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• W2744710801 endingPage "865" @default.
• W2744710801 startingPage "858" @default.
• W2744710801 abstract "Osteoblasts are mesenchymal cells that play a key role in maintaining bone homeostasis; they are responsible for the production of extracellular matrix proteins, regulation of matrix mineralization, control of bone remodeling and regulate osteoclast differentiation. Osteoblasts have an essential role in the pathogenesis of many bone diseases, particularly osteoporosis. For many decades, the main current available treatments for osteoporosis have been represented by anti-resorptive drugs, such as bisphosphonates, which act mainly by inhibiting osteoclasts maturation, proliferation and activity; nevertheless, in recent years much attention has been paid on anabolic aspects of osteoporosis treatment. Many experimental evidences support the hypothesis of direct effects of the classical anti-resorptive drugs also on osteoblasts, and recent progress in understanding bone physiology have led to the development of new pharmacological agents such as anti-sclerostin antibodies and teriparatide which directly target osteoblasts, inducing anabolic effects and promoting bone formation." @default.
• W2744710801 created "2017-08-17" @default.
• W2744710801 creator A5009763563 @default.
• W2744710801 creator A5018593082 @default.
• W2744710801 creator A5058398490 @default.
• W2744710801 creator A5066931776 @default.
• W2744710801 date "2017-08-08" @default.
• W2744710801 modified "2023-10-17" @default.
• W2744710801 title "Osteoblast as a target of anti-osteoporotic treatment" @default.
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• W2744710801 doi "https://doi.org/10.1080/00325481.2017.1362312" @default.

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