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- W274473560 abstract "Unscheduled DNA synthesis (UDS) was assayed by measuring the uptake of 3H-dT into the nucleic DNA of sperm cells of mice during the meiotic and postmeiotic stages of spermatogenesis. Incorporation of the radioactive compound into the DNA was measured by liquid scintillation counting. UDS was indicated by the statistically significantly higher incorporation of 3H-dT observed in the treated groups after administration of the mutagens methylmethane sulfonate, cyclophosphamide and the immunosuppressive drug azathioprine. Cyclosporin A, also an immunosuppressive drug, caused no effects in this assay, nor did the two hydrazine derivatives endralazine and hydralazine.Key wordsDrug effectsIn vivo mutagenicity test systemGerm cellsUnscheduled DNA synthesisAzathioprineCyclosporin ACyclophosphamideHydralazineMethylmethane sulfonateEndralazine" @default.
- W274473560 created "2016-06-24" @default.
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- W274473560 date "1984-01-01" @default.
- W274473560 modified "2023-09-26" @default.
- W274473560 title "Monitoring Chemically Induced DNA Damage in the Germ Cells of Male Mice" @default.
- W274473560 cites W1988333267 @default.
- W274473560 cites W2050668132 @default.
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- W274473560 doi "https://doi.org/10.1007/978-3-642-69132-4_25" @default.
- W274473560 hasPublicationYear "1984" @default.
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