites W2029913563 @default.
• W2743605533 cites W2035033750 @default.
• W2743605533 cites W2038218697 @default.
• W2743605533 cites W2042259903 @default.
• W2743605533 cites W2042465045 @default.
• W2743605533 cites W2050688486 @default.
• W2743605533 cites W2061390876 @default.
• W2743605533 cites W2067632426 @default.
• W2743605533 cites W2074911197 @default.
• W2743605533 cites W2078073703 @default.
• W2743605533 cites W2085004952 @default.
• W2743605533 cites W2085780740 @default.
• W2743605533 cites W2098241498 @default.
• W2743605533 cites W2108305673 @default.
• W2743605533 cites W2111278167 @default.
• W2743605533 cites W2115772750 @default.
• W2743605533 cites W2127364021 @default.
• W2743605533 cites W2138486361 @default.
• W2743605533 cites W2159590959 @default.
• W2743605533 cites W2227689269 @default.
• W2743605533 cites W2339391953 @default.
• W2743605533 cites W2394570772 @default.
• W2743605533 cites W2495977232 @default.
• W2743605533 cites W2530952888 @default.
• W2743605533 doi "https://doi.org/10.1016/j.biopha.2017.07.144" @default.
• W2743605533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28780469" @default.
• W2743605533 hasPublicationYear "2017" @default.
• W2743605533 type Work @default.
• W2743605533 sameAs 2743605533 @default.
• W2743605533 citedByCount "7" @default.
• W2743605533 countsByYear W27436055332018 @default.
• W2743605533 countsByYear W27436055332019 @default.
• W2743605533 countsByYear W27436055332021 @default.
• W2743605533 countsByYear W27436055332022 @default.
• W2743605533 countsByYear W27436055332023 @default.
• W2743605533 crossrefType "journal-article" @default.
• W2743605533 hasAuthorship W2743605533A5013345797 @default.
• W2743605533 hasAuthorship W2743605533A5013645251 @default.
• W2743605533 hasAuthorship W2743605533A5015362467 @default.
• W2743605533 hasAuthorship W2743605533A5054309906 @default.
• W2743605533 hasAuthorship W2743605533A5081795294 @default.
• W2743605533 hasAuthorship W2743605533A5085120246 @default.
• W2743605533 hasAuthorship W2743605533A5086479772 @default.
• W2743605533 hasConcept C121608353 @default.
• W2743605533 hasConcept C126322002 @default.
• W2743605533 hasConcept C173396325 @default.
• W2743605533 hasConcept C185592680 @default.
• W2743605533 hasConcept C190283241 @default.
• W2743605533 hasConcept C2776694085 @default.
• W2743605533 hasConcept C2778239845 @default.
• W2743605533 hasConcept C502942594 @default.
• W2743605533 hasConcept C55493867 @default.
• W2743605533 hasConcept C71924100 @default.
• W2743605533 hasConcept C86803240 @default.
• W2743605533 hasConcept C95444343 @default.
• W2743605533 hasConcept C96232424 @default.
• W2743605533 hasConceptScore W2743605533C121608353 @default.
• W2743605533 hasConceptScore W2743605533C126322002 @default.
• W2743605533 hasConceptScore W2743605533C173396325 @default.
• W2743605533 hasConceptScore W2743605533C185592680 @default.
• W2743605533 hasConceptScore W2743605533C190283241 @default.
• W2743605533 hasConceptScore W2743605533C2776694085 @default.
• W2743605533 hasConceptScore W2743605533C2778239845 @default.
• W2743605533 hasConceptScore W2743605533C502942594 @default.
• W2743605533 hasConceptScore W2743605533C55493867 @default.
• W2743605533 hasConceptScore W2743605533C71924100 @default.
• W2743605533 hasConceptScore W2743605533C86803240 @default.
• W2743605533 hasConceptScore W2743605533C95444343 @default.
• W2743605533 hasConceptScore W2743605533C96232424 @default.
• W2743605533 hasFunder F4320321001 @default.
• W2743605533 hasLocation W27436055331 @default.
• W2743605533 hasLocation W27436055332 @default.
• W2743605533 hasOpenAccess W2743605533 @default.
• W2743605533 hasPrimaryLocation W27436055331 @default.

• next