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• W2744160419 abstract "Significance The immune system is important for host defense against invading pathogens by producing proinflammatory cytokines and IFNs. IL-12 is a vital proinflammatory cytokine that combines innate immunity with adaptive immunity. In our study, we find that CA-VI B preferentially expressed in macrophages can interact with PRMT5, consequently suppressing H3R8me2s modification in Il12 promoters to promote IL-12 production to trigger an antibacterial immune response. Our study adds insight about the function of CA family members in innate immune response by selectively inducing cytokine IL-12 production through regulating histone arginine modification, which is independent of its carbonic anhydrase activity." @default.
• W2744160419 created "2017-08-17" @default.
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• W2744160419 date "2017-07-24" @default.
• W2744160419 modified "2023-10-10" @default.
• W2744160419 title "Nuclear carbonic anhydrase 6B associates with PRMT5 to epigenetically promote IL-12 expression in innate response" @default.
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• W2744160419 doi "https://doi.org/10.1073/pnas.1700917114" @default.
• W2744160419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5559001" @default.
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