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• W2744331291 abstract "// Chen Chen 1, * , Yusufu Maimaiti 2, * , Shen Zhijun 3 , Liu Zeming 1 , Guo Yawen 1 , Yu Pan 1 and Huang Tao 1 1 Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, P.R. China 2 Department of General Surgery (Research Institute of Minimally Invasive), People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, P.R. China 3 Clinical Laboratory, The Third People’s Hospital of Hubei Province, Wuhan 430000, P.R. China * These authors have contributed equally to this work Corresponding to: Huang Tao, email: huangtaowh@163.com Keywords: breast cancer, cofilin, slingshot, membrane protrusionm, actin dynamics Received: May 10, 2017     Accepted: June 28, 2017     Published: August 03, 2017 ABSTRACT Slingshot (SSH) is a member of the conserved family of cofilin phosphatases that plays a critical role in cell membrane protrusion and migration by transforming inactive phosphorylated cofilin to an active form. SSH-like protein 1 (SSH-1L) expression is detected in various types of tumors; insulin induces the phosphatases activity of SSH-1L in a phosphoinositide 3-kinase-dependent manner. However, little is known about the expression and role of SSH-1L in breast cancer. Here, we analyzed 295 human breast cancer tissue specimens for SSH-1L expression by immunohistochemistry. The correlation between SSH-1L level and patients’ clinical characteristics was analyzed with Pearson’s χ 2 test. The function of SSH-1L was evaluated by gene knockdown and quantitative real-time polymerase chain reaction detection of cofilin expression in MDA-MB-231, MCF-7, and SK-BR-3 human breast cancer cell lines. SSH-1L expression was detected in 88.1% of tissue specimens by immunohistochemistry and was strongly associated with increased metastasis and mortality. Loss of SSH-1L expression decreased the nonphosphorylated, active form of cofilin in SK-BR-3 and MDA-MB-231 cell lines, which was associated with reduced cell motility. Accordingly, SSH-1L/cofilin signaling played a critical role in primary breast cancer metastasis and was a potential therapeutic target for breast cancer treatment." @default.
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• W2744331291 date "2017-08-03" @default.
• W2744331291 modified "2023-09-26" @default.
• W2744331291 title "Slingshot-1L, a cofilin phosphatase, induces primary breast cancer metastasis" @default.
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• W2744331291 doi "https://doi.org/10.18632/oncotarget.19855" @default.
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