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• W2744471844 abstract "// Kumar K.J. Senthil 1 , Vani M. Gokila 1,2 and Sheng-Yang Wang 1,2,3 1 Department of Forestry, National Chung Hsing University, Taichung, Taiwan 2 National Chung Hsing University/University of California at Davis, Plant and Food Biotechnology Center, National Chung Hsing University, Taichung, Taiwan 3 Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan Correspondence to: Sheng-Yang Wang, email: // Keywords : antrodin C, Antrodia cinnamomea, high glucose, endothelial cells, senescence, Gerotarget Received : June 21, 2017 Accepted : July 25, 2017 Published : August 04, 2017 Abstract In the present study, we investigated the effects of antrodin C (ADC), a maleimide derivative isolated from mycelia of Antrodia cinnamomea , on high glucose (HG, 30 mM)-accelerated endothelial dysfunction in vitro . HG-induced cytotoxicity in human umbilical vein endothelial cells (HUVECs) was significantly ameliorated by ADC. In addition, treatment with ADC significantly prevented HG-induced senescence, growth arrest at the G 1 -S transition phase and apoptosis in HUVECs. Moreover, the increased level of intracellular reactive oxygen species (ROS) under HG condition was significantly ameliorated by ADC. Further analysis revealed that ADC-mediated anti-oxidant effects were due to up-regulation of cellular anti-oxidant genes, such as HO-1 and NQO-1 via promotion of the transcriptional activity of Nrf2, which was further confirmed by the failure of ADC to protect HUVECs from HG-induced dysfunction under HO-1 inhibition or Nrf2 silencing. Furthermore, hyperosmotic glucose (HOG, 60 mM)-induced uncontrolled production of ROS, rapid apoptotic cell death and HUVEC injury were significantly prevented by ADC, whereas these preventive effects were barely observed in HO-1 inhibited or Nrf2 silenced cells. Taken together, these results suggest that ADC may represent a promising intervention in diabetic-associated cardiovascular diseases by activating the Nrf2-dependent cellular anti-oxidant defense system." @default.
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• W2744471844 date "2017-08-04" @default.
• W2744471844 modified "2023-10-18" @default.
• W2744471844 title "Activation of Nrf2-mediated anti-oxidant genes by antrodin C prevents hyperglycemia-induced senescence and apoptosis in human endothelial cells" @default.
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• W2744471844 doi "https://doi.org/10.18632/oncotarget.19951" @default.
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