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- W2744040852 abstract "RAS genes are mutated in 5%-40% of a spectrum of myeloid and lymphoid cancers with NRAS affected 2-3 times more often than KRAS Genomic analysis indicates that RAS mutations generally occur as secondary events in leukemogenesis, but are integral to the disease phenotype. The tractable nature of the hematopoietic system has facilitated generating accurate mouse models of hematologic malignancies characterized by hyperactive Ras signaling. These strains provide robust platforms for addressing how oncogenic Ras expression perturbs proliferation, differentiation, and self-renewal programs in stem and progenitor cell populations, for testing potential therapies, and for investigating mechanisms of drug response and resistance. This review summarizes recent insights from key studies in mouse models of hematologic cancer that are broadly relevant for understanding Ras biology and for ongoing efforts to implement rational therapeutic strategies for cancers with oncogenic RAS mutations." @default.
- W2744040852 created "2017-08-17" @default.
- W2744040852 creator A5023734568 @default.
- W2744040852 creator A5029323586 @default.
- W2744040852 date "2017-08-04" @default.
- W2744040852 modified "2023-09-28" @default.
- W2744040852 title "Mechanistic and Preclinical Insights from Mouse Models of Hematologic Cancer Characterized by Hyperactive Ras" @default.
- W2744040852 cites W1672289351 @default.
- W2744040852 cites W1920829940 @default.
- W2744040852 cites W1940615461 @default.
- W2744040852 cites W1965995529 @default.
- W2744040852 cites W1971730089 @default.
- W2744040852 cites W1972903141 @default.
- W2744040852 cites W1973297092 @default.
- W2744040852 cites W1975887213 @default.
- W2744040852 cites W1976009942 @default.
- W2744040852 cites W1977420876 @default.
- W2744040852 cites W1979099484 @default.
- W2744040852 cites W1979996085 @default.
- W2744040852 cites W1984065010 @default.
- W2744040852 cites W1986384270 @default.
- W2744040852 cites W1993362540 @default.
- W2744040852 cites W1994491427 @default.
- W2744040852 cites W1994772304 @default.
- W2744040852 cites W1995995993 @default.
- W2744040852 cites W1996692397 @default.
- W2744040852 cites W2005873273 @default.
- W2744040852 cites W2006917576 @default.
- W2744040852 cites W2008718421 @default.
- W2744040852 cites W2016329514 @default.
- W2744040852 cites W2017349699 @default.
- W2744040852 cites W2017444651 @default.
- W2744040852 cites W2020990571 @default.
- W2744040852 cites W2021022442 @default.
- W2744040852 cites W2023795819 @default.
- W2744040852 cites W2027254311 @default.
- W2744040852 cites W2032078881 @default.
- W2744040852 cites W2034848222 @default.
- W2744040852 cites W2034886137 @default.
- W2744040852 cites W2035736323 @default.
- W2744040852 cites W2037717289 @default.
- W2744040852 cites W2038970416 @default.
- W2744040852 cites W2042612710 @default.
- W2744040852 cites W2043160859 @default.
- W2744040852 cites W2044210875 @default.
- W2744040852 cites W2052600649 @default.
- W2744040852 cites W2055521874 @default.
- W2744040852 cites W2056960087 @default.
- W2744040852 cites W2060605982 @default.
- W2744040852 cites W2063662864 @default.
- W2744040852 cites W2068291467 @default.
- W2744040852 cites W2070287558 @default.
- W2744040852 cites W2073998405 @default.
- W2744040852 cites W2076031927 @default.
- W2744040852 cites W2076300336 @default.
- W2744040852 cites W2076372887 @default.
- W2744040852 cites W2077730236 @default.
- W2744040852 cites W2086373053 @default.
- W2744040852 cites W2087533846 @default.
- W2744040852 cites W2087734794 @default.
- W2744040852 cites W2088293068 @default.
- W2744040852 cites W2104582156 @default.
- W2744040852 cites W2107027906 @default.
- W2744040852 cites W2113770263 @default.
- W2744040852 cites W2118917726 @default.
- W2744040852 cites W2122659245 @default.
- W2744040852 cites W2123653028 @default.
- W2744040852 cites W2129129812 @default.
- W2744040852 cites W2129901774 @default.
- W2744040852 cites W2131444433 @default.
- W2744040852 cites W2143750439 @default.
- W2744040852 cites W2146340625 @default.
- W2744040852 cites W2147839086 @default.
- W2744040852 cites W2148965443 @default.
- W2744040852 cites W2154148265 @default.
- W2744040852 cites W2155586760 @default.
- W2744040852 cites W2159562139 @default.
- W2744040852 cites W2159594827 @default.
- W2744040852 cites W2162079601 @default.
- W2744040852 cites W2163395325 @default.
- W2744040852 cites W2166692731 @default.
- W2744040852 cites W2171383975 @default.
- W2744040852 cites W220016304 @default.
- W2744040852 cites W2205700110 @default.
- W2744040852 cites W2261929084 @default.
- W2744040852 cites W2296905683 @default.
- W2744040852 cites W23310454 @default.
- W2744040852 cites W2334045973 @default.
- W2744040852 cites W2337836604 @default.
- W2744040852 cites W2344142777 @default.
- W2744040852 cites W2409888422 @default.
- W2744040852 cites W2567378356 @default.
- W2744040852 cites W2584033231 @default.
- W2744040852 cites W2588498659 @default.
- W2744040852 cites W2588657480 @default.
- W2744040852 cites W2742294110 @default.
- W2744040852 cites W2766798501 @default.
- W2744040852 cites W2783231346 @default.
- W2744040852 cites W4229558181 @default.
- W2744040852 cites W4256451046 @default.