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- W2743653021 abstract "Rituximab (RTX) is a monoclonal antibody against CD20, commonly used in the treatment of hematological malignancies and autoimmune diseases. The use of RTX is related to the development of hypogammaglobulinemia and infections. Aim of this review is to summarize the evidence supporting the association of specific risk factors with the development of hypogammaglobulinemia and infections post-RTX. Immunological complications are more common in patients with malignant diseases as compared to non-malignant diseases. Moreover, the use of more than one dose of RTX, maintenance regimens, low pre-treatment basal immunoglobulin levels and the association with Mycophenolate and purine analogues represent risk factors for the development of hypogammaglobulinemia. The number of RTX courses, the evidence of low IgG levels for more than 6 months, the use of G-CSF, the occurrence of chronic lung disease, cardiac insufficiency, extra-articular involvement in patients with rheumatoid arthritis, low levels of IgG and older age have been correlated with a higher risk of infections. Even though the heterogeneity of the studies in terms of study population age and underlying disease, RTX schedules as well as differences in pre-treatment or concomitant therapy doesn't allow drawing definitive conclusions, the study of the literature highlight the association of specific risk factors with the occurrence of hypogammaglobulinemia and/or infections. A long term randomized controlled clinical trial could be useful to define a personalized evidence-based risk management plan for patients treated with RTX." @default.
- W2743653021 created "2017-08-17" @default.
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- W2743653021 date "2017-08-11" @default.
- W2743653021 modified "2023-10-17" @default.
- W2743653021 title "Risk factors predisposing to the development of hypogammaglobulinemia and infections post-Rituximab" @default.
- W2743653021 cites W1188787535 @default.
- W2743653021 cites W1485393587 @default.
- W2743653021 cites W1510382284 @default.
- W2743653021 cites W1533750434 @default.
- W2743653021 cites W1603245933 @default.
- W2743653021 cites W1870818058 @default.
- W2743653021 cites W1915689252 @default.
- W2743653021 cites W1963947949 @default.
- W2743653021 cites W1967360492 @default.
- W2743653021 cites W1969261714 @default.
- W2743653021 cites W1981933562 @default.
- W2743653021 cites W1983249596 @default.
- W2743653021 cites W2002051858 @default.
- W2743653021 cites W2011191551 @default.
- W2743653021 cites W2013176883 @default.
- W2743653021 cites W2013220008 @default.
- W2743653021 cites W2017506460 @default.
- W2743653021 cites W2022999547 @default.
- W2743653021 cites W2026711372 @default.
- W2743653021 cites W2027700596 @default.
- W2743653021 cites W2029316794 @default.
- W2743653021 cites W2038398254 @default.
- W2743653021 cites W2043799126 @default.
- W2743653021 cites W2045320931 @default.
- W2743653021 cites W2048247360 @default.
- W2743653021 cites W2049196156 @default.
- W2743653021 cites W2049461566 @default.
- W2743653021 cites W2051756219 @default.
- W2743653021 cites W2053356806 @default.
- W2743653021 cites W2053683902 @default.
- W2743653021 cites W2057262661 @default.
- W2743653021 cites W2057769184 @default.
- W2743653021 cites W2059227619 @default.
- W2743653021 cites W2059446551 @default.
- W2743653021 cites W2070412267 @default.
- W2743653021 cites W2077205545 @default.
- W2743653021 cites W2077882848 @default.
- W2743653021 cites W2079925501 @default.
- W2743653021 cites W2087949958 @default.
- W2743653021 cites W2089883615 @default.
- W2743653021 cites W2099402970 @default.
- W2743653021 cites W2100151922 @default.
- W2743653021 cites W2101778685 @default.
- W2743653021 cites W2104222372 @default.
- W2743653021 cites W2104413012 @default.
- W2743653021 cites W2106997293 @default.
- W2743653021 cites W2114302659 @default.
- W2743653021 cites W2128600935 @default.
- W2743653021 cites W2130480915 @default.
- W2743653021 cites W2131125231 @default.
- W2743653021 cites W2131621311 @default.
- W2743653021 cites W2139500303 @default.
- W2743653021 cites W2140888629 @default.
- W2743653021 cites W2141111992 @default.
- W2743653021 cites W2146687743 @default.
- W2743653021 cites W2147779566 @default.
- W2743653021 cites W2149337819 @default.
- W2743653021 cites W2155683866 @default.
- W2743653021 cites W2156324671 @default.
- W2743653021 cites W2158904722 @default.
- W2743653021 cites W2158946535 @default.
- W2743653021 cites W2166237712 @default.
- W2743653021 cites W2176269625 @default.
- W2743653021 cites W2196709345 @default.
- W2743653021 cites W2428765923 @default.
- W2743653021 cites W2483097488 @default.
- W2743653021 cites W2507690749 @default.
- W2743653021 cites W2509162812 @default.
- W2743653021 cites W2529054276 @default.
- W2743653021 cites W2537733277 @default.
- W2743653021 cites W2558904914 @default.
- W2743653021 cites W2561576516 @default.
- W2743653021 cites W752286842 @default.
- W2743653021 cites W2088574571 @default.
- W2743653021 doi "https://doi.org/10.1080/08830185.2017.1346092" @default.
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