FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744380453> ?p ?o ?g. }

• W2744380453 endingPage "14475" @default.
• W2744380453 startingPage "14469" @default.
• W2744380453 abstract "Abstract The CXCR4 chemokine receptor plays a key regulatory role in many biological functions, including embryonic development and controlling leukocyte functions during inflammation and immunity. CXCR4 has been also associated with multiple types of cancers where its overexpression/activation promotes metastasis, angiogenesis, and tumor growth and/or survival. Furthermore, CXCR4 is involved in HIV replication, as it is a co‐receptor for viral entry into host cells. Altogether, these features make CXCR4 a very attractive target for the development of imaging and therapeutic agents. Here, the in vivo evaluation of the MCoTI‐based cyclotide, MCo‐CVX‐5c, for the development of imaging agents that target CXCR4 is reported. Cyclotide MCo‐CVX‐5c is a potent CXCR4 antagonist with a remarkable in vivo resistance to biological degradation in serum. A [ 64 Cu]‐DOTA‐labeled version of this cyclotide demonstrated high and significant uptake in U87‐stb‐CXCR4 tumors compared to the control U87 tumors. Furthermore, protracted imaging studies demonstrated radiotracer retention in the U87‐stb‐CXCR4 tumor at 24 h post injection. Uptake in U87‐stb‐CXCR4 tumors could be blocked by unlabeled MCo‐CVX‐5c, showing high in vivo specificity. These results demonstrate the in vivo specificity and retention of a bioactive molecularly targeted cyclotide and highlight the potential of bioactive cyclotides for the development of new imaging agents that target CXCR4." @default.
• W2744380453 created "2017-08-17" @default.
• W2744380453 creator A5014794283 @default.
• W2744380453 creator A5043410653 @default.
• W2744380453 creator A5062024359 @default.
• W2744380453 creator A5069386815 @default.
• W2744380453 creator A5088043846 @default.
• W2744380453 date "2017-08-03" @default.
• W2744380453 modified "2023-10-12" @default.
• W2744380453 title "In vivo Evaluation of an Engineered Cyclotide as Specific CXCR4 Imaging Reagent" @default.
• W2744380453 cites W1438161774 @default.
• W2744380453 cites W1533229981 @default.
• W2744380453 cites W1607819524 @default.
• W2744380453 cites W1968459688 @default.
• W2744380453 cites W1983851126 @default.
• W2744380453 cites W1989035987 @default.
• W2744380453 cites W1999787339 @default.
• W2744380453 cites W2002403202 @default.
• W2744380453 cites W2006332354 @default.
• W2744380453 cites W2015111956 @default.
• W2744380453 cites W2035469208 @default.
• W2744380453 cites W2037535235 @default.
• W2744380453 cites W2043465498 @default.
• W2744380453 cites W2059410321 @default.
• W2744380453 cites W2059912289 @default.
• W2744380453 cites W2062148688 @default.
• W2744380453 cites W2079145821 @default.
• W2744380453 cites W2101506538 @default.
• W2744380453 cites W2103995972 @default.
• W2744380453 cites W2110836783 @default.
• W2744380453 cites W2111346723 @default.
• W2744380453 cites W2113129967 @default.
• W2744380453 cites W2113472355 @default.
• W2744380453 cites W2115004940 @default.
• W2744380453 cites W2116018770 @default.
• W2744380453 cites W2118185304 @default.
• W2744380453 cites W2120204395 @default.
• W2744380453 cites W2129356845 @default.
• W2744380453 cites W2133985933 @default.
• W2744380453 cites W2137428036 @default.
• W2744380453 cites W2137792756 @default.
• W2744380453 cites W2138610708 @default.
• W2744380453 cites W2140029453 @default.
• W2744380453 cites W2149888039 @default.
• W2744380453 cites W2152129789 @default.
• W2744380453 cites W2156323704 @default.
• W2744380453 cites W2289856430 @default.
• W2744380453 cites W2325132427 @default.
• W2744380453 cites W2410517512 @default.
• W2744380453 cites W2415602059 @default.
• W2744380453 cites W2519129667 @default.
• W2744380453 cites W2528730299 @default.
• W2744380453 cites W2594877435 @default.
• W2744380453 cites W2617572314 @default.
• W2744380453 cites W4231441182 @default.
• W2744380453 cites W4239221283 @default.
• W2744380453 doi "https://doi.org/10.1002/chem.201702540" @default.
• W2744380453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5812345" @default.
• W2744380453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28771849" @default.
• W2744380453 hasPublicationYear "2017" @default.
• W2744380453 type Work @default.
• W2744380453 sameAs 2744380453 @default.
• W2744380453 citedByCount "25" @default.
• W2744380453 countsByYear W27443804532017 @default.
• W2744380453 countsByYear W27443804532019 @default.
• W2744380453 countsByYear W27443804532020 @default.
• W2744380453 countsByYear W27443804532021 @default.
• W2744380453 countsByYear W27443804532022 @default.
• W2744380453 countsByYear W27443804532023 @default.
• W2744380453 crossrefType "journal-article" @default.
• W2744380453 hasAuthorship W2744380453A5014794283 @default.
• W2744380453 hasAuthorship W2744380453A5043410653 @default.
• W2744380453 hasAuthorship W2744380453A5062024359 @default.
• W2744380453 hasAuthorship W2744380453A5069386815 @default.
• W2744380453 hasAuthorship W2744380453A5088043846 @default.
• W2744380453 hasBestOaLocation W27443804532 @default.
• W2744380453 hasConcept C12823836 @default.
• W2744380453 hasConcept C129470790 @default.
• W2744380453 hasConcept C13373296 @default.
• W2744380453 hasConcept C150903083 @default.
• W2744380453 hasConcept C170493617 @default.
• W2744380453 hasConcept C185592680 @default.
• W2744380453 hasConcept C207001950 @default.
• W2744380453 hasConcept C2780394083 @default.
• W2744380453 hasConcept C2780492938 @default.
• W2744380453 hasConcept C29331040 @default.
• W2744380453 hasConcept C502942594 @default.
• W2744380453 hasConcept C55493867 @default.
• W2744380453 hasConcept C86803240 @default.
• W2744380453 hasConcept C98274493 @default.
• W2744380453 hasConceptScore W2744380453C12823836 @default.
• W2744380453 hasConceptScore W2744380453C129470790 @default.
• W2744380453 hasConceptScore W2744380453C13373296 @default.
• W2744380453 hasConceptScore W2744380453C150903083 @default.
• W2744380453 hasConceptScore W2744380453C170493617 @default.
• W2744380453 hasConceptScore W2744380453C185592680 @default.
• W2744380453 hasConceptScore W2744380453C207001950 @default.
• W2744380453 hasConceptScore W2744380453C2780394083 @default.

• next