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• W2744051695 startingPage "e2967" @default.
• W2744051695 abstract "Abstract Inhibitors of apoptosis (IAP) proteins contribute to cell death resistance in malignancies and emerged as promising targets in cancer therapy. Currently, small molecules mimicking the IAP-antagonizing activity of endogenous second mitochondria-derived activator of caspases (SMAC) are evaluated in phase 1/2 clinical trials. In cancer cells, SMAC mimetic (SM)-mediated IAP depletion induces tumor necrosis factor (TNF) secretion and simultaneously sensitizes for TNF-induced cell death. However, tumor cells lacking SM-induced autocrine TNF release survive and thus limit therapeutic efficacy. Here, we show that hyperosmotic stress boosts SM cytotoxicity in human and murine cells through hypertonicity-induced upregulation of TNF with subsequent induction of apoptosis and/or necroptosis. Hypertonicity allowed robust TNF-dependent killing in SM-treated human acute lymphoblastic leukemia cells, which under isotonic conditions resisted SM treatment due to poor SM-induced TNF secretion. Mechanistically, hypertonicity-triggered TNF release bypassed the dependency on SM-induced TNF production to execute SM cytotoxicity, effectively reducing the role of SM to TNF-sensitizing, but not necessarily TNF-inducing agents. Perspectively, these findings could extend the clinical application of SM." @default.
• W2744051695 created "2017-08-17" @default.
• W2744051695 creator A5024432591 @default.
• W2744051695 creator A5073901072 @default.
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• W2744051695 date "2017-08-03" @default.
• W2744051695 modified "2023-10-07" @default.
• W2744051695 title "Hyperosmotic stress enhances cytotoxicity of SMAC mimetics" @default.
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• W2744051695 doi "https://doi.org/10.1038/cddis.2017.355" @default.
• W2744051695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5596546" @default.
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