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• W2743803747 endingPage "L1068" @default.
• W2743803747 startingPage "L1058" @default.
• W2743803747 abstract "A mucosal oxidative burst is a hallmark response to pollen exposure that promotes allergic inflammatory responses. Reactive species constituents of oxidative stress signal via the modification of cellular molecules including nucleic acids. One of the most abundant forms of oxidative genomic base damage is 8-oxo-7,8-dihydroguanine (8-oxoG), which is removed from DNA by 8-oxoguanine DNA glycosylase 1 (OGG1). OGG1 in complex with 8-oxoG acts as a GDP-GTP exchange factor and induces acute inflammation; however, the mechanism(s) by which OGG1 signaling regulates allergic airway inflammation is not known. Here, we postulate that the OGG1 signaling pathway differentially altered the levels of small regulatory RNAs and increased the expression of T helper 2 (Th2) cytokines in ragweed pollen extract (RWPE)-challenged lungs. To determine this, the lungs of sensitized mice expressing or lacking OGG1 were challenged with RWPE and/or with OGG1's excision product 8-oxoG. The responses in lungs were assessed by next-generation sequencing, as well as various molecular and histological approaches. The results showed that RWPE challenge induced oxidative burst and damage to DNA and activated OGG1 signaling, resulting in the differential expression of 84 micro-RNAs (miRNAs), which then exacerbated antigen-driven allergic inflammation and histological changes in the lungs. The exogenous administration of the downregulated let-7b-p3 mimetic or inhibitors of upregulated miR-23a or miR-27a decreased eosinophil recruitment and mucus and collagen production via controlling the expression of IL-4, IL-5, and IL-13. Together, these data demonstrate the roles of OGG1 signaling in the regulation of antigen-driven allergic immune responses via differential expression of miRNAs upstream of Th2 cytokines and eosinophils." @default.
• W2743803747 created "2017-08-17" @default.
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• W2743803747 date "2017-12-01" @default.
• W2743803747 modified "2023-10-16" @default.
• W2743803747 title "Pollen-induced oxidative DNA damage response regulates miRNAs controlling allergic inflammation" @default.
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• W2743803747 cites W1983794260 @default.
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• W2743803747 cites W2002220658 @default.
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• W2743803747 cites W2007031153 @default.
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• W2743803747 cites W2012040132 @default.
• W2743803747 cites W2012952121 @default.
• W2743803747 cites W2015726973 @default.
• W2743803747 cites W2029243559 @default.
• W2743803747 cites W2031842372 @default.
• W2743803747 cites W2032463467 @default.
• W2743803747 cites W2036075099 @default.
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• W2743803747 cites W2058856567 @default.
• W2743803747 cites W2059357290 @default.
• W2743803747 cites W2064538313 @default.
• W2743803747 cites W2073791969 @default.
• W2743803747 cites W2075860675 @default.
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• W2743803747 cites W2076263274 @default.
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• W2743803747 doi "https://doi.org/10.1152/ajplung.00141.2017" @default.
• W2743803747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5814700" @default.
• W2743803747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28798252" @default.
• W2743803747 hasPublicationYear "2017" @default.
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