FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743671330> ?p ?o ?g. }

• W2743671330 endingPage "2916" @default.
• W2743671330 startingPage "2911" @default.
• W2743671330 abstract "Airway remodeling is a hallmark of bronchial asthma. Our group has previously reported that the thymic stromal lymphopoietin (TSLP), an airway epithelial-derived cytokine, has a central role in the pathogenesis of airway remodeling, and that toll-like receptor (TLR) 4 signaling in epithelial cells may trigger T-helper 2 (Th2) immune responses by overexpression of TSLP. However, it is currently unclear whether TLR4 is a target in the treatment of airway remodeling in asthma. The present study established a house dust mite (HDM)-induced chronic asthmatic model in female BALB/c mice and treated the HDM-exposed mice with 3 mg/kg TAK242, as a TLR4 antagonist, 30 min prior to HDM challenge for up to 2 weeks. General structural changes in the airways were subsequently evaluated and the levels of TSLP in the bronchoalveolar lavage fluid (BALF) and interleukin (IL)-4, IL-13 and interferon (IFN)-γ in the blood serum were determined. Results indicated that TAK242 treatment markedly reduced pathological changes in the airways of HDM-induced asthmatic mice, as demonstrated by reductions in airway wall thickening, peribronchial collagen deposition and subepithelial fibrosis. Furthermore, airway hyperresponsiveness to inhaled methacholine and the levels of TSLP in the BALF and IL-4, IL-13 and IFN-γ in the peripheral blood were significantly reduced by TAK242 treatment (P<0.05). Furthermore, the shift in the IFN-γ/IL-4 ratio induced by HDM treatment was significantly reversed following TAK242 pretreatment, which indicated that TAK242 modulated Th1/Th2 immune homeostasis in the chronic asthma mouse model. The present findings in a chronic asthma mouse model suggest that TAK242 may be an efficient treatment for airway remodeling, possibly through the inhibition of TSLP overexpression and Th2 airway inflammation." @default.
• W2743671330 created "2017-08-17" @default.
• W2743671330 creator A5020670810 @default.
• W2743671330 creator A5021384155 @default.
• W2743671330 creator A5048411184 @default.
• W2743671330 creator A5049328331 @default.
• W2743671330 creator A5049793271 @default.
• W2743671330 creator A5066773836 @default.
• W2743671330 creator A5082586077 @default.
• W2743671330 creator A5082927504 @default.
• W2743671330 date "2017-08-07" @default.
• W2743671330 modified "2023-10-10" @default.
• W2743671330 title "TLR4 antagonist suppresses airway remodeling in asthma by inhibiting the T-helper 2 response" @default.
• W2743671330 cites W1791206538 @default.
• W2743671330 cites W1837564390 @default.
• W2743671330 cites W1975438745 @default.
• W2743671330 cites W2007953494 @default.
• W2743671330 cites W2011998167 @default.
• W2743671330 cites W2012950781 @default.
• W2743671330 cites W2035847981 @default.
• W2743671330 cites W2053189438 @default.
• W2743671330 cites W2054739576 @default.
• W2743671330 cites W2066523967 @default.
• W2743671330 cites W2077941293 @default.
• W2743671330 cites W2082242655 @default.
• W2743671330 cites W2083218438 @default.
• W2743671330 cites W2084074153 @default.
• W2743671330 cites W2101664092 @default.
• W2743671330 cites W2108030975 @default.
• W2743671330 cites W2112516075 @default.
• W2743671330 cites W2112898002 @default.
• W2743671330 cites W2122525426 @default.
• W2743671330 cites W2130847047 @default.
• W2743671330 cites W2142495381 @default.
• W2743671330 cites W2142899869 @default.
• W2743671330 cites W2148583736 @default.
• W2743671330 cites W2162803006 @default.
• W2743671330 cites W2165044128 @default.
• W2743671330 cites W86085617 @default.
• W2743671330 doi "https://doi.org/10.3892/etm.2017.4898" @default.
• W2743671330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5613182" @default.
• W2743671330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28966674" @default.
• W2743671330 hasPublicationYear "2017" @default.
• W2743671330 type Work @default.
• W2743671330 sameAs 2743671330 @default.
• W2743671330 citedByCount "12" @default.
• W2743671330 countsByYear W27436713302018 @default.
• W2743671330 countsByYear W27436713302019 @default.
• W2743671330 countsByYear W27436713302020 @default.
• W2743671330 countsByYear W27436713302021 @default.
• W2743671330 countsByYear W27436713302022 @default.
• W2743671330 crossrefType "journal-article" @default.
• W2743671330 hasAuthorship W2743671330A5020670810 @default.
• W2743671330 hasAuthorship W2743671330A5021384155 @default.
• W2743671330 hasAuthorship W2743671330A5048411184 @default.
• W2743671330 hasAuthorship W2743671330A5049328331 @default.
• W2743671330 hasAuthorship W2743671330A5049793271 @default.
• W2743671330 hasAuthorship W2743671330A5066773836 @default.
• W2743671330 hasAuthorship W2743671330A5082586077 @default.
• W2743671330 hasAuthorship W2743671330A5082927504 @default.
• W2743671330 hasBestOaLocation W27436713301 @default.
• W2743671330 hasConcept C126322002 @default.
• W2743671330 hasConcept C136449434 @default.
• W2743671330 hasConcept C142724271 @default.
• W2743671330 hasConcept C203014093 @default.
• W2743671330 hasConcept C207480886 @default.
• W2743671330 hasConcept C2776042228 @default.
• W2743671330 hasConcept C2776070231 @default.
• W2743671330 hasConcept C2776178081 @default.
• W2743671330 hasConcept C2776709828 @default.
• W2743671330 hasConcept C2777714996 @default.
• W2743671330 hasConcept C2777961210 @default.
• W2743671330 hasConcept C2778070265 @default.
• W2743671330 hasConcept C2778166374 @default.
• W2743671330 hasConcept C2778690821 @default.
• W2743671330 hasConcept C2779727006 @default.
• W2743671330 hasConcept C2780510475 @default.
• W2743671330 hasConcept C2780559512 @default.
• W2743671330 hasConcept C2781260171 @default.
• W2743671330 hasConcept C71924100 @default.
• W2743671330 hasConcept C74172505 @default.
• W2743671330 hasConcept C8891405 @default.
• W2743671330 hasConceptScore W2743671330C126322002 @default.
• W2743671330 hasConceptScore W2743671330C136449434 @default.
• W2743671330 hasConceptScore W2743671330C142724271 @default.
• W2743671330 hasConceptScore W2743671330C203014093 @default.
• W2743671330 hasConceptScore W2743671330C207480886 @default.
• W2743671330 hasConceptScore W2743671330C2776042228 @default.
• W2743671330 hasConceptScore W2743671330C2776070231 @default.
• W2743671330 hasConceptScore W2743671330C2776178081 @default.
• W2743671330 hasConceptScore W2743671330C2776709828 @default.
• W2743671330 hasConceptScore W2743671330C2777714996 @default.
• W2743671330 hasConceptScore W2743671330C2777961210 @default.
• W2743671330 hasConceptScore W2743671330C2778070265 @default.
• W2743671330 hasConceptScore W2743671330C2778166374 @default.
• W2743671330 hasConceptScore W2743671330C2778690821 @default.
• W2743671330 hasConceptScore W2743671330C2779727006 @default.
• W2743671330 hasConceptScore W2743671330C2780510475 @default.

• next