Matches in SemOpenAlex for { <https://semopenalex.org/work/W2744935876> ?p ?o ?g. }
- W2744935876 abstract "Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early life promotes resilience to depression- and anxiety-like behaviors in adulthood. However, the role of PCMS in associated memory process is still unclear. In the present study, we found that adolescent PCMS facilitated extinction and inhibited fear response in reinstatement and spontaneous recovery tests in adult rats, and this effect was still present 1 week later. PCMS in adolescence increased the activity of brain-derived neurotrophic factor (BDNF)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in infralimbic cortex (IL) but not prelimbic cortex in adulthood. Intra-IL infusion of BDNF antibody and the ERK1/2 inhibitor U0126 reversed PCMS-induced enhancement of fear extinction. Moreover, we found that PCMS decreased DNA methylation of the Bdnf gene at exons IV and VI and elevated the mRNA levels of Bdnf in the IL. Our findings indicate that adolescent PCMS exposure promotes fear memory extinction in adulthood, which reevaluates the traditional notion of adolescent stress." @default.
- W2744935876 created "2017-08-17" @default.
- W2744935876 creator A5005240419 @default.
- W2744935876 creator A5006984203 @default.
- W2744935876 creator A5014112819 @default.
- W2744935876 creator A5015865208 @default.
- W2744935876 creator A5018214101 @default.
- W2744935876 creator A5030426436 @default.
- W2744935876 creator A5037853238 @default.
- W2744935876 creator A5044729432 @default.
- W2744935876 creator A5050694337 @default.
- W2744935876 creator A5057835697 @default.
- W2744935876 creator A5063253432 @default.
- W2744935876 creator A5072086960 @default.
- W2744935876 creator A5079620519 @default.
- W2744935876 creator A5085313043 @default.
- W2744935876 date "2017-08-10" @default.
- W2744935876 modified "2023-10-16" @default.
- W2744935876 title "Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood" @default.
- W2744935876 cites W104559480 @default.
- W2744935876 cites W1521749064 @default.
- W2744935876 cites W1549027883 @default.
- W2744935876 cites W1965636455 @default.
- W2744935876 cites W1967473656 @default.
- W2744935876 cites W1969202258 @default.
- W2744935876 cites W1979526394 @default.
- W2744935876 cites W1979978981 @default.
- W2744935876 cites W1985645068 @default.
- W2744935876 cites W1986317069 @default.
- W2744935876 cites W1987375729 @default.
- W2744935876 cites W1989045560 @default.
- W2744935876 cites W1989085266 @default.
- W2744935876 cites W1990217491 @default.
- W2744935876 cites W1990907937 @default.
- W2744935876 cites W1991170680 @default.
- W2744935876 cites W1996092905 @default.
- W2744935876 cites W1996620918 @default.
- W2744935876 cites W1997591796 @default.
- W2744935876 cites W2000079550 @default.
- W2744935876 cites W2000209446 @default.
- W2744935876 cites W2000793737 @default.
- W2744935876 cites W2004304018 @default.
- W2744935876 cites W2005730278 @default.
- W2744935876 cites W2010050518 @default.
- W2744935876 cites W2037387603 @default.
- W2744935876 cites W2039148083 @default.
- W2744935876 cites W2039543325 @default.
- W2744935876 cites W2041329554 @default.
- W2744935876 cites W2044183295 @default.
- W2744935876 cites W2045735318 @default.
- W2744935876 cites W2050237761 @default.
- W2744935876 cites W2050836998 @default.
- W2744935876 cites W2052750950 @default.
- W2744935876 cites W2052963268 @default.
- W2744935876 cites W2055483044 @default.
- W2744935876 cites W2057415261 @default.
- W2744935876 cites W2061322546 @default.
- W2744935876 cites W2062772815 @default.
- W2744935876 cites W2063359051 @default.
- W2744935876 cites W2067004457 @default.
- W2744935876 cites W2067843226 @default.
- W2744935876 cites W2069416181 @default.
- W2744935876 cites W2070785687 @default.
- W2744935876 cites W2071580102 @default.
- W2744935876 cites W2073927880 @default.
- W2744935876 cites W2076818546 @default.
- W2744935876 cites W2085078916 @default.
- W2744935876 cites W2087082832 @default.
- W2744935876 cites W2087381902 @default.
- W2744935876 cites W2092765329 @default.
- W2744935876 cites W2098070616 @default.
- W2744935876 cites W2102038155 @default.
- W2744935876 cites W2115871268 @default.
- W2744935876 cites W2119279206 @default.
- W2744935876 cites W2121984222 @default.
- W2744935876 cites W2122546772 @default.
- W2744935876 cites W2122602360 @default.
- W2744935876 cites W2130743873 @default.
- W2744935876 cites W2137372228 @default.
- W2744935876 cites W2140201388 @default.
- W2744935876 cites W2141747781 @default.
- W2744935876 cites W2144586633 @default.
- W2744935876 cites W2145413665 @default.
- W2744935876 cites W2145674449 @default.
- W2744935876 cites W2148337554 @default.
- W2744935876 cites W2152059360 @default.
- W2744935876 cites W2152656267 @default.
- W2744935876 cites W2153795414 @default.
- W2744935876 cites W2160383565 @default.
- W2744935876 cites W2160621075 @default.
- W2744935876 cites W2162894081 @default.
- W2744935876 cites W2166370054 @default.
- W2744935876 cites W2195043347 @default.
- W2744935876 cites W2312199390 @default.
- W2744935876 cites W2579544063 @default.
- W2744935876 cites W2593517325 @default.
- W2744935876 cites W4242124043 @default.
- W2744935876 cites W4247904703 @default.
- W2744935876 cites W4254108335 @default.
- W2744935876 cites W580921785 @default.