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• W274457367 abstract "Objective—To attempt to culture and study articular cartilage biomolecules in Asian elephant. Materials and Methods—Elephant articular cartilages were dissected from knee joint. The explants were then incubated in culture medium containing antibiotics in a humidified incubator with 5% CO2 at 37°C for 3-28 days, under condition of 10 ng/ml IL-1b-induced cartilage degradation, compare to left untreated as control. At the end of incubation, the conditioned media were collected to measure the quantity of hyaluronan (HA), sulfated glycosaminoglycan (s-GAG) and the matrix metalloproteinase-2 (MMP-2) activity by competitive inhibition-based-ELISA, colorimetric dye binding assay and gelatin zymography respectively. The remaining of collagen and uronic acid content in cartilage tissue were investigated by colorimetric dye binding assays. Results—IL-1b treated group showed 74% higher HA release than control (P<0.05) but there was no statistical difference in s-GAG release. MMP-2 activity was found to be 71% lower in IL-1b treated group than in control. The remaining of collagen and uronic acid in the explant tissues tended to be greater in the IL-1b treated group when compared to the control. The explant tissue section stained with Hematoxylin-Eosin and Safranin-O showed no significant difference in chondrocyte number and matrix profile; however, cell size in IL-1b treated group was likely to be bigger than that in the control. Conclusion—The achievement on cartilage explants culture and monitoring the marker substance of articular cartilage degradation provides the academic significance for further investigation of osteoarthritis in elephants." @default.
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• W274457367 date "2012-01-01" @default.
• W274457367 modified "2023-09-27" @default.
• W274457367 title "Catabolism of Asian elephant cartilage matrix biomolecules in explant culture." @default.
• W274457367 hasPublicationYear "2012" @default.
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