FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744161479> ?p ?o ?g. }

• W2744161479 abstract "Abstract Metronomic chemotherapy involves the administration of cytotoxic chemotherapy at reduced doses administered at regular and frequent intervals. Low-dose metronomic (LDM) chemotherapy represents an alternative to standard maximum tolerated dose (MTD) chemotherapy as it is less toxic and offers additional beneficial biological effects; such effects include inhibition of tumor neovascularization and reduced recruitment of immune-suppressive cells. In desmoplastic cancers such as breast and pancreatic cancers, carcinoma-associated fibroblasts (CAFs) in the tumor stroma constitute an important cellular target of systemic chemotherapy, and the treatment-modulated CAFs may deleteriously influence treatment efficacy. Herein, we reviewed the novel roles of CAFs in metronomic chemotherapy in desmoplastic cancers. We discuss the differential effects of MTD- and LDM-chemotherapy on the heterotypic interactions among CAFs and cells in the other cancer compartments, emphasizing the roles of cancer stem cells and myeloid-derived suppressor cells. The novel mechanistic roles of CAFs in cancer therapy provide an additional rationale for the clinical development of LDM chemotherapy." @default.
• W2744161479 created "2017-08-17" @default.
• W2744161479 creator A5026360770 @default.
• W2744161479 creator A5057757156 @default.
• W2744161479 creator A5089538326 @default.
• W2744161479 date "2017-12-01" @default.
• W2744161479 modified "2023-10-14" @default.
• W2744161479 title "The novel roles of stromal fibroblasts in metronomic chemotherapy: Focusing on cancer stemness and immunity" @default.
• W2744161479 cites W1556819620 @default.
• W2744161479 cites W1668963162 @default.
• W2744161479 cites W1767508090 @default.
• W2744161479 cites W1965648876 @default.
• W2744161479 cites W1979235929 @default.
• W2744161479 cites W1985549756 @default.
• W2744161479 cites W1989025666 @default.
• W2744161479 cites W1991722547 @default.
• W2744161479 cites W1993875664 @default.
• W2744161479 cites W1999356404 @default.
• W2744161479 cites W2014124238 @default.
• W2744161479 cites W2030059329 @default.
• W2744161479 cites W2032941886 @default.
• W2744161479 cites W2038218634 @default.
• W2744161479 cites W2038918212 @default.
• W2744161479 cites W2051250007 @default.
• W2744161479 cites W2060185596 @default.
• W2744161479 cites W2060469376 @default.
• W2744161479 cites W2060672294 @default.
• W2744161479 cites W2062069198 @default.
• W2744161479 cites W2071123870 @default.
• W2744161479 cites W2090806526 @default.
• W2744161479 cites W2095320189 @default.
• W2744161479 cites W2102944868 @default.
• W2744161479 cites W2113586126 @default.
• W2744161479 cites W2115585914 @default.
• W2744161479 cites W2123242217 @default.
• W2744161479 cites W2130870648 @default.
• W2744161479 cites W2133075384 @default.
• W2744161479 cites W2138326965 @default.
• W2744161479 cites W2144325011 @default.
• W2744161479 cites W2151832198 @default.
• W2744161479 cites W2152387543 @default.
• W2744161479 cites W2152897456 @default.
• W2744161479 cites W2160245658 @default.
• W2744161479 cites W2169083371 @default.
• W2744161479 cites W2171524684 @default.
• W2744161479 cites W2279561773 @default.
• W2744161479 cites W2329768139 @default.
• W2744161479 cites W2344732859 @default.
• W2744161479 cites W2400022769 @default.
• W2744161479 cites W2416038770 @default.
• W2744161479 cites W2509111028 @default.
• W2744161479 cites W2511743252 @default.
• W2744161479 cites W2551893887 @default.
• W2744161479 cites W2554432126 @default.
• W2744161479 cites W3021664385 @default.
• W2744161479 doi "https://doi.org/10.1016/j.jcrpr.2017.08.001" @default.
• W2744161479 hasPublicationYear "2017" @default.
• W2744161479 type Work @default.
• W2744161479 sameAs 2744161479 @default.
• W2744161479 citedByCount "0" @default.
• W2744161479 crossrefType "journal-article" @default.
• W2744161479 hasAuthorship W2744161479A5026360770 @default.
• W2744161479 hasAuthorship W2744161479A5057757156 @default.
• W2744161479 hasAuthorship W2744161479A5089538326 @default.
• W2744161479 hasBestOaLocation W27441614791 @default.
• W2744161479 hasConcept C121608353 @default.
• W2744161479 hasConcept C126322002 @default.
• W2744161479 hasConcept C143998085 @default.
• W2744161479 hasConcept C16930146 @default.
• W2744161479 hasConcept C203014093 @default.
• W2744161479 hasConcept C204232928 @default.
• W2744161479 hasConcept C2776107976 @default.
• W2744161479 hasConcept C2776694085 @default.
• W2744161479 hasConcept C28328180 @default.
• W2744161479 hasConcept C2909706936 @default.
• W2744161479 hasConcept C502942594 @default.
• W2744161479 hasConcept C52124034 @default.
• W2744161479 hasConcept C530470458 @default.
• W2744161479 hasConcept C54355233 @default.
• W2744161479 hasConcept C71924100 @default.
• W2744161479 hasConcept C86803240 @default.
• W2744161479 hasConcept C8891405 @default.
• W2744161479 hasConcept C96232424 @default.
• W2744161479 hasConceptScore W2744161479C121608353 @default.
• W2744161479 hasConceptScore W2744161479C126322002 @default.
• W2744161479 hasConceptScore W2744161479C143998085 @default.
• W2744161479 hasConceptScore W2744161479C16930146 @default.
• W2744161479 hasConceptScore W2744161479C203014093 @default.
• W2744161479 hasConceptScore W2744161479C204232928 @default.
• W2744161479 hasConceptScore W2744161479C2776107976 @default.
• W2744161479 hasConceptScore W2744161479C2776694085 @default.
• W2744161479 hasConceptScore W2744161479C28328180 @default.
• W2744161479 hasConceptScore W2744161479C2909706936 @default.
• W2744161479 hasConceptScore W2744161479C502942594 @default.
• W2744161479 hasConceptScore W2744161479C52124034 @default.
• W2744161479 hasConceptScore W2744161479C530470458 @default.
• W2744161479 hasConceptScore W2744161479C54355233 @default.
• W2744161479 hasConceptScore W2744161479C71924100 @default.
• W2744161479 hasConceptScore W2744161479C86803240 @default.
• W2744161479 hasConceptScore W2744161479C8891405 @default.

• next