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- W2744927462 endingPage "6399" @default.
- W2744927462 startingPage "6391" @default.
- W2744927462 abstract "Skeletal muscle is important for overall functionality and health. Ageing is associated with an accumulation of damage to mitochondrial DNA and proteins. In particular, damage to mitochondrial proteins in skeletal muscle, which is a loss of mitochondrial proteostasis, contributes to tissue dysfunction and negatively impacts systemic health. Therefore, understanding the mechanisms underlying the regulation of mitochondrial proteostasis and how those mechanisms change with age is important for the development of interventions to promote healthy ageing. Herein, we examine how impairment in the selective degradation of damaged/dysfunctional mitochondria through mitophagy may play a central role in the loss of mitochondrial proteostasis in skeletal muscle ageing, as well as its broader implications for systemic health. Further, we explore how stimulating mitophagy through exercise may promote healthy ageing." @default.
- W2744927462 created "2017-08-17" @default.
- W2744927462 creator A5012700012 @default.
- W2744927462 creator A5071697715 @default.
- W2744927462 date "2017-09-24" @default.
- W2744927462 modified "2023-10-18" @default.
- W2744927462 title "Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing" @default.
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- W2744927462 doi "https://doi.org/10.1113/jp274337" @default.
- W2744927462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5638883" @default.
- W2744927462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28795394" @default.
- W2744927462 hasPublicationYear "2017" @default.
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