Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744930295> ?p ?o ?g. }
- W2744930295 endingPage "673" @default.
- W2744930295 startingPage "665" @default.
- W2744930295 abstract "Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. Controlling macrophage conversion into foam cells remains a major challenge for treatment of atherosclerotic diseases. Here, we show that Wip1, a member of the PP2C family of Ser/Thr protein phosphatases, modulates macrophage migration and phagocytosis associated with atherosclerotic plaque formation. Wip1 deficiency increases migratory and phagocytic activities of the macrophage under stress conditions. Enhanced migration of Wip1-/- macrophages is mediated by Rac1-GTPase and PI3K/AKT signalling pathways. Elevated phagocytic ability of Wip1-/- macrophages is linked to CD36 plasma membrane recruitment that is regulated by AMPK activity. Our study identifies Wip1 as an intrinsic negative regulator of macrophage chemotaxis. We propose that Wip1-dependent control of macrophage function may provide avenues for preventing or eliminating plaque formation in atherosclerosis." @default.
- W2744930295 created "2017-08-17" @default.
- W2744930295 creator A5007446038 @default.
- W2744930295 creator A5015264004 @default.
- W2744930295 creator A5023476924 @default.
- W2744930295 creator A5029260906 @default.
- W2744930295 creator A5029615383 @default.
- W2744930295 creator A5049293174 @default.
- W2744930295 creator A5051380367 @default.
- W2744930295 creator A5055286644 @default.
- W2744930295 creator A5063862218 @default.
- W2744930295 creator A5064570295 @default.
- W2744930295 creator A5074181927 @default.
- W2744930295 creator A5074296409 @default.
- W2744930295 creator A5078930714 @default.
- W2744930295 creator A5083828440 @default.
- W2744930295 creator A5083926246 @default.
- W2744930295 date "2017-10-01" @default.
- W2744930295 modified "2023-10-02" @default.
- W2744930295 title "Wip1-dependent modulation of macrophage migration and phagocytosis" @default.
- W2744930295 cites W1598659248 @default.
- W2744930295 cites W1972706930 @default.
- W2744930295 cites W1979346765 @default.
- W2744930295 cites W1982076272 @default.
- W2744930295 cites W1989679396 @default.
- W2744930295 cites W2003206984 @default.
- W2744930295 cites W2009707750 @default.
- W2744930295 cites W2013353779 @default.
- W2744930295 cites W2013718744 @default.
- W2744930295 cites W2013899166 @default.
- W2744930295 cites W2017683461 @default.
- W2744930295 cites W2023849149 @default.
- W2744930295 cites W2023906419 @default.
- W2744930295 cites W2027810531 @default.
- W2744930295 cites W2036145275 @default.
- W2744930295 cites W2044161694 @default.
- W2744930295 cites W2077792958 @default.
- W2744930295 cites W2079724669 @default.
- W2744930295 cites W2084450450 @default.
- W2744930295 cites W2084811906 @default.
- W2744930295 cites W2087856422 @default.
- W2744930295 cites W2094273616 @default.
- W2744930295 cites W2095738477 @default.
- W2744930295 cites W2113934014 @default.
- W2744930295 cites W2137475525 @default.
- W2744930295 cites W2141701591 @default.
- W2744930295 cites W2141914439 @default.
- W2744930295 cites W2141973741 @default.
- W2744930295 cites W2142685635 @default.
- W2744930295 cites W2144181069 @default.
- W2744930295 cites W2156593520 @default.
- W2744930295 cites W2159891552 @default.
- W2744930295 cites W2163788889 @default.
- W2744930295 cites W369547677 @default.
- W2744930295 doi "https://doi.org/10.1016/j.redox.2017.08.006" @default.
- W2744930295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5562178" @default.
- W2744930295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28822916" @default.
- W2744930295 hasPublicationYear "2017" @default.
- W2744930295 type Work @default.
- W2744930295 sameAs 2744930295 @default.
- W2744930295 citedByCount "16" @default.
- W2744930295 countsByYear W27449302952018 @default.
- W2744930295 countsByYear W27449302952019 @default.
- W2744930295 countsByYear W27449302952020 @default.
- W2744930295 countsByYear W27449302952021 @default.
- W2744930295 countsByYear W27449302952022 @default.
- W2744930295 countsByYear W27449302952023 @default.
- W2744930295 crossrefType "journal-article" @default.
- W2744930295 hasAuthorship W2744930295A5007446038 @default.
- W2744930295 hasAuthorship W2744930295A5015264004 @default.
- W2744930295 hasAuthorship W2744930295A5023476924 @default.
- W2744930295 hasAuthorship W2744930295A5029260906 @default.
- W2744930295 hasAuthorship W2744930295A5029615383 @default.
- W2744930295 hasAuthorship W2744930295A5049293174 @default.
- W2744930295 hasAuthorship W2744930295A5051380367 @default.
- W2744930295 hasAuthorship W2744930295A5055286644 @default.
- W2744930295 hasAuthorship W2744930295A5063862218 @default.
- W2744930295 hasAuthorship W2744930295A5064570295 @default.
- W2744930295 hasAuthorship W2744930295A5074181927 @default.
- W2744930295 hasAuthorship W2744930295A5074296409 @default.
- W2744930295 hasAuthorship W2744930295A5078930714 @default.
- W2744930295 hasAuthorship W2744930295A5083828440 @default.
- W2744930295 hasAuthorship W2744930295A5083926246 @default.
- W2744930295 hasBestOaLocation W27449302951 @default.
- W2744930295 hasConcept C104317684 @default.
- W2744930295 hasConcept C160448771 @default.
- W2744930295 hasConcept C170493617 @default.
- W2744930295 hasConcept C185592680 @default.
- W2744930295 hasConcept C202751555 @default.
- W2744930295 hasConcept C203014093 @default.
- W2744930295 hasConcept C2776914184 @default.
- W2744930295 hasConcept C2777895019 @default.
- W2744930295 hasConcept C2779244956 @default.
- W2744930295 hasConcept C2779828298 @default.
- W2744930295 hasConcept C54166955 @default.
- W2744930295 hasConcept C55493867 @default.
- W2744930295 hasConcept C62478195 @default.
- W2744930295 hasConcept C6929976 @default.