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• W2744806422 abstract "Abstract To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibody (TPOAb) positivity. Separate-sample instrumental variable analysis with genetic instruments (Mendelian randomization) was used in an extensively genotyped case (n = 64,374)-control (n = 130,681) study, CARDIoGRAMplusC4D. Associations with lipids, diabetes and adiposity were assessed using the Global Lipids Genetics Consortium Results (n = 196,475), the DIAbetes Genetics Replication And Meta-analysis case (n = 34,380)-control (n = 114,981) study, and the Genetic Investigation of ANthropometric Traits (body mass index in 152,893 men and 171,977 women, waist-hip ratio in 93,480 men and 116,741 women). Genetically predicted thyroid function was not associated with IHD (odds ratio (OR) per standard deviation for TSH 1.05, 95% confidence interval (CI) 0.97 to 1.12; for FT4 1.01, 95% CI 0.91 to 1.12; for TPOAb positivity 1.10, 95% CI 0.83 to 1.46) or after Bonferroni correction with risk factors, except for an inverse association of FT4 with low-density lipoprotein-cholesterol. The associations were generally robust to sensitivity analyses using a weighted median method and MR Egger. This novel study provides little indication that TSH, FT4 or TPOAb positivity affects IHD, despite potential effects on its risk factors." @default.
• W2744806422 created "2017-08-17" @default.
• W2744806422 creator A5020377532 @default.
• W2744806422 creator A5036765539 @default.
• W2744806422 date "2017-08-17" @default.
• W2744806422 modified "2023-10-18" @default.
• W2744806422 title "Thyroid function and ischemic heart disease: a Mendelian randomization study" @default.
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• W2744806422 doi "https://doi.org/10.1038/s41598-017-07592-z" @default.
• W2744806422 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5561103" @default.
• W2744806422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28819171" @default.
• W2744806422 hasPublicationYear "2017" @default.
• W2744806422 type Work @default.
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