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• W2743686539 endingPage "e0182648" @default.
• W2743686539 startingPage "e0182648" @default.
• W2743686539 abstract "Hippocampal theta oscillations (4-12 Hz) are consistently recorded during memory tasks and spatial navigation. Despite several known circuits and structures that generate hippocampal theta locally in vitro, none of them were found to be critical in vivo, and the hippocampal theta rhythm is severely attenuated by disruption of external input from medial septum or entorhinal cortex. We investigated these discrepancies that question the sufficiency and robustness of hippocampal theta generation using a biophysical spiking network model of the CA3 region of the hippocampus that included an interconnected network of pyramidal cells, inhibitory basket cells (BC) and oriens-lacunosum moleculare (OLM) cells. The model was developed by matching biological data characterizing neuronal firing patterns, synaptic dynamics, short-term synaptic plasticity, neuromodulatory inputs, and the three-dimensional organization of the hippocampus. The model generated theta power robustly through five cooperating generators: spiking oscillations of pyramidal cells, recurrent connections between them, slow-firing interneurons and pyramidal cells subnetwork, the fast-spiking interneurons and pyramidal cells subnetwork, and non-rhythmic structured external input from entorhinal cortex to CA3. We used the modeling framework to quantify the relative contributions of each of these generators to theta power, across different cholinergic states. The largest contribution to theta power was that of the divergent input from the entorhinal cortex to CA3, despite being constrained to random Poisson activity. We found that the low cholinergic states engaged the recurrent connections in generating theta activity, whereas high cholinergic states utilized the OLM-pyramidal subnetwork. These findings revealed that theta might be generated differently across cholinergic states, and demonstrated a direct link between specific theta generators and neuromodulatory states." @default.
• W2743686539 created "2017-08-17" @default.
• W2743686539 creator A5027980873 @default.
• W2743686539 creator A5036797460 @default.
• W2743686539 date "2017-08-07" @default.
• W2743686539 modified "2023-10-17" @default.
• W2743686539 title "An integrative model of the intrinsic hippocampal theta rhythm" @default.
• W2743686539 cites W103838389 @default.
• W2743686539 cites W1482435409 @default.
• W2743686539 cites W1501360999 @default.
• W2743686539 cites W1505034902 @default.
• W2743686539 cites W1525542820 @default.
• W2743686539 cites W1536871616 @default.
• W2743686539 cites W1543149166 @default.
• W2743686539 cites W1568625389 @default.
• W2743686539 cites W1581532160 @default.
• W2743686539 cites W1630155501 @default.
• W2743686539 cites W1857554509 @default.
• W2743686539 cites W1888008771 @default.
• W2743686539 cites W1944155217 @default.
• W2743686539 cites W1961476520 @default.
• W2743686539 cites W1963920688 @default.
• W2743686539 cites W1965911542 @default.
• W2743686539 cites W1967515954 @default.
• W2743686539 cites W1973372728 @default.
• W2743686539 cites W1973703467 @default.
• W2743686539 cites W1976730582 @default.
• W2743686539 cites W1978820760 @default.
• W2743686539 cites W1980721898 @default.
• W2743686539 cites W1982713952 @default.
• W2743686539 cites W1983066713 @default.
• W2743686539 cites W1983628429 @default.
• W2743686539 cites W1985600786 @default.
• W2743686539 cites W1992388076 @default.
• W2743686539 cites W1993153103 @default.
• W2743686539 cites W1994839334 @default.
• W2743686539 cites W2010928535 @default.
• W2743686539 cites W2011459128 @default.
• W2743686539 cites W2013427111 @default.
• W2743686539 cites W2018129607 @default.
• W2743686539 cites W2018189834 @default.
• W2743686539 cites W2019054821 @default.
• W2743686539 cites W2022864922 @default.
• W2743686539 cites W2025457757 @default.
• W2743686539 cites W2025559018 @default.
• W2743686539 cites W2026199143 @default.
• W2743686539 cites W2030033817 @default.
• W2743686539 cites W2035248798 @default.
• W2743686539 cites W2045611434 @default.
• W2743686539 cites W2045621697 @default.
• W2743686539 cites W2046198005 @default.
• W2743686539 cites W2047418886 @default.
• W2743686539 cites W2048528277 @default.
• W2743686539 cites W2054914622 @default.
• W2743686539 cites W2054994025 @default.
• W2743686539 cites W2056336718 @default.
• W2743686539 cites W2058022492 @default.
• W2743686539 cites W2058298658 @default.
• W2743686539 cites W2058464828 @default.
• W2743686539 cites W2060198709 @default.
• W2743686539 cites W2061960110 @default.
• W2743686539 cites W2062060507 @default.
• W2743686539 cites W2066420165 @default.
• W2743686539 cites W2066464582 @default.
• W2743686539 cites W2071213436 @default.
• W2743686539 cites W2073366868 @default.
• W2743686539 cites W2073543201 @default.
• W2743686539 cites W2076664481 @default.
• W2743686539 cites W2080041388 @default.
• W2743686539 cites W2080961971 @default.
• W2743686539 cites W2081574780 @default.
• W2743686539 cites W2083547018 @default.
• W2743686539 cites W2085417748 @default.
• W2743686539 cites W2086120961 @default.
• W2743686539 cites W2088358935 @default.
• W2743686539 cites W2092017451 @default.
• W2743686539 cites W2098186057 @default.
• W2743686539 cites W2100273034 @default.
• W2743686539 cites W2101954189 @default.
• W2743686539 cites W2102698571 @default.
• W2743686539 cites W2110802967 @default.
• W2743686539 cites W2111260543 @default.
• W2743686539 cites W2111370876 @default.
• W2743686539 cites W2114000527 @default.
• W2743686539 cites W2117010174 @default.
• W2743686539 cites W2117583411 @default.
• W2743686539 cites W2121330924 @default.
• W2743686539 cites W2122463514 @default.
• W2743686539 cites W2122492788 @default.
• W2743686539 cites W2122865736 @default.
• W2743686539 cites W2124793944 @default.
• W2743686539 cites W2125706064 @default.
• W2743686539 cites W2126385250 @default.
• W2743686539 cites W2126561217 @default.
• W2743686539 cites W2126879375 @default.
• W2743686539 cites W2131255734 @default.
• W2743686539 cites W2134072465 @default.
• W2743686539 cites W2134610645 @default.

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