FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744065619> ?p ?o ?g. }

• W2744065619 abstract "Abstract Prenatal hypoxia is associated with growth restriction and adverse cardiovascular outcomes. Here, we describe renal and cardiovascular outcomes in ageing mouse offspring prenatally exposed to hypoxia (12% O 2 ) from embryonic day 14.5 until birth. At 12 months of age, both male and female offspring exposed to prenatal hypoxia had elevated mean arterial pressure. Glomerular number was reduced by 25% in hypoxia-exposed male, but not female, offspring and this was associated with increased urinary albumin excretion, glomerular hypertrophy and renal fibrosis. Hypoxia-exposed offspring of both sexes were more susceptible to salt-induced cardiac fibrosis, however, renal fibrosis was exacerbated by high salt in males only. In male but not female hypoxia-exposed offspring, renal renin mRNA was increased at weaning. By 12 months, renal renin mRNA expression and concentrations were elevated in both sexes. mRNA expression of At 1a R was also elevated in male hypoxia-exposed offspring at 12 months. These results demonstrate that prenatal hypoxia programs elevated blood pressure and exacerbates salt-induced cardiovascular and renal pathology in a sex specific manner. Given sex differences observed in RAS expression and nephron number, future studies may consider RAS blockade as a therapeutic target in this model." @default.
• W2744065619 created "2017-08-17" @default.
• W2744065619 creator A5024853367 @default.
• W2744065619 creator A5026506282 @default.
• W2744065619 creator A5031007349 @default.
• W2744065619 creator A5040745079 @default.
• W2744065619 creator A5044303668 @default.
• W2744065619 creator A5047841130 @default.
• W2744065619 creator A5055500460 @default.
• W2744065619 date "2017-08-15" @default.
• W2744065619 modified "2023-09-26" @default.
• W2744065619 title "Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner" @default.
• W2744065619 cites W1515485668 @default.
• W2744065619 cites W1875915783 @default.
• W2744065619 cites W1948854550 @default.
• W2744065619 cites W1963528868 @default.
• W2744065619 cites W1978975856 @default.
• W2744065619 cites W1982976290 @default.
• W2744065619 cites W1984191137 @default.
• W2744065619 cites W1993387098 @default.
• W2744065619 cites W2008270224 @default.
• W2744065619 cites W2021704352 @default.
• W2744065619 cites W2042344849 @default.
• W2744065619 cites W2044185652 @default.
• W2744065619 cites W2046709463 @default.
• W2744065619 cites W2047632739 @default.
• W2744065619 cites W2052982466 @default.
• W2744065619 cites W2057830911 @default.
• W2744065619 cites W2064681431 @default.
• W2744065619 cites W2067715355 @default.
• W2744065619 cites W2072075701 @default.
• W2744065619 cites W2076013115 @default.
• W2744065619 cites W2086172425 @default.
• W2744065619 cites W2089239561 @default.
• W2744065619 cites W2096557697 @default.
• W2744065619 cites W2101842912 @default.
• W2744065619 cites W2104434982 @default.
• W2744065619 cites W2105026476 @default.
• W2744065619 cites W2107031719 @default.
• W2744065619 cites W2114953276 @default.
• W2744065619 cites W2123007594 @default.
• W2744065619 cites W2123835710 @default.
• W2744065619 cites W2126189493 @default.
• W2744065619 cites W2133469843 @default.
• W2744065619 cites W2138636041 @default.
• W2744065619 cites W2139353011 @default.
• W2744065619 cites W2143365093 @default.
• W2744065619 cites W2145705566 @default.
• W2744065619 cites W2149809974 @default.
• W2744065619 cites W2154301407 @default.
• W2744065619 cites W2157908571 @default.
• W2744065619 cites W2159793446 @default.
• W2744065619 cites W2160704068 @default.
• W2744065619 cites W2171437305 @default.
• W2744065619 cites W2343518861 @default.
• W2744065619 cites W2414348295 @default.
• W2744065619 cites W2426244986 @default.
• W2744065619 cites W2507442982 @default.
• W2744065619 cites W2564711365 @default.
• W2744065619 cites W2613483874 @default.
• W2744065619 cites W4254913758 @default.
• W2744065619 cites W80391022 @default.
• W2744065619 cites W94518081 @default.
• W2744065619 doi "https://doi.org/10.1038/s41598-017-08365-4" @default.
• W2744065619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5557956" @default.
• W2744065619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28811528" @default.
• W2744065619 hasPublicationYear "2017" @default.
• W2744065619 type Work @default.
• W2744065619 sameAs 2744065619 @default.
• W2744065619 citedByCount "35" @default.
• W2744065619 countsByYear W27440656192017 @default.
• W2744065619 countsByYear W27440656192018 @default.
• W2744065619 countsByYear W27440656192019 @default.
• W2744065619 countsByYear W27440656192020 @default.
• W2744065619 countsByYear W27440656192021 @default.
• W2744065619 countsByYear W27440656192022 @default.
• W2744065619 countsByYear W27440656192023 @default.
• W2744065619 crossrefType "journal-article" @default.
• W2744065619 hasAuthorship W2744065619A5024853367 @default.
• W2744065619 hasAuthorship W2744065619A5026506282 @default.
• W2744065619 hasAuthorship W2744065619A5031007349 @default.
• W2744065619 hasAuthorship W2744065619A5040745079 @default.
• W2744065619 hasAuthorship W2744065619A5044303668 @default.
• W2744065619 hasAuthorship W2744065619A5047841130 @default.
• W2744065619 hasAuthorship W2744065619A5055500460 @default.
• W2744065619 hasBestOaLocation W27440656191 @default.
• W2744065619 hasConcept C112672928 @default.
• W2744065619 hasConcept C126322002 @default.
• W2744065619 hasConcept C133397671 @default.
• W2744065619 hasConcept C134018914 @default.
• W2744065619 hasConcept C178790620 @default.
• W2744065619 hasConcept C185592680 @default.
• W2744065619 hasConcept C198710026 @default.
• W2744065619 hasConcept C2779234561 @default.
• W2744065619 hasConcept C2780091579 @default.
• W2744065619 hasConcept C2780559512 @default.
• W2744065619 hasConcept C2781231759 @default.
• W2744065619 hasConcept C540031477 @default.
• W2744065619 hasConcept C54355233 @default.
• W2744065619 hasConcept C71924100 @default.

• next