FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744657923> ?p ?o ?g. }

• W2744657923 abstract "Herein, we investigated the neurite pathfinding on electrospun microfibers with various fiber densities, diameters, and microbead islands, and demonstrated the development of 3D connected artificial neuronal network within a nanofiber-microbead-based porous scaffold. The primary culture of rat hippocampal embryonic neurons was deposited on geometry-controlled polystyrene (PS) fiber scaffolds while growth cone morphology, neurite outgrowth patterns, and focal adhesion protein expression were cautiously examined by microscopic imaging of immunostained and live neuronal cells derived from actin-GFP transgenic mice. It was demonstrated that the neurite outgrowth was guided by the overall microfiber orientation, but the increase in fiber density induced the neurite path alteration, thus, the reduction in neurite linearity. Indeed, we experimentally confirmed that growth cone could migrate to a neighboring, but, spatially disconnected microfiber by spontaneous filopodium extrusion, which is possibly responsible for the observed neurite steering. Furthermore, thinner microfiber scaffolds showed more pronounced expression of focal adhesion proteins than thicker ones, suggesting that the neuron-microfiber interaction can be delicately modulated by the underlying microfiber geometry. Finally, 3D connected functional neuronal networks were successfully constructed using PS nanofiber-microbead scaffolds where enhanced porosity and vertical fiber orientation permitted cell body inclusion within the scaffold and substantial neurite outgrowth in a vertical direction, respectively." @default.
• W2744657923 created "2017-08-17" @default.
• W2744657923 creator A5025076547 @default.
• W2744657923 creator A5039751586 @default.
• W2744657923 creator A5043683672 @default.
• W2744657923 creator A5065385911 @default.
• W2744657923 date "2017-08-10" @default.
• W2744657923 modified "2023-10-01" @default.
• W2744657923 title "Investigation of neuronal pathfinding and construction of artificial neuronal networks on 3D-arranged porous fibrillar scaffolds with controlled geometry" @default.
• W2744657923 cites W1586736369 @default.
• W2744657923 cites W1971936343 @default.
• W2744657923 cites W1973089587 @default.
• W2744657923 cites W1986225001 @default.
• W2744657923 cites W1994386978 @default.
• W2744657923 cites W1997651801 @default.
• W2744657923 cites W1998849298 @default.
• W2744657923 cites W1999287295 @default.
• W2744657923 cites W2012798595 @default.
• W2744657923 cites W2016616421 @default.
• W2744657923 cites W2017456728 @default.
• W2744657923 cites W2024405375 @default.
• W2744657923 cites W2027323198 @default.
• W2744657923 cites W2032708535 @default.
• W2744657923 cites W2034636584 @default.
• W2744657923 cites W2043226014 @default.
• W2744657923 cites W2043799833 @default.
• W2744657923 cites W2046774273 @default.
• W2744657923 cites W2053114028 @default.
• W2744657923 cites W2054635074 @default.
• W2744657923 cites W2057008414 @default.
• W2744657923 cites W2057989196 @default.
• W2744657923 cites W2070268956 @default.
• W2744657923 cites W2072213371 @default.
• W2744657923 cites W2073627808 @default.
• W2744657923 cites W2081245644 @default.
• W2744657923 cites W2085579863 @default.
• W2744657923 cites W2098153465 @default.
• W2744657923 cites W2098518658 @default.
• W2744657923 cites W2099821568 @default.
• W2744657923 cites W2111411042 @default.
• W2744657923 cites W2125644189 @default.
• W2744657923 cites W2126598930 @default.
• W2744657923 cites W2130358104 @default.
• W2744657923 cites W2143465327 @default.
• W2744657923 cites W2156862232 @default.
• W2744657923 cites W2157248428 @default.
• W2744657923 cites W2279856288 @default.
• W2744657923 cites W2301888714 @default.
• W2744657923 cites W2308013030 @default.
• W2744657923 cites W2313862609 @default.
• W2744657923 cites W2343809842 @default.
• W2744657923 cites W2462083844 @default.
• W2744657923 cites W2591095189 @default.
• W2744657923 cites W2594578159 @default.
• W2744657923 cites W2622593873 @default.
• W2744657923 cites W2736918570 @default.
• W2744657923 doi "https://doi.org/10.1038/s41598-017-08231-3" @default.
• W2744657923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5552865" @default.
• W2744657923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28798490" @default.
• W2744657923 hasPublicationYear "2017" @default.
• W2744657923 type Work @default.
• W2744657923 sameAs 2744657923 @default.
• W2744657923 citedByCount "17" @default.
• W2744657923 countsByYear W27446579232018 @default.
• W2744657923 countsByYear W27446579232019 @default.
• W2744657923 countsByYear W27446579232020 @default.
• W2744657923 countsByYear W27446579232021 @default.
• W2744657923 countsByYear W27446579232022 @default.
• W2744657923 countsByYear W27446579232023 @default.
• W2744657923 crossrefType "journal-article" @default.
• W2744657923 hasAuthorship W2744657923A5025076547 @default.
• W2744657923 hasAuthorship W2744657923A5039751586 @default.
• W2744657923 hasAuthorship W2744657923A5043683672 @default.
• W2744657923 hasAuthorship W2744657923A5065385911 @default.
• W2744657923 hasBestOaLocation W27446579231 @default.
• W2744657923 hasConcept C105702510 @default.
• W2744657923 hasConcept C113246987 @default.
• W2744657923 hasConcept C12554922 @default.
• W2744657923 hasConcept C12820456 @default.
• W2744657923 hasConcept C135903288 @default.
• W2744657923 hasConcept C136229726 @default.
• W2744657923 hasConcept C159985019 @default.
• W2744657923 hasConcept C171250308 @default.
• W2744657923 hasConcept C185592680 @default.
• W2744657923 hasConcept C192562407 @default.
• W2744657923 hasConcept C202751555 @default.
• W2744657923 hasConcept C2776363448 @default.
• W2744657923 hasConcept C2779530196 @default.
• W2744657923 hasConcept C55493867 @default.
• W2744657923 hasConcept C71924100 @default.
• W2744657923 hasConcept C86803240 @default.
• W2744657923 hasConcept C89429830 @default.
• W2744657923 hasConcept C95444343 @default.
• W2744657923 hasConceptScore W2744657923C105702510 @default.
• W2744657923 hasConceptScore W2744657923C113246987 @default.
• W2744657923 hasConceptScore W2744657923C12554922 @default.
• W2744657923 hasConceptScore W2744657923C12820456 @default.
• W2744657923 hasConceptScore W2744657923C135903288 @default.
• W2744657923 hasConceptScore W2744657923C136229726 @default.
• W2744657923 hasConceptScore W2744657923C159985019 @default.

• next