FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743919250> ?p ?o ?g. }

• W2743919250 endingPage "2901" @default.
• W2743919250 startingPage "2891" @default.
• W2743919250 abstract "There is a pressing need for biomarkers that can distinguish indolent from aggressive prostate cancer to prevent over-treatment of patients with indolent tumor. Golgi targeting of glycosyltransferases was characterized by confocal microscopy after knockdown of GM130, giantin, or both. N-glycans on a trans-Golgi enzyme β4galactosyltransferase-1 isolated by immunoprecipitation from androgen-sensitive and independent prostate cancer cells were determined by matrix-assisted laser desorption-time of flight-mass spectrometry. In situ proximity ligation assay was employed to determine co-localization of (a) α-mannosidase IA, an enzyme required for processing Man8GlcNAc2 down to Man5GlcNAc2 to enable synthesis of complex-type N-glycans, with giantin, GM130, and GRASP65, and (b) trans-Golgi glycosyltransferases with high mannose N-glycans terminated with α3-mannose. Defective giantin in androgen-independent prostate cancer cells results in a shift of Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65. Consequently, trans-Golgi enzymes and cell surface glycoproteins acquire high mannose N-glycans, which are absent in cells with functional giantin. In situ proximity ligation assays of co-localization of α-mannosidase IA with GM130 and GRASP65, and trans-Golgi glycosyltransferases with high mannose N-glycans are negative in androgen-sensitive LNCaP C-33 cells but positive in androgen-independent LNCaP C-81 and DU145 cells, and LNCaP C-33 cells devoid of giantin. In situ proximity ligation assays of Golgi localization of α-mannosidase IA at giantin versus GM130-GRASP65 site, and absence or presence of N-glycans terminated with α3-mannose on trans-Golgi glycosyltransferases may be useful for distinguishing indolent from aggressive prostate cancer cells." @default.
• W2743919250 created "2017-08-17" @default.
• W2743919250 creator A5026534555 @default.
• W2743919250 creator A5061709478 @default.
• W2743919250 creator A5062117439 @default.
• W2743919250 creator A5063759410 @default.
• W2743919250 date "2017-11-01" @default.
• W2743919250 modified "2023-10-18" @default.
• W2743919250 title "Shifted Golgi targeting of glycosyltransferases and α-mannosidase IA from giantin to GM130-GRASP65 results in formation of high mannose N -glycans in aggressive prostate cancer cells" @default.
• W2743919250 cites W1182461782 @default.
• W2743919250 cites W1504213150 @default.
• W2743919250 cites W1544375765 @default.
• W2743919250 cites W1622325070 @default.
• W2743919250 cites W1875490279 @default.
• W2743919250 cites W1967907911 @default.
• W2743919250 cites W1991366673 @default.
• W2743919250 cites W1998718563 @default.
• W2743919250 cites W2009666895 @default.
• W2743919250 cites W2019577213 @default.
• W2743919250 cites W2025590149 @default.
• W2743919250 cites W2045336306 @default.
• W2743919250 cites W2049247159 @default.
• W2743919250 cites W2062440930 @default.
• W2743919250 cites W2063592545 @default.
• W2743919250 cites W2067061290 @default.
• W2743919250 cites W2070561133 @default.
• W2743919250 cites W2083344986 @default.
• W2743919250 cites W2085378807 @default.
• W2743919250 cites W2090552917 @default.
• W2743919250 cites W2091956705 @default.
• W2743919250 cites W2095224133 @default.
• W2743919250 cites W2096128160 @default.
• W2743919250 cites W2100496055 @default.
• W2743919250 cites W2115710616 @default.
• W2743919250 cites W2122990248 @default.
• W2743919250 cites W2128204487 @default.
• W2743919250 cites W2134294354 @default.
• W2743919250 cites W2139368593 @default.
• W2743919250 cites W2140016888 @default.
• W2743919250 cites W2150675831 @default.
• W2743919250 cites W2153209603 @default.
• W2743919250 cites W2158008391 @default.
• W2743919250 cites W2168355000 @default.
• W2743919250 cites W2169987970 @default.
• W2743919250 cites W2186050003 @default.
• W2743919250 cites W2235523093 @default.
• W2743919250 cites W2435326962 @default.
• W2743919250 cites W4245814297 @default.
• W2743919250 doi "https://doi.org/10.1016/j.bbagen.2017.08.006" @default.
• W2743919250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28782625" @default.
• W2743919250 hasPublicationYear "2017" @default.
• W2743919250 type Work @default.
• W2743919250 sameAs 2743919250 @default.
• W2743919250 citedByCount "18" @default.
• W2743919250 countsByYear W27439192502018 @default.
• W2743919250 countsByYear W27439192502019 @default.
• W2743919250 countsByYear W27439192502020 @default.
• W2743919250 countsByYear W27439192502021 @default.
• W2743919250 countsByYear W27439192502022 @default.
• W2743919250 countsByYear W27439192502023 @default.
• W2743919250 crossrefType "journal-article" @default.
• W2743919250 hasAuthorship W2743919250A5026534555 @default.
• W2743919250 hasAuthorship W2743919250A5061709478 @default.
• W2743919250 hasAuthorship W2743919250A5062117439 @default.
• W2743919250 hasAuthorship W2743919250A5063759410 @default.
• W2743919250 hasConcept C108625454 @default.
• W2743919250 hasConcept C119062480 @default.
• W2743919250 hasConcept C121608353 @default.
• W2743919250 hasConcept C153911025 @default.
• W2743919250 hasConcept C158617107 @default.
• W2743919250 hasConcept C161019410 @default.
• W2743919250 hasConcept C181199279 @default.
• W2743919250 hasConcept C185592680 @default.
• W2743919250 hasConcept C206212055 @default.
• W2743919250 hasConcept C2775887612 @default.
• W2743919250 hasConcept C2777174400 @default.
• W2743919250 hasConcept C2779723316 @default.
• W2743919250 hasConcept C2780192828 @default.
• W2743919250 hasConcept C54355233 @default.
• W2743919250 hasConcept C55493867 @default.
• W2743919250 hasConcept C86803240 @default.
• W2743919250 hasConcept C95444343 @default.
• W2743919250 hasConceptScore W2743919250C108625454 @default.
• W2743919250 hasConceptScore W2743919250C119062480 @default.
• W2743919250 hasConceptScore W2743919250C121608353 @default.
• W2743919250 hasConceptScore W2743919250C153911025 @default.
• W2743919250 hasConceptScore W2743919250C158617107 @default.
• W2743919250 hasConceptScore W2743919250C161019410 @default.
• W2743919250 hasConceptScore W2743919250C181199279 @default.
• W2743919250 hasConceptScore W2743919250C185592680 @default.
• W2743919250 hasConceptScore W2743919250C206212055 @default.
• W2743919250 hasConceptScore W2743919250C2775887612 @default.
• W2743919250 hasConceptScore W2743919250C2777174400 @default.
• W2743919250 hasConceptScore W2743919250C2779723316 @default.
• W2743919250 hasConceptScore W2743919250C2780192828 @default.
• W2743919250 hasConceptScore W2743919250C54355233 @default.
• W2743919250 hasConceptScore W2743919250C55493867 @default.
• W2743919250 hasConceptScore W2743919250C86803240 @default.

• next