Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744524521> ?p ?o ?g. }
- W2744524521 endingPage "a031260" @default.
- W2744524521 startingPage "a031260" @default.
- W2744524521 abstract "Fibroblast growth factor (FGF)23 is a phosphaturic hormone produced by osteocytes and osteoblasts that binds to FGF receptors in the presence of the transmembrane protein αKlotho. FGF23 mainly targets the renal proximal tubule to inhibit calcitriol production and the expression of the sodium/phosphate cotransporters NaPi2a and NaPi2c, thus inhibiting renal phosphate reabsorption. FGF23 also acts on the parathyroid glands to inhibit parathyroid hormone synthesis and secretion. FGF23 regulation involves many systemic and local factors, among them calcitriol, phosphate, and parathyroid hormone. Increased FGF23 is primarily observed in rare acquired or genetic disorders, but chronic kidney disease is associated with a reactional increase in FGF23 to combat hyperphosphatemia. However, high FGF23 levels induce left ventricular hypertrophy (LVH) and are associated with an increased risk of mortality. In this review, we describe FGF23 physiology and the pathological consequences of high or low FGF23 levels." @default.
- W2744524521 created "2017-08-17" @default.
- W2744524521 creator A5019229807 @default.
- W2744524521 creator A5062845949 @default.
- W2744524521 date "2017-08-04" @default.
- W2744524521 modified "2023-10-14" @default.
- W2744524521 title "Biology of Fibroblast Growth Factor 23: From Physiology to Pathology" @default.
- W2744524521 cites W1500101960 @default.
- W2744524521 cites W1519326211 @default.
- W2744524521 cites W1549105976 @default.
- W2744524521 cites W1563425273 @default.
- W2744524521 cites W1571056651 @default.
- W2744524521 cites W1607110200 @default.
- W2744524521 cites W1608625663 @default.
- W2744524521 cites W1870235011 @default.
- W2744524521 cites W1952338989 @default.
- W2744524521 cites W1963306946 @default.
- W2744524521 cites W1965619867 @default.
- W2744524521 cites W1967604492 @default.
- W2744524521 cites W1969718855 @default.
- W2744524521 cites W1970052428 @default.
- W2744524521 cites W1971484061 @default.
- W2744524521 cites W1973274158 @default.
- W2744524521 cites W1974807791 @default.
- W2744524521 cites W1975687058 @default.
- W2744524521 cites W1977585714 @default.
- W2744524521 cites W1977645780 @default.
- W2744524521 cites W1979425916 @default.
- W2744524521 cites W1982290615 @default.
- W2744524521 cites W1983579422 @default.
- W2744524521 cites W1984898235 @default.
- W2744524521 cites W1986017413 @default.
- W2744524521 cites W1988897099 @default.
- W2744524521 cites W1992157366 @default.
- W2744524521 cites W1997012437 @default.
- W2744524521 cites W1998100845 @default.
- W2744524521 cites W1999372562 @default.
- W2744524521 cites W1999892434 @default.
- W2744524521 cites W2000048959 @default.
- W2744524521 cites W2000413455 @default.
- W2744524521 cites W2002223230 @default.
- W2744524521 cites W2002494594 @default.
- W2744524521 cites W2003490678 @default.
- W2744524521 cites W2004167485 @default.
- W2744524521 cites W2004168425 @default.
- W2744524521 cites W2004344897 @default.
- W2744524521 cites W2008101181 @default.
- W2744524521 cites W2008282188 @default.
- W2744524521 cites W2015093334 @default.
- W2744524521 cites W2015668150 @default.
- W2744524521 cites W2017452957 @default.
- W2744524521 cites W2018568080 @default.
- W2744524521 cites W2019253822 @default.
- W2744524521 cites W2019397580 @default.
- W2744524521 cites W2021852822 @default.
- W2744524521 cites W2023446262 @default.
- W2744524521 cites W2023869058 @default.
- W2744524521 cites W2025398227 @default.
- W2744524521 cites W2025952915 @default.
- W2744524521 cites W2035667662 @default.
- W2744524521 cites W2037498463 @default.
- W2744524521 cites W2039049441 @default.
- W2744524521 cites W2040329227 @default.
- W2744524521 cites W2041242683 @default.
- W2744524521 cites W2051959338 @default.
- W2744524521 cites W2053152115 @default.
- W2744524521 cites W2053797304 @default.
- W2744524521 cites W2059022155 @default.
- W2744524521 cites W2060331245 @default.
- W2744524521 cites W2061659182 @default.
- W2744524521 cites W2063210824 @default.
- W2744524521 cites W2064613534 @default.
- W2744524521 cites W2067490907 @default.
- W2744524521 cites W2070912444 @default.
- W2744524521 cites W2077703010 @default.
- W2744524521 cites W2078522380 @default.
- W2744524521 cites W2078730571 @default.
- W2744524521 cites W2079922348 @default.
- W2744524521 cites W2084180690 @default.
- W2744524521 cites W2089363189 @default.
- W2744524521 cites W2090208385 @default.
- W2744524521 cites W2091948921 @default.
- W2744524521 cites W2093187956 @default.
- W2744524521 cites W2094262605 @default.
- W2744524521 cites W2094551185 @default.
- W2744524521 cites W2096378043 @default.
- W2744524521 cites W2099196302 @default.
- W2744524521 cites W2106711282 @default.
- W2744524521 cites W2109177164 @default.
- W2744524521 cites W2109539957 @default.
- W2744524521 cites W2111387279 @default.
- W2744524521 cites W2114360920 @default.
- W2744524521 cites W2114682576 @default.
- W2744524521 cites W2117621745 @default.
- W2744524521 cites W2118662201 @default.
- W2744524521 cites W2120965382 @default.
- W2744524521 cites W2121435915 @default.
- W2744524521 cites W2122045835 @default.