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- W2743683557 endingPage "911" @default.
- W2743683557 startingPage "893" @default.
- W2743683557 abstract "Brain iron deposits have been reported consistently in imaging and histologic examinations of patients with neurodegenerative disorders. While the origins of this finding have not been clarified yet, it is speculated that impaired iron homeostasis or deficient transport mechanisms result in the accumulation of this highly toxic metal ultimately leading to formation of reactive oxygen species and cell death. On the other hand, there are also those who support that iron is just an incidental finding, a by product of neuronal loss. A literature review has been performed in order to present the key findings in support of the iron hypothesis of neurodegeneration, as well as to identify conditions causing or resulting from iron overload and compare and contrast their features with the most prominent neurodegenerative disorders. There is an abundance of experimental and observational findings in support of the hypothesis in question; however, as neurodegeneration is a rare incident of commonly encountered iron-associated disorders of the nervous system, and this metal is found in non-neurodegenerative disorders as well, it is possible that iron is the result or even an incidental finding in neurodegeneration. Understanding the underlying processes of iron metabolism in the brain and particularly its release during cell damage is expected to provide a deeper understanding of the origins of neurodegeneration in the years to come." @default.
- W2743683557 created "2017-08-17" @default.
- W2743683557 creator A5058665706 @default.
- W2743683557 creator A5073987235 @default.
- W2743683557 date "2017-11-27" @default.
- W2743683557 modified "2023-09-27" @default.
- W2743683557 title "Iron in neurodegenerative disorders: being in the wrong place at the wrong time?" @default.
- W2743683557 cites W1514932744 @default.
- W2743683557 cites W1530657831 @default.
- W2743683557 cites W1532326447 @default.
- W2743683557 cites W1561072761 @default.
- W2743683557 cites W1578363248 @default.
- W2743683557 cites W1657532570 @default.
- W2743683557 cites W1707143272 @default.
- W2743683557 cites W1732406939 @default.
- W2743683557 cites W1846292343 @default.
- W2743683557 cites W1861611878 @default.
- W2743683557 cites W1896970469 @default.
- W2743683557 cites W1924594419 @default.
- W2743683557 cites W1937490223 @default.
- W2743683557 cites W1963698191 @default.
- W2743683557 cites W1964049915 @default.
- W2743683557 cites W1965128141 @default.
- W2743683557 cites W1966777603 @default.
- W2743683557 cites W1967922486 @default.
- W2743683557 cites W1967960746 @default.
- W2743683557 cites W1968478370 @default.
- W2743683557 cites W1969344135 @default.
- W2743683557 cites W1970716063 @default.
- W2743683557 cites W1973346209 @default.
- W2743683557 cites W1973641271 @default.
- W2743683557 cites W1974417779 @default.
- W2743683557 cites W1976970965 @default.
- W2743683557 cites W1977745350 @default.
- W2743683557 cites W1979871416 @default.
- W2743683557 cites W1980248994 @default.
- W2743683557 cites W1980888855 @default.
- W2743683557 cites W1981835221 @default.
- W2743683557 cites W1982643425 @default.
- W2743683557 cites W1982855701 @default.
- W2743683557 cites W1983995854 @default.
- W2743683557 cites W1985028019 @default.
- W2743683557 cites W1988540874 @default.
- W2743683557 cites W1990763168 @default.
- W2743683557 cites W1991976348 @default.
- W2743683557 cites W1994934436 @default.
- W2743683557 cites W1996175319 @default.
- W2743683557 cites W1996579240 @default.
- W2743683557 cites W1997295728 @default.
- W2743683557 cites W1998092655 @default.
- W2743683557 cites W1998115145 @default.
- W2743683557 cites W2001854547 @default.
- W2743683557 cites W2002559713 @default.
- W2743683557 cites W200458083 @default.
- W2743683557 cites W2004922023 @default.
- W2743683557 cites W2006517335 @default.
- W2743683557 cites W2007208756 @default.
- W2743683557 cites W2007740516 @default.
- W2743683557 cites W2008788704 @default.
- W2743683557 cites W2011538447 @default.
- W2743683557 cites W2014256366 @default.
- W2743683557 cites W2014627437 @default.
- W2743683557 cites W2017159332 @default.
- W2743683557 cites W2020802723 @default.
- W2743683557 cites W2021602255 @default.
- W2743683557 cites W2022445394 @default.
- W2743683557 cites W2029443758 @default.
- W2743683557 cites W2029554736 @default.
- W2743683557 cites W2029644308 @default.
- W2743683557 cites W2032870207 @default.
- W2743683557 cites W2033016232 @default.
- W2743683557 cites W2033914575 @default.
- W2743683557 cites W2036139685 @default.
- W2743683557 cites W2036740787 @default.
- W2743683557 cites W2037981237 @default.
- W2743683557 cites W2038003980 @default.
- W2743683557 cites W2040584350 @default.
- W2743683557 cites W2040987676 @default.
- W2743683557 cites W2041327900 @default.
- W2743683557 cites W2042216669 @default.
- W2743683557 cites W2045465366 @default.
- W2743683557 cites W2048886113 @default.
- W2743683557 cites W2049366603 @default.
- W2743683557 cites W2049888915 @default.
- W2743683557 cites W2050054177 @default.
- W2743683557 cites W2051061512 @default.
- W2743683557 cites W2052131645 @default.
- W2743683557 cites W2052742260 @default.
- W2743683557 cites W2053116497 @default.
- W2743683557 cites W2054326641 @default.
- W2743683557 cites W2054348646 @default.
- W2743683557 cites W2054702846 @default.
- W2743683557 cites W2056360572 @default.
- W2743683557 cites W2057042201 @default.
- W2743683557 cites W2058539691 @default.
- W2743683557 cites W2061600722 @default.
- W2743683557 cites W2062065994 @default.
- W2743683557 cites W2062073205 @default.