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• W2743726780 abstract "A constriction in the neural tube at the junction of the midbrain and hindbrain is a conserved feature of vertebrate embryos. The constriction is a defining feature of the midbrain-hindbrain boundary (MHB), a signaling center that patterns the adjacent midbrain and rostral hindbrain and forms at the junction of two gene expression domains in the early neural plate: an anterior otx2/wnt1 positive domain and a posterior gbx/fgf8 positive domain. otx2 and gbx genes encode mutually repressive transcription factors that create a lineage restriction boundary at their expression interface. Wnt and Fgf genes form a mutually dependent feedback system that maintains their expression domains on the otx2 or gbx side of the boundary, respectively. Constriction morphogenesis occurs after these conserved gene expression domains are established and while their mutual interactions maintain their expression pattern; consequently, mutant studies in zebrafish have led to the suggestion that constriction morphogenesis should be considered a unique phase of MHB development. We analyzed MHB morphogenesis in fgf8 loss of function zebrafish embryos using a reporter driven by the conserved wnt1 enhancer to visualize anterior boundary cells. We found that fgf8 loss of function results in a re-activation of wnt1 reporter expression posterior to the boundary simultaneous with an inactivation of the wnt1 reporter in the anterior boundary cells, and that these events correlate with relaxation of the boundary constriction. In consideration of other results that correlate the boundary constriction with Wnt and Fgf expression, we propose that the maintenance of an active Wnt-Fgf feedback loop is a key factor in driving the morphogenesis of the MHB constriction." @default.
• W2743726780 created "2017-08-17" @default.
• W2743726780 creator A5012492749 @default.
• W2743726780 creator A5016949011 @default.
• W2743726780 creator A5019444941 @default.
• W2743726780 creator A5061603084 @default.
• W2743726780 creator A5062500025 @default.
• W2743726780 date "2017-08-03" @default.
• W2743726780 modified "2023-10-15" @default.
• W2743726780 title "Midbrain-Hindbrain Boundary Morphogenesis: At the Intersection of Wnt and Fgf Signaling" @default.
• W2743726780 cites W1524992328 @default.
• W2743726780 cites W1603850560 @default.
• W2743726780 cites W1638088518 @default.
• W2743726780 cites W1961042026 @default.
• W2743726780 cites W1965647283 @default.
• W2743726780 cites W1967803088 @default.
• W2743726780 cites W1970480709 @default.
• W2743726780 cites W1974712344 @default.
• W2743726780 cites W1977300801 @default.
• W2743726780 cites W1977786555 @default.
• W2743726780 cites W1978266492 @default.
• W2743726780 cites W1980632075 @default.
• W2743726780 cites W1981747964 @default.
• W2743726780 cites W1982433848 @default.
• W2743726780 cites W1984048199 @default.
• W2743726780 cites W1985127608 @default.
• W2743726780 cites W1986757314 @default.
• W2743726780 cites W1986771585 @default.
• W2743726780 cites W1988546517 @default.
• W2743726780 cites W1989194294 @default.
• W2743726780 cites W1990447302 @default.
• W2743726780 cites W1992581315 @default.
• W2743726780 cites W1993101912 @default.
• W2743726780 cites W1996885705 @default.
• W2743726780 cites W1998022494 @default.
• W2743726780 cites W1999155535 @default.
• W2743726780 cites W2002306043 @default.
• W2743726780 cites W2002378277 @default.
• W2743726780 cites W2002912842 @default.
• W2743726780 cites W2004201400 @default.
• W2743726780 cites W2005078880 @default.
• W2743726780 cites W2005345343 @default.
• W2743726780 cites W2011839406 @default.
• W2743726780 cites W2016871070 @default.
• W2743726780 cites W2017471776 @default.
• W2743726780 cites W2019463878 @default.
• W2743726780 cites W2025506744 @default.
• W2743726780 cites W2026989479 @default.
• W2743726780 cites W2027478164 @default.
• W2743726780 cites W2028415754 @default.
• W2743726780 cites W2028543544 @default.
• W2743726780 cites W2030224529 @default.
• W2743726780 cites W2031312855 @default.
• W2743726780 cites W2033291406 @default.
• W2743726780 cites W2033543895 @default.
• W2743726780 cites W2034972941 @default.
• W2743726780 cites W2037947871 @default.
• W2743726780 cites W2039705224 @default.
• W2743726780 cites W2041884290 @default.
• W2743726780 cites W2042545863 @default.
• W2743726780 cites W2045464049 @default.
• W2743726780 cites W2046813157 @default.
• W2743726780 cites W2050032205 @default.
• W2743726780 cites W2050721997 @default.
• W2743726780 cites W2050955881 @default.
• W2743726780 cites W2052186115 @default.
• W2743726780 cites W2052845516 @default.
• W2743726780 cites W2053270078 @default.
• W2743726780 cites W2057400853 @default.
• W2743726780 cites W2057725643 @default.
• W2743726780 cites W2058176797 @default.
• W2743726780 cites W2060643961 @default.
• W2743726780 cites W2060740193 @default.
• W2743726780 cites W2060761159 @default.
• W2743726780 cites W2061517864 @default.
• W2743726780 cites W2065045053 @default.
• W2743726780 cites W2068003838 @default.
• W2743726780 cites W2071583976 @default.
• W2743726780 cites W2073497154 @default.
• W2743726780 cites W2076218857 @default.
• W2743726780 cites W2076420955 @default.
• W2743726780 cites W2084590439 @default.
• W2743726780 cites W2085346096 @default.
• W2743726780 cites W2085912440 @default.
• W2743726780 cites W2086245382 @default.
• W2743726780 cites W2089028610 @default.
• W2743726780 cites W2090440175 @default.
• W2743726780 cites W2091003871 @default.
• W2743726780 cites W2094740113 @default.
• W2743726780 cites W2095202492 @default.
• W2743726780 cites W2095877450 @default.
• W2743726780 cites W2097556271 @default.
• W2743726780 cites W2097946485 @default.
• W2743726780 cites W2102735467 @default.
• W2743726780 cites W2103035251 @default.
• W2743726780 cites W2105123098 @default.
• W2743726780 cites W2108489942 @default.
• W2743726780 cites W2108652951 @default.
• W2743726780 cites W2117782354 @default.
• W2743726780 cites W2119776620 @default.

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