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- W2744280566 endingPage "3447" @default.
- W2744280566 startingPage "3435" @default.
- W2744280566 abstract "In utero exposure to the endocrine disrupting compound bisphenol A (BPA) is known to disrupt mammary gland development and increase tumor susceptibility in rodents. It is unclear whether different periods of in utero development might be more susceptible to BPA exposure. We exposed pregnant CD-1 mice to BPA at different times during gestation that correspond to specific milestones of in utero mammary gland development. The mammary glands of early-life and adult female mice, exposed in utero to BPA, were morphologically and molecularly (estrogen receptor-α and Ki67) evaluated for developmental abnormalities. We found that BPA treatment occurring before mammary bud invasion into the mesenchyme [embryonic day (E)12.5] incompletely resulted in the measured phenotypes of mammary gland defects. Exposing mice up to the point at which the epithelium extends into the precursor fat pad (E16.5) resulted in a nearly complete BPA phenotype and exposure during epithelial extension (E15.5 to E18.5) resulted in a partial phenotype. Furthermore, the relative differences in phenotypes between exposure windows highlight the substantial correlations between early-life molecular changes (estrogen receptor-α and Ki67) in the stroma and the epithelial elongation defects in mammary development. These data further implicate BPA action in the stroma as a critical mediator of epithelial phenotypes." @default.
- W2744280566 created "2017-08-17" @default.
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- W2744280566 date "2017-08-09" @default.
- W2744280566 modified "2023-10-01" @default.
- W2744280566 title "Varying Susceptibility of the Female Mammary Gland to In Utero Windows of BPA Exposure" @default.
- W2744280566 cites W1217425532 @default.
- W2744280566 cites W1234520200 @default.
- W2744280566 cites W1512733937 @default.
- W2744280566 cites W1549695464 @default.
- W2744280566 cites W155326310 @default.
- W2744280566 cites W1562900399 @default.
- W2744280566 cites W1568892636 @default.
- W2744280566 cites W1863544056 @default.
- W2744280566 cites W1916536208 @default.
- W2744280566 cites W1964537575 @default.
- W2744280566 cites W1969429213 @default.
- W2744280566 cites W1976308170 @default.
- W2744280566 cites W1981014442 @default.
- W2744280566 cites W1984254033 @default.
- W2744280566 cites W1989873377 @default.
- W2744280566 cites W1990924578 @default.
- W2744280566 cites W1995821399 @default.
- W2744280566 cites W1997474221 @default.
- W2744280566 cites W1998135404 @default.
- W2744280566 cites W2000557258 @default.
- W2744280566 cites W2002286050 @default.
- W2744280566 cites W2007497599 @default.
- W2744280566 cites W2011451538 @default.
- W2744280566 cites W2012425172 @default.
- W2744280566 cites W2014157399 @default.
- W2744280566 cites W2019868204 @default.
- W2744280566 cites W2025211988 @default.
- W2744280566 cites W2039711181 @default.
- W2744280566 cites W2041101473 @default.
- W2744280566 cites W2042412547 @default.
- W2744280566 cites W2046280877 @default.
- W2744280566 cites W2049065981 @default.
- W2744280566 cites W2051009756 @default.
- W2744280566 cites W2054267961 @default.
- W2744280566 cites W2056456647 @default.
- W2744280566 cites W2059392150 @default.
- W2744280566 cites W2060880435 @default.
- W2744280566 cites W2062808994 @default.
- W2744280566 cites W2062847019 @default.
- W2744280566 cites W2067753015 @default.
- W2744280566 cites W2068104926 @default.
- W2744280566 cites W2073726509 @default.
- W2744280566 cites W2074964991 @default.
- W2744280566 cites W2075443461 @default.
- W2744280566 cites W2076588421 @default.
- W2744280566 cites W2094088441 @default.
- W2744280566 cites W2094915911 @default.
- W2744280566 cites W2096022216 @default.
- W2744280566 cites W2096790979 @default.
- W2744280566 cites W2098440133 @default.
- W2744280566 cites W2099702361 @default.
- W2744280566 cites W2105615579 @default.
- W2744280566 cites W2109879710 @default.
- W2744280566 cites W2112620557 @default.
- W2744280566 cites W2113625426 @default.
- W2744280566 cites W2114990515 @default.
- W2744280566 cites W2115436357 @default.
- W2744280566 cites W2122070595 @default.
- W2744280566 cites W2122855814 @default.
- W2744280566 cites W2123624930 @default.
- W2744280566 cites W2127567198 @default.
- W2744280566 cites W2128451505 @default.
- W2744280566 cites W2135752342 @default.
- W2744280566 cites W2141140569 @default.
- W2744280566 cites W2145926321 @default.
- W2744280566 cites W2146945066 @default.
- W2744280566 cites W2147890019 @default.
- W2744280566 cites W2151063137 @default.
- W2744280566 cites W2153276715 @default.
- W2744280566 cites W2154794295 @default.
- W2744280566 cites W2160595898 @default.
- W2744280566 cites W2166415807 @default.
- W2744280566 cites W2168148786 @default.
- W2744280566 cites W2171809110 @default.
- W2744280566 cites W2321560226 @default.
- W2744280566 cites W2338935009 @default.
- W2744280566 cites W2418367501 @default.
- W2744280566 cites W24809142 @default.
- W2744280566 cites W2574339288 @default.
- W2744280566 cites W2902914441 @default.
- W2744280566 cites W312615944 @default.
- W2744280566 cites W4242580111 @default.
- W2744280566 cites W4250767132 @default.
- W2744280566 cites W66751140 @default.