Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744316099> ?p ?o ?g. }
- W2744316099 endingPage "e0182025" @default.
- W2744316099 startingPage "e0182025" @default.
- W2744316099 abstract "Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide. We validated the utility of plasma metabolomics analysis in the clinical diagnosis of acute TBI in a rat model of controlled cortical impact (CCI) using gas chromatography/mass spectrometry (GC/MS). Thirty Sprague-Dawley rats were randomly divided into two groups of 15 rats each: the CCI group and sham group. Blood samples were obtained from the rats within the first 24 h after TBI injury. GC/MS measurements were performed to evaluate the profile of acute TBI-induced metabolic changes, resulting in the identification of 45 metabolites in plasma. Principal component analysis, partial least squares-discriminant analysis, orthogonal partial least square discriminant analysis using hierarchical clustering and univariate/multivariate analyses revealed clear differences in the plasma metabolome between the acute CCI group and the sham group. CCI induced distinctive changes in metabolites including linoleic acid metabolism, amino acid metabolism, galactose metabolism, and arachidonic acid metabolism. Specifically, the acute CCI group exhibited significant alterations in proline, phosphoric acid, β-hydroxybutyric acid, galactose, creatinine, L-valine, linoleic acid and arachidonic acid. A receiver operating characteristic curve analysis showed that the above 8 metabolites in plasma could be used as the potential biomarkers for the diagnosis of acute TBI. Furthermore, this study is the first time to identify the galactose as a biomarker candidate for acute TBI. This comprehensive metabolic analysis complements target screening for potential diagnostic biomarkers of acute TBI and enhances predictive value for the therapeutic intervention of acute TBI." @default.
- W2744316099 created "2017-08-17" @default.
- W2744316099 creator A5014296177 @default.
- W2744316099 creator A5020408458 @default.
- W2744316099 creator A5021910535 @default.
- W2744316099 creator A5028306431 @default.
- W2744316099 creator A5040005400 @default.
- W2744316099 creator A5072204722 @default.
- W2744316099 creator A5087585454 @default.
- W2744316099 creator A5088340227 @default.
- W2744316099 creator A5091570311 @default.
- W2744316099 date "2017-08-03" @default.
- W2744316099 modified "2023-10-10" @default.
- W2744316099 title "Plasma metabolomics profiles in rats with acute traumatic brain injury" @default.
- W2744316099 cites W117484700 @default.
- W2744316099 cites W1255254263 @default.
- W2744316099 cites W1699212091 @default.
- W2744316099 cites W1914095771 @default.
- W2744316099 cites W1964919195 @default.
- W2744316099 cites W1968813633 @default.
- W2744316099 cites W1969082909 @default.
- W2744316099 cites W1973390472 @default.
- W2744316099 cites W1975473823 @default.
- W2744316099 cites W1978635921 @default.
- W2744316099 cites W1982862089 @default.
- W2744316099 cites W1986319316 @default.
- W2744316099 cites W1990014836 @default.
- W2744316099 cites W1991210201 @default.
- W2744316099 cites W1998513269 @default.
- W2744316099 cites W1999876711 @default.
- W2744316099 cites W2001829188 @default.
- W2744316099 cites W2004770795 @default.
- W2744316099 cites W2005779853 @default.
- W2744316099 cites W2017771330 @default.
- W2744316099 cites W2017932539 @default.
- W2744316099 cites W2020030788 @default.
- W2744316099 cites W2022234260 @default.
- W2744316099 cites W2026784589 @default.
- W2744316099 cites W2029784301 @default.
- W2744316099 cites W2032951220 @default.
- W2744316099 cites W2036069083 @default.
- W2744316099 cites W2039388025 @default.
- W2744316099 cites W2039466331 @default.
- W2744316099 cites W2040831881 @default.
- W2744316099 cites W2045006417 @default.
- W2744316099 cites W2046479752 @default.
- W2744316099 cites W2056143628 @default.
- W2744316099 cites W2060761887 @default.
- W2744316099 cites W2062222093 @default.
- W2744316099 cites W2062863161 @default.
- W2744316099 cites W2063558183 @default.
- W2744316099 cites W2066439519 @default.
- W2744316099 cites W2071581284 @default.
- W2744316099 cites W2071868850 @default.
- W2744316099 cites W2073814752 @default.
- W2744316099 cites W2077839757 @default.
- W2744316099 cites W2079539566 @default.
- W2744316099 cites W2080601011 @default.
- W2744316099 cites W2083239757 @default.
- W2744316099 cites W2088681575 @default.
- W2744316099 cites W2089517043 @default.
- W2744316099 cites W2097787145 @default.
- W2744316099 cites W2118523264 @default.
- W2744316099 cites W2128631895 @default.
- W2744316099 cites W2136508875 @default.
- W2744316099 cites W2152943013 @default.
- W2744316099 cites W2155680682 @default.
- W2744316099 cites W2182660811 @default.
- W2744316099 cites W2275287493 @default.
- W2744316099 cites W2276634227 @default.
- W2744316099 cites W2288811426 @default.
- W2744316099 cites W2289324525 @default.
- W2744316099 cites W2295820091 @default.
- W2744316099 cites W2313784025 @default.
- W2744316099 cites W2328176404 @default.
- W2744316099 cites W2346002027 @default.
- W2744316099 cites W2397461456 @default.
- W2744316099 cites W2410872573 @default.
- W2744316099 cites W2413525939 @default.
- W2744316099 cites W2497905540 @default.
- W2744316099 cites W2503505788 @default.
- W2744316099 cites W2509714450 @default.
- W2744316099 cites W2510805760 @default.
- W2744316099 cites W2519267651 @default.
- W2744316099 cites W2524598398 @default.
- W2744316099 cites W2536275306 @default.
- W2744316099 cites W2626011359 @default.
- W2744316099 cites W4211085285 @default.
- W2744316099 cites W4233865359 @default.
- W2744316099 cites W4294326454 @default.
- W2744316099 cites W572697538 @default.
- W2744316099 cites W618343152 @default.
- W2744316099 doi "https://doi.org/10.1371/journal.pone.0182025" @default.
- W2744316099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5542452" @default.
- W2744316099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28771528" @default.
- W2744316099 hasPublicationYear "2017" @default.
- W2744316099 type Work @default.
- W2744316099 sameAs 2744316099 @default.