Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744331948> ?p ?o ?g. }
- W2744331948 endingPage "e1006568" @default.
- W2744331948 startingPage "e1006568" @default.
- W2744331948 abstract "The development of vaccines against fungi and other intracellular microbes is impeded in part by a lack of suitable adjuvants. While most current vaccines against infectious diseases preferentially induce production of antibodies, cellular immunity is essential for the resolution of fungal infections. Microbes such as fungi and Mycobacterium tuberculosis require Th17 and Th1 cells for resistance, and engage the C-type lectin receptors including Dectin-2. Herein, we discovered a novel Dectin-2 ligand, the glycoprotein Blastomyces Eng2 (Bl-Eng2). Bl-Eng2 triggers robust signaling in Dectin-2 reporter cells and induces IL-6 in human PBMC and BMDC from wild type but not Dectin-2-/- and Card9-/- mice. The addition of Bl-Eng2 to a pan-fungal subunit vaccine primed large numbers of Ag-specific Th17 and Th1 cells, augmented activation and killing of fungi by myeloid effector cells, and protected mice from lethal fungal challenge, revealing Bl-Eng2's potency as a vaccine adjuvant. Thus, ligation of Dectin-2 by Bl-Eng-2 could be harnessed as a novel adjuvant strategy to protect against infectious diseases requiring cellular immunity." @default.
- W2744331948 created "2017-08-17" @default.
- W2744331948 creator A5008382658 @default.
- W2744331948 creator A5010768212 @default.
- W2744331948 creator A5014486696 @default.
- W2744331948 creator A5032606873 @default.
- W2744331948 creator A5041704227 @default.
- W2744331948 creator A5046590073 @default.
- W2744331948 creator A5075007650 @default.
- W2744331948 creator A5075776936 @default.
- W2744331948 creator A5077326823 @default.
- W2744331948 date "2017-08-09" @default.
- W2744331948 modified "2023-10-15" @default.
- W2744331948 title "Ligation of Dectin-2 with a novel microbial ligand promotes adjuvant activity for vaccination" @default.
- W2744331948 cites W1597089068 @default.
- W2744331948 cites W1964465182 @default.
- W2744331948 cites W1975910541 @default.
- W2744331948 cites W1988204388 @default.
- W2744331948 cites W1988820663 @default.
- W2744331948 cites W1991323622 @default.
- W2744331948 cites W1994282287 @default.
- W2744331948 cites W1995969712 @default.
- W2744331948 cites W2002836781 @default.
- W2744331948 cites W2003564377 @default.
- W2744331948 cites W2017758723 @default.
- W2744331948 cites W2026106645 @default.
- W2744331948 cites W2026309565 @default.
- W2744331948 cites W2035011417 @default.
- W2744331948 cites W2045179022 @default.
- W2744331948 cites W2045279953 @default.
- W2744331948 cites W2052871190 @default.
- W2744331948 cites W2056450591 @default.
- W2744331948 cites W2076794463 @default.
- W2744331948 cites W2086105638 @default.
- W2744331948 cites W2087608197 @default.
- W2744331948 cites W2089984089 @default.
- W2744331948 cites W2094297464 @default.
- W2744331948 cites W2094786750 @default.
- W2744331948 cites W2095779036 @default.
- W2744331948 cites W2103640540 @default.
- W2744331948 cites W2107794472 @default.
- W2744331948 cites W2108822061 @default.
- W2744331948 cites W2111134819 @default.
- W2744331948 cites W2113576692 @default.
- W2744331948 cites W2125871798 @default.
- W2744331948 cites W2128984001 @default.
- W2744331948 cites W2129374849 @default.
- W2744331948 cites W2144514674 @default.
- W2744331948 cites W2145553590 @default.
- W2744331948 cites W2149297795 @default.
- W2744331948 cites W2151626638 @default.
- W2744331948 cites W2153555681 @default.
- W2744331948 cites W2160747036 @default.
- W2744331948 cites W2281295934 @default.
- W2744331948 cites W4232731588 @default.
- W2744331948 doi "https://doi.org/10.1371/journal.ppat.1006568" @default.
- W2744331948 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5565193" @default.
- W2744331948 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28793349" @default.
- W2744331948 hasPublicationYear "2017" @default.
- W2744331948 type Work @default.
- W2744331948 sameAs 2744331948 @default.
- W2744331948 citedByCount "24" @default.
- W2744331948 countsByYear W27443319482018 @default.
- W2744331948 countsByYear W27443319482019 @default.
- W2744331948 countsByYear W27443319482020 @default.
- W2744331948 countsByYear W27443319482021 @default.
- W2744331948 countsByYear W27443319482022 @default.
- W2744331948 countsByYear W27443319482023 @default.
- W2744331948 crossrefType "journal-article" @default.
- W2744331948 hasAuthorship W2744331948A5008382658 @default.
- W2744331948 hasAuthorship W2744331948A5010768212 @default.
- W2744331948 hasAuthorship W2744331948A5014486696 @default.
- W2744331948 hasAuthorship W2744331948A5032606873 @default.
- W2744331948 hasAuthorship W2744331948A5041704227 @default.
- W2744331948 hasAuthorship W2744331948A5046590073 @default.
- W2744331948 hasAuthorship W2744331948A5075007650 @default.
- W2744331948 hasAuthorship W2744331948A5075776936 @default.
- W2744331948 hasAuthorship W2744331948A5077326823 @default.
- W2744331948 hasBestOaLocation W27443319481 @default.
- W2744331948 hasConcept C116569031 @default.
- W2744331948 hasConcept C153911025 @default.
- W2744331948 hasConcept C170493617 @default.
- W2744331948 hasConcept C179437574 @default.
- W2744331948 hasConcept C185592680 @default.
- W2744331948 hasConcept C203014093 @default.
- W2744331948 hasConcept C22070199 @default.
- W2744331948 hasConcept C2777863537 @default.
- W2744331948 hasConcept C502942594 @default.
- W2744331948 hasConcept C55493867 @default.
- W2744331948 hasConcept C70721500 @default.
- W2744331948 hasConcept C71924100 @default.
- W2744331948 hasConcept C86803240 @default.
- W2744331948 hasConcept C89423630 @default.
- W2744331948 hasConceptScore W2744331948C116569031 @default.
- W2744331948 hasConceptScore W2744331948C153911025 @default.
- W2744331948 hasConceptScore W2744331948C170493617 @default.
- W2744331948 hasConceptScore W2744331948C179437574 @default.
- W2744331948 hasConceptScore W2744331948C185592680 @default.