Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743762009> ?p ?o ?g. }
- W2743762009 endingPage "555" @default.
- W2743762009 startingPage "551" @default.
- W2743762009 abstract "Purpose of review Several new therapeutic modalities have recently become available to be used in patients with cystic fibrosis such as potentiators, modulators, and probiotics. Although the effects on pulmonary function have been well documented, gastrointestinal outcomes have been addressed only rarely. Recent findings Both the potentiator (ivacaftor) and the potentiator/modulator combination (ivacaftor/lumacaftor) that are currently on the market have a positive effect on BMI. Young patients (2–5 years of age) with a gating mutation may show improvement of exocrine pancreatic function on ivacaftor. In this specific patient population this agent also seems to improve intestinal pH and reflux. The effect of these medications on other gastrointestinal outcomes, such as intestinal inflammation and cystic fibrosis liver disease, has not been described so far. Furthermore, the results of several trials suggest that probiotics might reduce intestinal inflammation. Finally, organoids might be used to predict in vitro the clinical effect of potentiators and modulators. Summary The effect of new interventions on the gastrointestinal outcomes studied so far is favourable. Future studies should address the effect on other gastrointestinal parameters." @default.
- W2743762009 created "2017-08-17" @default.
- W2743762009 creator A5034630836 @default.
- W2743762009 creator A5053769006 @default.
- W2743762009 creator A5058559696 @default.
- W2743762009 creator A5072506675 @default.
- W2743762009 date "2017-11-01" @default.
- W2743762009 modified "2023-09-26" @default.
- W2743762009 title "Effects of new and emerging therapies on gastrointestinal outcomes in cystic fibrosis" @default.
- W2743762009 cites W1527111258 @default.
- W2743762009 cites W1589654967 @default.
- W2743762009 cites W1780057455 @default.
- W2743762009 cites W1846339574 @default.
- W2743762009 cites W1986316308 @default.
- W2743762009 cites W1993611202 @default.
- W2743762009 cites W1998349425 @default.
- W2743762009 cites W2001334607 @default.
- W2743762009 cites W2004835498 @default.
- W2743762009 cites W2007935931 @default.
- W2743762009 cites W2015289081 @default.
- W2743762009 cites W2016073847 @default.
- W2743762009 cites W2023846202 @default.
- W2743762009 cites W2039599894 @default.
- W2743762009 cites W2061395450 @default.
- W2743762009 cites W2083953573 @default.
- W2743762009 cites W2086631280 @default.
- W2743762009 cites W2087127819 @default.
- W2743762009 cites W2095687634 @default.
- W2743762009 cites W2111514772 @default.
- W2743762009 cites W2111857260 @default.
- W2743762009 cites W2116071769 @default.
- W2743762009 cites W2120478186 @default.
- W2743762009 cites W2140024481 @default.
- W2743762009 cites W2140868856 @default.
- W2743762009 cites W2142231009 @default.
- W2743762009 cites W2149161940 @default.
- W2743762009 cites W2150113459 @default.
- W2743762009 cites W2151829259 @default.
- W2743762009 cites W2254054106 @default.
- W2743762009 cites W2287258646 @default.
- W2743762009 cites W2288547206 @default.
- W2743762009 cites W2462428454 @default.
- W2743762009 cites W2465114161 @default.
- W2743762009 cites W2492825192 @default.
- W2743762009 cites W2513188782 @default.
- W2743762009 cites W2525174577 @default.
- W2743762009 cites W2545892265 @default.
- W2743762009 cites W2547947198 @default.
- W2743762009 cites W2564673452 @default.
- W2743762009 cites W2595297484 @default.
- W2743762009 cites W2613079570 @default.
- W2743762009 cites W2624387478 @default.
- W2743762009 doi "https://doi.org/10.1097/mcp.0000000000000423" @default.
- W2743762009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787381" @default.
- W2743762009 hasPublicationYear "2017" @default.
- W2743762009 type Work @default.
- W2743762009 sameAs 2743762009 @default.
- W2743762009 citedByCount "11" @default.
- W2743762009 countsByYear W27437620092018 @default.
- W2743762009 countsByYear W27437620092019 @default.
- W2743762009 countsByYear W27437620092020 @default.
- W2743762009 countsByYear W27437620092022 @default.
- W2743762009 countsByYear W27437620092023 @default.
- W2743762009 crossrefType "journal-article" @default.
- W2743762009 hasAuthorship W2743762009A5034630836 @default.
- W2743762009 hasAuthorship W2743762009A5053769006 @default.
- W2743762009 hasAuthorship W2743762009A5058559696 @default.
- W2743762009 hasAuthorship W2743762009A5072506675 @default.
- W2743762009 hasConcept C126322002 @default.
- W2743762009 hasConcept C164718446 @default.
- W2743762009 hasConcept C177713679 @default.
- W2743762009 hasConcept C203014093 @default.
- W2743762009 hasConcept C2776502428 @default.
- W2743762009 hasConcept C2776938444 @default.
- W2743762009 hasConcept C2778099472 @default.
- W2743762009 hasConcept C2778428886 @default.
- W2743762009 hasConcept C2779134260 @default.
- W2743762009 hasConcept C2908647359 @default.
- W2743762009 hasConcept C71924100 @default.
- W2743762009 hasConcept C90924648 @default.
- W2743762009 hasConcept C99454951 @default.
- W2743762009 hasConceptScore W2743762009C126322002 @default.
- W2743762009 hasConceptScore W2743762009C164718446 @default.
- W2743762009 hasConceptScore W2743762009C177713679 @default.
- W2743762009 hasConceptScore W2743762009C203014093 @default.
- W2743762009 hasConceptScore W2743762009C2776502428 @default.
- W2743762009 hasConceptScore W2743762009C2776938444 @default.
- W2743762009 hasConceptScore W2743762009C2778099472 @default.
- W2743762009 hasConceptScore W2743762009C2778428886 @default.
- W2743762009 hasConceptScore W2743762009C2779134260 @default.
- W2743762009 hasConceptScore W2743762009C2908647359 @default.
- W2743762009 hasConceptScore W2743762009C71924100 @default.
- W2743762009 hasConceptScore W2743762009C90924648 @default.
- W2743762009 hasConceptScore W2743762009C99454951 @default.
- W2743762009 hasIssue "6" @default.
- W2743762009 hasLocation W27437620091 @default.
- W2743762009 hasLocation W27437620092 @default.
- W2743762009 hasOpenAccess W2743762009 @default.