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- W2743744603 abstract "Determining the functional relationship between Tau phosphorylation and aggregation has proven a challenge owing to the multiple potential phosphorylation sites and their clustering in the Tau sequence. We use here in vitro kinase assays combined with NMR spectroscopy as an analytical tool to generate well-characterized phosphorylated Tau samples and show that the combined phosphorylation at the Ser202/Thr205/Ser208 sites, together with absence of phosphorylation at the Ser262 site, yields a Tau sample that readily forms fibers, as observed by thioflavin T fluorescence and electron microscopy. On the basis of conformational analysis of synthetic phosphorylated peptides, we show that aggregation of the samples correlates with destabilization of the turn-like structure defined by phosphorylation of Ser202/Thr205." @default.
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- W2743744603 date "2017-08-07" @default.
- W2743744603 modified "2023-10-18" @default.
- W2743744603 title "Identification of the Tau phosphorylation pattern that drives its aggregation" @default.
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- W2743744603 doi "https://doi.org/10.1073/pnas.1708448114" @default.
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