Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744551481> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2744551481 endingPage "299" @default.
- W2744551481 startingPage "293" @default.
- W2744551481 abstract "Interleukin (IL)-38, a member of the IL-1 family, shows high homology to IL-1 receptor antagonist (IL-1Ra) and IL-36 receptor antagonist (IL-36Ra). Its function in interstitial lung disease (ILD) is still unknown.To determine the expression pattern of IL-38 mRNA, a panel of cDNAs derived from various tissues was analyzed by quantitative real-time PCR. Immunohistochemical reactivity with anti-human IL-38 monoclonal antibody (clone H127C) was evaluated semi-quantitatively in lung tissue samples from 12 patients with idiopathic pulmonary fibrosis/usual interstitial pneumonia (IPF/UIP), 5 with acute exacerbation of IPF, and 10 with anticancer drug-induced ILD (bleomycin in 5 and epidermal growth factor receptor-tyrosine kinase inhibitor in 5). Control lung tissues were obtained from areas of normal lung in 22 lung cancer patients who underwent extirpation surgery.IL-38 transcripts were strongly expressed in the lung, spleen, synoviocytes, and peripheral blood mononuclear cells, and at a lower level in pancreas and muscle. IL-38 protein was not strongly expressed in normal pulmonary alveolar tissues in all 22 control lungs. In contrast, IL-38 was overexpressed in the lungs of 4 of 5 (80%) patients with acute IPF exacerbation and 100% (10/10) of the patients with drug-induced ILD. IL-38 overexpression was limited to hyperplastic type II pneumocytes, which are considered to reflect regenerative change following diffuse alveolar damage in ILD.IL-38 may play an important role in acute and/or chronic inflammation in anticancer drug-induced lung injury and acute exacerbation of IPF." @default.
- W2744551481 created "2017-08-17" @default.
- W2744551481 creator A5002252113 @default.
- W2744551481 creator A5019527890 @default.
- W2744551481 creator A5037746646 @default.
- W2744551481 creator A5043936285 @default.
- W2744551481 creator A5045491062 @default.
- W2744551481 creator A5065970034 @default.
- W2744551481 creator A5067255327 @default.
- W2744551481 creator A5076885089 @default.
- W2744551481 creator A5086830418 @default.
- W2744551481 creator A5088225787 @default.
- W2744551481 date "2017-09-01" @default.
- W2744551481 modified "2023-10-03" @default.
- W2744551481 title "Overexpression of IL-38 protein in anticancer drug-induced lung injury and acute exacerbation of idiopathic pulmonary fibrosis" @default.
- W2744551481 cites W1571673987 @default.
- W2744551481 cites W1975587146 @default.
- W2744551481 cites W1976682338 @default.
- W2744551481 cites W1992571318 @default.
- W2744551481 cites W1999807078 @default.
- W2744551481 cites W2040904789 @default.
- W2744551481 cites W2049204810 @default.
- W2744551481 cites W2052414899 @default.
- W2744551481 cites W2052943307 @default.
- W2744551481 cites W2098527471 @default.
- W2744551481 cites W2098796895 @default.
- W2744551481 cites W2115241294 @default.
- W2744551481 cites W2122712858 @default.
- W2744551481 cites W2125241840 @default.
- W2744551481 cites W2145866317 @default.
- W2744551481 cites W2149661971 @default.
- W2744551481 cites W2440054067 @default.
- W2744551481 doi "https://doi.org/10.1016/j.resinv.2017.06.001" @default.
- W2744551481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28942884" @default.
- W2744551481 hasPublicationYear "2017" @default.
- W2744551481 type Work @default.
- W2744551481 sameAs 2744551481 @default.
- W2744551481 citedByCount "28" @default.
- W2744551481 countsByYear W27445514812017 @default.
- W2744551481 countsByYear W27445514812018 @default.
- W2744551481 countsByYear W27445514812019 @default.
- W2744551481 countsByYear W27445514812020 @default.
- W2744551481 countsByYear W27445514812021 @default.
- W2744551481 countsByYear W27445514812022 @default.
- W2744551481 countsByYear W27445514812023 @default.
- W2744551481 crossrefType "journal-article" @default.
- W2744551481 hasAuthorship W2744551481A5002252113 @default.
- W2744551481 hasAuthorship W2744551481A5019527890 @default.
- W2744551481 hasAuthorship W2744551481A5037746646 @default.
- W2744551481 hasAuthorship W2744551481A5043936285 @default.
- W2744551481 hasAuthorship W2744551481A5045491062 @default.
- W2744551481 hasAuthorship W2744551481A5065970034 @default.
- W2744551481 hasAuthorship W2744551481A5067255327 @default.
- W2744551481 hasAuthorship W2744551481A5076885089 @default.
- W2744551481 hasAuthorship W2744551481A5086830418 @default.
- W2744551481 hasAuthorship W2744551481A5088225787 @default.
- W2744551481 hasConcept C126322002 @default.
- W2744551481 hasConcept C142724271 @default.
- W2744551481 hasConcept C2777014857 @default.
- W2744551481 hasConcept C2777405647 @default.
- W2744551481 hasConcept C2777543607 @default.
- W2744551481 hasConcept C2777714996 @default.
- W2744551481 hasConcept C2778341716 @default.
- W2744551481 hasConcept C2781244666 @default.
- W2744551481 hasConcept C2909621147 @default.
- W2744551481 hasConcept C71924100 @default.
- W2744551481 hasConcept C9418649 @default.
- W2744551481 hasConceptScore W2744551481C126322002 @default.
- W2744551481 hasConceptScore W2744551481C142724271 @default.
- W2744551481 hasConceptScore W2744551481C2777014857 @default.
- W2744551481 hasConceptScore W2744551481C2777405647 @default.
- W2744551481 hasConceptScore W2744551481C2777543607 @default.
- W2744551481 hasConceptScore W2744551481C2777714996 @default.
- W2744551481 hasConceptScore W2744551481C2778341716 @default.
- W2744551481 hasConceptScore W2744551481C2781244666 @default.
- W2744551481 hasConceptScore W2744551481C2909621147 @default.
- W2744551481 hasConceptScore W2744551481C71924100 @default.
- W2744551481 hasConceptScore W2744551481C9418649 @default.
- W2744551481 hasIssue "5" @default.
- W2744551481 hasLocation W27445514811 @default.
- W2744551481 hasLocation W27445514812 @default.
- W2744551481 hasOpenAccess W2744551481 @default.
- W2744551481 hasPrimaryLocation W27445514811 @default.
- W2744551481 hasRelatedWork W2011171956 @default.
- W2744551481 hasRelatedWork W2033071947 @default.
- W2744551481 hasRelatedWork W2079501680 @default.
- W2744551481 hasRelatedWork W2134387223 @default.
- W2744551481 hasRelatedWork W2472837931 @default.
- W2744551481 hasRelatedWork W2555905101 @default.
- W2744551481 hasRelatedWork W2765693228 @default.
- W2744551481 hasRelatedWork W3190722030 @default.
- W2744551481 hasRelatedWork W4282914037 @default.
- W2744551481 hasRelatedWork W4304166203 @default.
- W2744551481 hasVolume "55" @default.
- W2744551481 isParatext "false" @default.
- W2744551481 isRetracted "false" @default.
- W2744551481 magId "2744551481" @default.
- W2744551481 workType "article" @default.