FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743634168> ?p ?o ?g. }

• W2743634168 endingPage "10" @default.
• W2743634168 startingPage "1" @default.
• W2743634168 abstract "Peptide-receptor imaging and therapy with radiolabeled somatostatin analogs such as 68 Ga-DOTA-TATE and 177 Lu-DOTA-TATE have become an effective treatment option for SSTR-positive neuroendocrine tumors. The purpose of this study was to evaluate the correlation of somatostatin receptor-2 (SSTR2) expression with 68 Ga-DOTA-TATE uptake and 177 Lu-DOTA-TATE therapy in neuroblastoma (NB) xenograft models. We demonstrated variable SSTR2 expression profiles in eight NB cell lines. From micro-PET imaging and autoradiography, a higher uptake of 68 Ga-DOTA-TATE was observed in SSTR2 high-expressing NB xenografts (CHLA-15) compared to SSTR2 low-expressing NB xenografts (SK-N-BE(2)). Combined autoradiography-immunohistochemistry revealed histological colocalization of SSTR2 and 68 Ga-DOTA-TATE uptake in CHLA-15 tumors. With a low dose of 177 Lu-DOTA-TATE (20 MBq/animal), tumor growth inhibition was achieved in the CHLA-15 high SSTR2 expressing xenograft model. Although, in vitro , NB cells showed variable expression levels of norepinephrine transporter (NET), a molecular target for 131 I-MIBG therapy, low 123 I-MIBG uptake was observed in all selected NB xenografts. In conclusion, SSTR2 expression levels are associated with 68 Ga-DOTA-TATE uptake and antitumor efficacy of 177 Lu-DOTA-TATE. 68 Ga-DOTA-TATE PET is superior to 123 I-MIBG SPECT imaging in detecting NB tumors in our model. Radiolabeled DOTA-TATE can be used as an agent for NB tumor imaging to potentially discriminate tumors eligible for 177 Lu-DOTA-TATE therapy." @default.
• W2743634168 created "2017-08-17" @default.
• W2743634168 creator A5012203344 @default.
• W2743634168 creator A5012704417 @default.
• W2743634168 creator A5016850642 @default.
• W2743634168 creator A5026500681 @default.
• W2743634168 creator A5032151281 @default.
• W2743634168 creator A5038794162 @default.
• W2743634168 creator A5040736751 @default.
• W2743634168 creator A5045329246 @default.
• W2743634168 creator A5046616137 @default.
• W2743634168 creator A5060910618 @default.
• W2743634168 creator A5067981226 @default.
• W2743634168 creator A5089659655 @default.
• W2743634168 creator A5090391995 @default.
• W2743634168 date "2017-01-01" @default.
• W2743634168 modified "2023-09-24" @default.
• W2743634168 title "Correlation of Somatostatin Receptor-2 Expression with Gallium-68-DOTA-TATE Uptake in Neuroblastoma Xenograft Models" @default.
• W2743634168 cites W1487709448 @default.
• W2743634168 cites W1605581961 @default.
• W2743634168 cites W1833943771 @default.
• W2743634168 cites W1978741796 @default.
• W2743634168 cites W2002695625 @default.
• W2743634168 cites W2005674134 @default.
• W2743634168 cites W2016356824 @default.
• W2743634168 cites W2049985806 @default.
• W2743634168 cites W2054620460 @default.
• W2743634168 cites W2055853082 @default.
• W2743634168 cites W2058780072 @default.
• W2743634168 cites W2064907862 @default.
• W2743634168 cites W2068875547 @default.
• W2743634168 cites W2109522938 @default.
• W2743634168 cites W2115112079 @default.
• W2743634168 cites W2125398839 @default.
• W2743634168 cites W2134257528 @default.
• W2743634168 cites W2138655697 @default.
• W2743634168 cites W2142318636 @default.
• W2743634168 cites W2144463537 @default.
• W2743634168 cites W2145680305 @default.
• W2743634168 cites W2149462465 @default.
• W2743634168 cites W2166118250 @default.
• W2743634168 cites W2256151376 @default.
• W2743634168 cites W2313490892 @default.
• W2743634168 cites W4327847560 @default.
• W2743634168 cites W65407546 @default.
• W2743634168 cites W1978592016 @default.
• W2743634168 doi "https://doi.org/10.1155/2017/9481276" @default.
• W2743634168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5612706" @default.
• W2743634168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29097943" @default.
• W2743634168 hasPublicationYear "2017" @default.
• W2743634168 type Work @default.
• W2743634168 sameAs 2743634168 @default.
• W2743634168 citedByCount "13" @default.
• W2743634168 countsByYear W27436341682018 @default.
• W2743634168 countsByYear W27436341682019 @default.
• W2743634168 countsByYear W27436341682020 @default.
• W2743634168 countsByYear W27436341682021 @default.
• W2743634168 countsByYear W27436341682022 @default.
• W2743634168 countsByYear W27436341682023 @default.
• W2743634168 crossrefType "journal-article" @default.
• W2743634168 hasAuthorship W2743634168A5012203344 @default.
• W2743634168 hasAuthorship W2743634168A5012704417 @default.
• W2743634168 hasAuthorship W2743634168A5016850642 @default.
• W2743634168 hasAuthorship W2743634168A5026500681 @default.
• W2743634168 hasAuthorship W2743634168A5032151281 @default.
• W2743634168 hasAuthorship W2743634168A5038794162 @default.
• W2743634168 hasAuthorship W2743634168A5040736751 @default.
• W2743634168 hasAuthorship W2743634168A5045329246 @default.
• W2743634168 hasAuthorship W2743634168A5046616137 @default.
• W2743634168 hasAuthorship W2743634168A5060910618 @default.
• W2743634168 hasAuthorship W2743634168A5067981226 @default.
• W2743634168 hasAuthorship W2743634168A5089659655 @default.
• W2743634168 hasAuthorship W2743634168A5090391995 @default.
• W2743634168 hasBestOaLocation W27436341681 @default.
• W2743634168 hasConcept C126322002 @default.
• W2743634168 hasConcept C150008808 @default.
• W2743634168 hasConcept C150903083 @default.
• W2743634168 hasConcept C185592680 @default.
• W2743634168 hasConcept C207001950 @default.
• W2743634168 hasConcept C2776297358 @default.
• W2743634168 hasConcept C2776715637 @default.
• W2743634168 hasConcept C2779066768 @default.
• W2743634168 hasConcept C2779931791 @default.
• W2743634168 hasConcept C2989005 @default.
• W2743634168 hasConcept C2993559085 @default.
• W2743634168 hasConcept C54355233 @default.
• W2743634168 hasConcept C71924100 @default.
• W2743634168 hasConcept C80115893 @default.
• W2743634168 hasConcept C81885089 @default.
• W2743634168 hasConcept C86803240 @default.
• W2743634168 hasConceptScore W2743634168C126322002 @default.
• W2743634168 hasConceptScore W2743634168C150008808 @default.
• W2743634168 hasConceptScore W2743634168C150903083 @default.
• W2743634168 hasConceptScore W2743634168C185592680 @default.
• W2743634168 hasConceptScore W2743634168C207001950 @default.
• W2743634168 hasConceptScore W2743634168C2776297358 @default.
• W2743634168 hasConceptScore W2743634168C2776715637 @default.
• W2743634168 hasConceptScore W2743634168C2779066768 @default.

• next