Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744549384> ?p ?o ?g. }
- W2744549384 endingPage "20" @default.
- W2744549384 startingPage "13" @default.
- W2744549384 abstract "Rationale Acute viral respiratory tract infections in children with cystic fibrosis (CF) are known causes of disease exacerbation. The role of viral infections during infancy is, however, less known, although early infancy is thought to be a crucial period for CF disease development. We prospectively assessed symptomatic and asymptomatic viral detection in the first year of life in infants with CF and healthy controls. Methods In a prospective cohort study, we included 31 infants with CF from the Swiss Cystic Fibrosis Infant Lung Development Cohort and 32 unselected, healthy infants from the Basel Bern Infant Lung Development Cohort and followed them throughout the first year of life. Respiratory symptoms were assessed by weekly telephone interviews. Biweekly nasal swabs were analysed for 10 different viruses and two atypical bacteria with real-time seven duplex PCR (CF=561, controls=712). Measurements and results Infants with CF and healthy controls showed similar numbers of swabs positive for virus (mean 42% vs 44%; OR 0.91, 95% CI 0.66 to 1.26, p=0.6). Virus-positive swabs were less often accompanied by respiratory symptoms in infants with CF (17% vs 23%; OR 0.64, 95% CI 0.43 to 0.95, p=0.026). This finding was pronounced for symptomatic human rhinovirus detection (7% vs 11%; OR 0.52, 95% CI 0.31 to 0.9, p=0.02). Conclusions Viral detection is not more frequent in infants with CF and respiratory symptoms during viral detection occur even less often than in healthy controls. It is likely an interplay of different factors such as local epithelial properties and immunological mechanisms that contribute to our findings." @default.
- W2744549384 created "2017-08-17" @default.
- W2744549384 creator A5011791214 @default.
- W2744549384 creator A5018337128 @default.
- W2744549384 creator A5021925671 @default.
- W2744549384 creator A5028016444 @default.
- W2744549384 creator A5029110686 @default.
- W2744549384 creator A5030481529 @default.
- W2744549384 creator A5034108328 @default.
- W2744549384 creator A5058728924 @default.
- W2744549384 creator A5060442315 @default.
- W2744549384 creator A5063752063 @default.
- W2744549384 creator A5067464263 @default.
- W2744549384 creator A5073094634 @default.
- W2744549384 creator A5077871359 @default.
- W2744549384 creator A5079174598 @default.
- W2744549384 creator A5080982400 @default.
- W2744549384 date "2017-08-04" @default.
- W2744549384 modified "2023-10-18" @default.
- W2744549384 title "Respiratory viruses in healthy infants and infants with cystic fibrosis: a prospective cohort study" @default.
- W2744549384 cites W1521277996 @default.
- W2744549384 cites W1882932512 @default.
- W2744549384 cites W1981548256 @default.
- W2744549384 cites W1988327126 @default.
- W2744549384 cites W1989589185 @default.
- W2744549384 cites W2028341547 @default.
- W2744549384 cites W2028631056 @default.
- W2744549384 cites W2038044678 @default.
- W2744549384 cites W2048204433 @default.
- W2744549384 cites W2056291443 @default.
- W2744549384 cites W2057496127 @default.
- W2744549384 cites W2086127242 @default.
- W2744549384 cites W2102517794 @default.
- W2744549384 cites W2104774207 @default.
- W2744549384 cites W2108338542 @default.
- W2744549384 cites W2114212659 @default.
- W2744549384 cites W2115859297 @default.
- W2744549384 cites W2119680872 @default.
- W2744549384 cites W2126117556 @default.
- W2744549384 cites W2128124260 @default.
- W2744549384 cites W2132942986 @default.
- W2744549384 cites W2137539101 @default.
- W2744549384 cites W2138192279 @default.
- W2744549384 cites W2149905331 @default.
- W2744549384 cites W2151828803 @default.
- W2744549384 cites W2156423502 @default.
- W2744549384 cites W2164608995 @default.
- W2744549384 cites W2165048897 @default.
- W2744549384 cites W2166886317 @default.
- W2744549384 cites W2167279949 @default.
- W2744549384 cites W2167324457 @default.
- W2744549384 cites W2172082722 @default.
- W2744549384 cites W2177824614 @default.
- W2744549384 cites W2200578014 @default.
- W2744549384 cites W2250672168 @default.
- W2744549384 cites W2284937227 @default.
- W2744549384 cites W2382223420 @default.
- W2744549384 cites W2411450168 @default.
- W2744549384 cites W2417916097 @default.
- W2744549384 cites W2460448664 @default.
- W2744549384 cites W2517677111 @default.
- W2744549384 doi "https://doi.org/10.1136/thoraxjnl-2016-209553" @default.
- W2744549384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28778921" @default.
- W2744549384 hasPublicationYear "2017" @default.
- W2744549384 type Work @default.
- W2744549384 sameAs 2744549384 @default.
- W2744549384 citedByCount "12" @default.
- W2744549384 countsByYear W27445493842018 @default.
- W2744549384 countsByYear W27445493842019 @default.
- W2744549384 countsByYear W27445493842020 @default.
- W2744549384 countsByYear W27445493842021 @default.
- W2744549384 countsByYear W27445493842022 @default.
- W2744549384 crossrefType "journal-article" @default.
- W2744549384 hasAuthorship W2744549384A5011791214 @default.
- W2744549384 hasAuthorship W2744549384A5018337128 @default.
- W2744549384 hasAuthorship W2744549384A5021925671 @default.
- W2744549384 hasAuthorship W2744549384A5028016444 @default.
- W2744549384 hasAuthorship W2744549384A5029110686 @default.
- W2744549384 hasAuthorship W2744549384A5030481529 @default.
- W2744549384 hasAuthorship W2744549384A5034108328 @default.
- W2744549384 hasAuthorship W2744549384A5058728924 @default.
- W2744549384 hasAuthorship W2744549384A5060442315 @default.
- W2744549384 hasAuthorship W2744549384A5063752063 @default.
- W2744549384 hasAuthorship W2744549384A5067464263 @default.
- W2744549384 hasAuthorship W2744549384A5073094634 @default.
- W2744549384 hasAuthorship W2744549384A5077871359 @default.
- W2744549384 hasAuthorship W2744549384A5079174598 @default.
- W2744549384 hasAuthorship W2744549384A5080982400 @default.
- W2744549384 hasBestOaLocation W27445493841 @default.
- W2744549384 hasConcept C126322002 @default.
- W2744549384 hasConcept C187212893 @default.
- W2744549384 hasConcept C188816634 @default.
- W2744549384 hasConcept C201903717 @default.
- W2744549384 hasConcept C203014093 @default.
- W2744549384 hasConcept C2776012195 @default.
- W2744549384 hasConcept C2776178081 @default.
- W2744549384 hasConcept C2776938444 @default.
- W2744549384 hasConcept C2777014857 @default.