Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743681277> ?p ?o ?g. }
- W2743681277 endingPage "3368" @default.
- W2743681277 startingPage "3354" @default.
- W2743681277 abstract "Endoxifen, the primary active metabolite of tamoxifen, is currently being investigated as a novel endocrine therapy for the treatment of breast cancer. Tamoxifen is a selective estrogen receptor modulator that elicits potent anti-breast cancer effects. However, long-term use of tamoxifen also induces bone loss in premenopausal women and is associated with an increased risk of endometrial cancer in postmenopausal women. For these reasons, we have used a rat model system to comprehensively characterize the impact of endoxifen on the skeleton and uterus. Our results demonstrate that endoxifen elicits beneficial effects on bone in ovary-intact rats and protects against bone loss following ovariectomy. Endoxifen is also shown to reduce bone turnover in both ovary-intact and ovariectomized rats at the cellular and biochemical levels. With regard to the uterus, endoxifen decreased uterine weight but maintained luminal epithelial cell height in ovariectomized animals. Within luminal epithelial cells, endoxifen resulted in differential effects on the expression levels of estrogen receptors α and β as well as multiple other genes previously implicated in regulating epithelial cell proliferation and hypertrophy. These studies analyze the impact of extended endoxifen exposure on both bone and uterus using a Food and Drug Administration-recommended animal model. Although endoxifen is a more potent breast cancer agent than tamoxifen, the results of the present study demonstrate that endoxifen does not induce bone loss in ovary-intact rats and that it elicits partial agonistic effects on the uterus and skeleton in ovariectomized animals." @default.
- W2743681277 created "2017-08-17" @default.
- W2743681277 creator A5005528190 @default.
- W2743681277 creator A5008571716 @default.
- W2743681277 creator A5008665323 @default.
- W2743681277 creator A5027416118 @default.
- W2743681277 creator A5047808879 @default.
- W2743681277 creator A5063505576 @default.
- W2743681277 creator A5071863751 @default.
- W2743681277 creator A5082426277 @default.
- W2743681277 creator A5083904553 @default.
- W2743681277 creator A5089397647 @default.
- W2743681277 creator A5082733674 @default.
- W2743681277 date "2017-08-03" @default.
- W2743681277 modified "2023-09-23" @default.
- W2743681277 title "Skeletal and Uterotrophic Effects of Endoxifen in Female Rats" @default.
- W2743681277 cites W1865075142 @default.
- W2743681277 cites W1910142254 @default.
- W2743681277 cites W1963579050 @default.
- W2743681277 cites W1970531647 @default.
- W2743681277 cites W1971909806 @default.
- W2743681277 cites W1975973972 @default.
- W2743681277 cites W1979376598 @default.
- W2743681277 cites W1982427602 @default.
- W2743681277 cites W1986121829 @default.
- W2743681277 cites W1987126382 @default.
- W2743681277 cites W1987608812 @default.
- W2743681277 cites W1993642441 @default.
- W2743681277 cites W1994401414 @default.
- W2743681277 cites W2008984675 @default.
- W2743681277 cites W2017207536 @default.
- W2743681277 cites W2030525320 @default.
- W2743681277 cites W2031583043 @default.
- W2743681277 cites W2040818845 @default.
- W2743681277 cites W2044423309 @default.
- W2743681277 cites W2053661541 @default.
- W2743681277 cites W2055815971 @default.
- W2743681277 cites W2060092135 @default.
- W2743681277 cites W2063895733 @default.
- W2743681277 cites W2064666852 @default.
- W2743681277 cites W2065151790 @default.
- W2743681277 cites W2067184505 @default.
- W2743681277 cites W2067655878 @default.
- W2743681277 cites W2073883348 @default.
- W2743681277 cites W2078293964 @default.
- W2743681277 cites W2081333800 @default.
- W2743681277 cites W2094834328 @default.
- W2743681277 cites W2103963876 @default.
- W2743681277 cites W2104708747 @default.
- W2743681277 cites W2105382341 @default.
- W2743681277 cites W2123850291 @default.
- W2743681277 cites W2124561896 @default.
- W2743681277 cites W2125058498 @default.
- W2743681277 cites W2127677509 @default.
- W2743681277 cites W2130377362 @default.
- W2743681277 cites W2131184855 @default.
- W2743681277 cites W2131236456 @default.
- W2743681277 cites W2132660806 @default.
- W2743681277 cites W2133249365 @default.
- W2743681277 cites W2135502243 @default.
- W2743681277 cites W2136563214 @default.
- W2743681277 cites W2137411979 @default.
- W2743681277 cites W2140881331 @default.
- W2743681277 cites W2141628983 @default.
- W2743681277 cites W2143202678 @default.
- W2743681277 cites W2145440218 @default.
- W2743681277 cites W2146569020 @default.
- W2743681277 cites W2151301267 @default.
- W2743681277 cites W2154614446 @default.
- W2743681277 cites W2156155947 @default.
- W2743681277 cites W2156455256 @default.
- W2743681277 cites W2165839184 @default.
- W2743681277 cites W2171666794 @default.
- W2743681277 cites W2172189712 @default.
- W2743681277 cites W2173053672 @default.
- W2743681277 cites W2230734102 @default.
- W2743681277 cites W2407046936 @default.
- W2743681277 cites W798270409 @default.
- W2743681277 doi "https://doi.org/10.1210/en.2016-1871" @default.
- W2743681277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5659691" @default.
- W2743681277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28977607" @default.
- W2743681277 hasPublicationYear "2017" @default.
- W2743681277 type Work @default.
- W2743681277 sameAs 2743681277 @default.
- W2743681277 citedByCount "5" @default.
- W2743681277 countsByYear W27436812772019 @default.
- W2743681277 countsByYear W27436812772021 @default.
- W2743681277 countsByYear W27436812772022 @default.
- W2743681277 countsByYear W27436812772023 @default.
- W2743681277 crossrefType "journal-article" @default.
- W2743681277 hasAuthorship W2743681277A5005528190 @default.
- W2743681277 hasAuthorship W2743681277A5008571716 @default.
- W2743681277 hasAuthorship W2743681277A5008665323 @default.
- W2743681277 hasAuthorship W2743681277A5027416118 @default.
- W2743681277 hasAuthorship W2743681277A5047808879 @default.
- W2743681277 hasAuthorship W2743681277A5063505576 @default.
- W2743681277 hasAuthorship W2743681277A5071863751 @default.
- W2743681277 hasAuthorship W2743681277A5082426277 @default.