FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2743944837> ?p ?o ?g. }

• W2743944837 endingPage "3940" @default.
• W2743944837 startingPage "3925" @default.
• W2743944837 abstract "Bystander signaling via oxidative metabolism Humaira Aziz Sawal,1 Kashif Asghar,2 Matthias Bureik,3 Nasir Jalal4 1Healthcare Biotechnology Department, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, 2Basic Sciences Research, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan; 3Health Science Platform, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China; 4Health Science Platform, Department of Molecular and Cellular Pharmacology, Tianjin University, Tianjin, China Abstract: The radiation-induced bystander effect (RIBE) is the initiation of biological end points in cells (bystander cells) that are not directly traversed by an incident-radiation track, but are in close proximity to cells that are receiving the radiation. RIBE has been indicted of causing DNA damage via oxidative stress, besides causing direct damage, inducing tumorigenesis, producing micronuclei, and causing apoptosis. RIBE is regulated by signaling proteins that are either endogenous or secreted by cells as a means of communication between cells, and can activate intracellular or intercellular oxidative metabolism that can further trigger signaling pathways of inflammation. Bystander signals can pass through gap junctions in attached cell lines, while the suspended cell lines transmit these signals via hormones and soluble proteins. This review provides the background information on how reactive oxygen species (ROS) act as bystander signals. Although ROS have a very short half-life and have a nanometer-scale sphere of influence, the wide variety of ROS produced via various sources can exert a cumulative effect, not only in forming DNA adducts but also setting up signaling pathways of inflammation, apoptosis, cell-cycle arrest, aging, and even tumorigenesis. This review outlines the sources of the bystander effect linked to ROS in a cell, and provides methods of investigation for researchers who would like to pursue this field of science. Keywords: radiation-induced bystander effect (RIBE), reactive oxygen species (ROS), oxidative stress, bystander signaling, tumorigenesis&nbsp" @default.
• W2743944837 created "2017-08-17" @default.
• W2743944837 creator A5007736294 @default.
• W2743944837 creator A5051127711 @default.
• W2743944837 creator A5075356158 @default.
• W2743944837 creator A5076098532 @default.
• W2743944837 date "2017-08-01" @default.
• W2743944837 modified "2023-10-01" @default.
• W2743944837 title "Bystander signaling via oxidative metabolism" @default.
• W2743944837 cites W122658302 @default.
• W2743944837 cites W1481654951 @default.
• W2743944837 cites W1508418370 @default.
• W2743944837 cites W1512986985 @default.
• W2743944837 cites W1532212858 @default.
• W2743944837 cites W1536112481 @default.
• W2743944837 cites W1539131628 @default.
• W2743944837 cites W1546149770 @default.
• W2743944837 cites W1562310953 @default.
• W2743944837 cites W1595993343 @default.
• W2743944837 cites W1596431542 @default.
• W2743944837 cites W1761291408 @default.
• W2743944837 cites W1822009033 @default.
• W2743944837 cites W1860140559 @default.
• W2743944837 cites W1888056390 @default.
• W2743944837 cites W1942750313 @default.
• W2743944837 cites W1963863807 @default.
• W2743944837 cites W1965170368 @default.
• W2743944837 cites W1967276177 @default.
• W2743944837 cites W1967985735 @default.
• W2743944837 cites W1968400590 @default.
• W2743944837 cites W1969269292 @default.
• W2743944837 cites W1969846721 @default.
• W2743944837 cites W1974505849 @default.
• W2743944837 cites W1980739328 @default.
• W2743944837 cites W1982379443 @default.
• W2743944837 cites W1982778124 @default.
• W2743944837 cites W1983128520 @default.
• W2743944837 cites W1983338479 @default.
• W2743944837 cites W1983571732 @default.
• W2743944837 cites W1985152937 @default.
• W2743944837 cites W1985486659 @default.
• W2743944837 cites W1985517047 @default.
• W2743944837 cites W1985652307 @default.
• W2743944837 cites W1987704635 @default.
• W2743944837 cites W1989175790 @default.
• W2743944837 cites W1991601900 @default.
• W2743944837 cites W1991812553 @default.
• W2743944837 cites W1999294081 @default.
• W2743944837 cites W2002630124 @default.
• W2743944837 cites W2002769318 @default.
• W2743944837 cites W2003105919 @default.
• W2743944837 cites W2006555539 @default.
• W2743944837 cites W2007180952 @default.
• W2743944837 cites W2007636933 @default.
• W2743944837 cites W2008574207 @default.
• W2743944837 cites W2008617419 @default.
• W2743944837 cites W2009911964 @default.
• W2743944837 cites W2010341202 @default.
• W2743944837 cites W2012635889 @default.
• W2743944837 cites W2014335678 @default.
• W2743944837 cites W2019095153 @default.
• W2743944837 cites W2019128519 @default.
• W2743944837 cites W2019411611 @default.
• W2743944837 cites W2020428941 @default.
• W2743944837 cites W2024781204 @default.
• W2743944837 cites W2024833545 @default.
• W2743944837 cites W2024846369 @default.
• W2743944837 cites W2027879878 @default.
• W2743944837 cites W2027888373 @default.
• W2743944837 cites W2028400651 @default.
• W2743944837 cites W2028502692 @default.
• W2743944837 cites W2034158880 @default.
• W2743944837 cites W2034682638 @default.
• W2743944837 cites W2034711771 @default.
• W2743944837 cites W2037509005 @default.
• W2743944837 cites W2038758189 @default.
• W2743944837 cites W2039908717 @default.
• W2743944837 cites W2044886753 @default.
• W2743944837 cites W2046723353 @default.
• W2743944837 cites W2048082736 @default.
• W2743944837 cites W2048553024 @default.
• W2743944837 cites W2050658186 @default.
• W2743944837 cites W2051789180 @default.
• W2743944837 cites W2052432571 @default.
• W2743944837 cites W2054133295 @default.
• W2743944837 cites W2057433961 @default.
• W2743944837 cites W2059793781 @default.
• W2743944837 cites W2060057454 @default.
• W2743944837 cites W2062252146 @default.
• W2743944837 cites W2062559647 @default.
• W2743944837 cites W2065563959 @default.
• W2743944837 cites W2067278135 @default.
• W2743944837 cites W2069349400 @default.
• W2743944837 cites W2070555034 @default.
• W2743944837 cites W2072928113 @default.
• W2743944837 cites W2074048144 @default.
• W2743944837 cites W2075704804 @default.
• W2743944837 cites W2077806118 @default.

• next