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• W2744865202 abstract "Much has been learned about the risk of malignant diseases in people with HIV from observational and clinical cohort studies, multicohort and meta analyses, and population-based HIV/AIDS and cancer registry-match studies. Specific cancers have been reported either in excess or deficit in people with HIV, relative to the general population, and studies have quantified changes in those risks over time. Most importantly, since 1996, the use of effective antiretroviral therapy (ART) to control HIV infection has led to a striking reduction in HIV-related mortality. 1 Centers for Disease Control and PreventionHIV mortality through. https://www.cdc.gov/hiv/pdf/library/slidesets/cdc-hiv-mortality.pdfDate: 2014 Google Scholar However, ART does not fully restore host immune status and, despite the decreases in AIDS-defining cancers—most notably Kaposi's sarcoma and non-Hodgkin lymphoma—the incidence of many cancers, especially those which have viral causes such as Kaposi's sarcoma from human herpesvirus 8 and non-Hodgkin lymphoma from the Epstein-Barr virus, remains high. 2 Park LS Tate JP Sigel K et al. Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era: 1997–2012. AIDS. 2016; 30: 1795-1806 Crossref PubMed Scopus (48) Google Scholar , 3 de Martel C Shiels MS Franceschi S et al. Cancers attributable to infections among adults with HIV in the United States. AIDS. 2015; 29: 2173-2181 Crossref PubMed Scopus (72) Google Scholar , 4 Robbins HA Pfeiffer RM Shiels MS Li J Hall HI Engels EA Excess cancers among HIV-infected people in the United States. J Natl Cancer Inst. 2015; 107: 1-8 Google Scholar Furthermore, because people living with HIV increasingly reach the age with the highest rates of cancer but still live with compromised host immunity, greater longevity might increase their cumulative exposure to systemic inflammation, oncogenic viral infections, and carcinogens, as well as the accumulation of somatic mutations and epigenetic changes related to carcinogenesis. Because the total burden and predominant types of cancers are likely to change over time, ongoing surveillance of cancer rates in people with HIV is important. Cancer risk in HIV-infected people in the USA from 1996 to 2012: a population-based, registry-linkage studyFor several virus-related cancers and lung cancer, declining risks over time in HIV-infected people probably reflect the expansion of ART since 1996. Additional efforts aimed at cancer prevention and screening in people with HIV are warranted. Full-Text PDF" @default.
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• W2744865202 date "2017-11-01" @default.
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• W2744865202 title "Cancer risk in people living with HIV" @default.
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• W2744865202 doi "https://doi.org/10.1016/s2352-3018(17)30147-9" @default.
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