FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744204310> ?p ?o ?g. }

• W2744204310 endingPage "475" @default.
• W2744204310 startingPage "472" @default.
• W2744204310 abstract "Removing orphan proteins from the system The degradation of excess subunits of protein complexes is a major quality-control problem for the cell. How such “orphans” are recognized and tagged for degradation is poorly understood. Two papers identify a protein quality-control pathway that acts on some of the most abundant protein complexes in the human body: hemoglobin and ribosomes (see the Perspective by Hampton and Dargemont). Yanagitani et al. show that the central player in this process is an unusual enzyme (UBE2O) that recognizes substrates and tags them for destruction. Other quality-contr ol pathways tend to use separate factors for target selection (often a chaperone), ubiquitin donation (an E2), and ubiquitin conjugati on (an E3). Encoding all three activities in a single factor whose function can be reconstituted in a purified system provides a tractable route to detailed mechanistic and structural dissection. Nguyen et al. show the importance of the UBE2O pathway in the differentiation of red blood cells. Science , this issue p. 472 , p. 471 ; see also p. 450" @default.
• W2744204310 created "2017-08-17" @default.
• W2744204310 creator A5007776918 @default.
• W2744204310 creator A5025080415 @default.
• W2744204310 creator A5032523525 @default.
• W2744204310 date "2017-08-04" @default.
• W2744204310 modified "2023-10-17" @default.
• W2744204310 title "UBE2O is a quality control factor for orphans of multiprotein complexes" @default.
• W2744204310 cites W1911847067 @default.
• W2744204310 cites W1968389207 @default.
• W2744204310 cites W1973335538 @default.
• W2744204310 cites W1974702668 @default.
• W2744204310 cites W1977502249 @default.
• W2744204310 cites W1982757612 @default.
• W2744204310 cites W1983863167 @default.
• W2744204310 cites W2007003700 @default.
• W2744204310 cites W2012618006 @default.
• W2744204310 cites W2017284082 @default.
• W2744204310 cites W2019427635 @default.
• W2744204310 cites W2040029052 @default.
• W2744204310 cites W2043586610 @default.
• W2744204310 cites W2047936494 @default.
• W2744204310 cites W2050721857 @default.
• W2744204310 cites W2057565092 @default.
• W2744204310 cites W2061659241 @default.
• W2744204310 cites W2077243151 @default.
• W2744204310 cites W2077457197 @default.
• W2744204310 cites W2082382374 @default.
• W2744204310 cites W2116117181 @default.
• W2744204310 cites W2118886634 @default.
• W2744204310 cites W21200892 @default.
• W2744204310 cites W2121220280 @default.
• W2744204310 cites W2152231829 @default.
• W2744204310 cites W2162980545 @default.
• W2744204310 cites W2169755861 @default.
• W2744204310 cites W2258936965 @default.
• W2744204310 cites W2469126442 @default.
• W2744204310 cites W2471197399 @default.
• W2744204310 cites W2511774689 @default.
• W2744204310 cites W2518899399 @default.
• W2744204310 cites W2529263647 @default.
• W2744204310 cites W2549527258 @default.
• W2744204310 cites W2553087578 @default.
• W2744204310 cites W2568866823 @default.
• W2744204310 cites W2571305783 @default.
• W2744204310 cites W2575766838 @default.
• W2744204310 cites W2583295063 @default.
• W2744204310 cites W2743753720 @default.
• W2744204310 cites W4253791261 @default.
• W2744204310 doi "https://doi.org/10.1126/science.aan0178" @default.
• W2744204310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5549844" @default.
• W2744204310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28774922" @default.
• W2744204310 hasPublicationYear "2017" @default.
• W2744204310 type Work @default.
• W2744204310 sameAs 2744204310 @default.
• W2744204310 citedByCount "91" @default.
• W2744204310 countsByYear W27442043102017 @default.
• W2744204310 countsByYear W27442043102018 @default.
• W2744204310 countsByYear W27442043102019 @default.
• W2744204310 countsByYear W27442043102020 @default.
• W2744204310 countsByYear W27442043102021 @default.
• W2744204310 countsByYear W27442043102022 @default.
• W2744204310 countsByYear W27442043102023 @default.
• W2744204310 crossrefType "journal-article" @default.
• W2744204310 hasAuthorship W2744204310A5007776918 @default.
• W2744204310 hasAuthorship W2744204310A5025080415 @default.
• W2744204310 hasAuthorship W2744204310A5032523525 @default.
• W2744204310 hasBestOaLocation W27442043101 @default.
• W2744204310 hasConcept C104317684 @default.
• W2744204310 hasConcept C142724271 @default.
• W2744204310 hasConcept C185592680 @default.
• W2744204310 hasConcept C25602115 @default.
• W2744204310 hasConcept C2775962898 @default.
• W2744204310 hasConcept C2992195973 @default.
• W2744204310 hasConcept C54355233 @default.
• W2744204310 hasConcept C55493867 @default.
• W2744204310 hasConcept C70721500 @default.
• W2744204310 hasConcept C71924100 @default.
• W2744204310 hasConcept C84982370 @default.
• W2744204310 hasConcept C86803240 @default.
• W2744204310 hasConcept C95444343 @default.
• W2744204310 hasConceptScore W2744204310C104317684 @default.
• W2744204310 hasConceptScore W2744204310C142724271 @default.
• W2744204310 hasConceptScore W2744204310C185592680 @default.
• W2744204310 hasConceptScore W2744204310C25602115 @default.
• W2744204310 hasConceptScore W2744204310C2775962898 @default.
• W2744204310 hasConceptScore W2744204310C2992195973 @default.
• W2744204310 hasConceptScore W2744204310C54355233 @default.
• W2744204310 hasConceptScore W2744204310C55493867 @default.
• W2744204310 hasConceptScore W2744204310C70721500 @default.
• W2744204310 hasConceptScore W2744204310C71924100 @default.
• W2744204310 hasConceptScore W2744204310C84982370 @default.
• W2744204310 hasConceptScore W2744204310C86803240 @default.
• W2744204310 hasConceptScore W2744204310C95444343 @default.
• W2744204310 hasFunder F4320310760 @default.
• W2744204310 hasFunder F4320334626 @default.
• W2744204310 hasFunder F4320334764 @default.
• W2744204310 hasIssue "6350" @default.

• next