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• W2743863188 endingPage "e0182187" @default.
• W2743863188 startingPage "e0182187" @default.
• W2743863188 abstract "Erythrocyte-binding antigens (EBAs) and P. falciparum reticulocyte-binding homologue proteins (PfRhs) are two important protein families that can vary in expression and utilization by P. falciparum to evade inhibitory antibodies. We evaluated antibodies at repeated time-points among individuals living in an endemic region in Nigeria over almost one year against these vaccine candidates. Antibody levels against EBA140, EBA175, EBA181, PfRh2, PfRh4, and MSP2, were measured by ELISA. We also used parasites with disrupted EBA140, EBA175 and EBA181 genes to show that all these were targets of invasion inhibitory antibodies. However, antigenic targets of inhibitory antibodies were not stable and changed substantially over time in most individuals, independent of age. Antibodies levels measured by ELISA also varied within and between individuals over time and the antibodies against EBA181, PfRh2 and MSP2 declined more rapidly in younger individuals (≤15 years) compared with older (>15). The breadth of high antibody responses over time was more influenced by age than by the frequency of infection. High antibody levels were associated with a more stable invasion inhibitory response, which could indicate that during the long process of formation of immunity, many changes not only in levels but also in functional responses are needed. This is an important finding in understanding natural immunity against malaria, which is essential for making an efficacious vaccine." @default.
• W2743863188 created "2017-08-17" @default.
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• W2743863188 date "2017-08-07" @default.
• W2743863188 modified "2023-10-16" @default.
• W2743863188 title "Acquisition, maintenance and adaptation of invasion inhibitory antibodies against Plasmodium falciparum invasion ligands involved in immune evasion" @default.
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• W2743863188 doi "https://doi.org/10.1371/journal.pone.0182187" @default.
• W2743863188 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5546579" @default.
• W2743863188 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28787025" @default.
• W2743863188 hasPublicationYear "2017" @default.
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