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• W2744937057 abstract "We report the first electrochemical cisplatin sensor fabricated with a thiolated and methylene blue (MB)-modified oligo-adenine (A)-guanine (G) DNA probe. Depending on the probe coverage, the sensor can behave as a signal-off or signal-on sensor. For the high-coverage sensor, formation of intrastrand Pt(II)-AG adducts rigidifies the oligo-AG probe, resulting in a concentration-dependent decrease in the MB signal. For the low-coverage sensor, the increase in probe-to-probe spacing enables binding of cisplatin via the intrastrand GNG motif (N = A), generating a bend in the probe which results in an increase in the MB current. Although both high-coverage signal-off and low-coverage signal-on sensors are capable of detecting cisplatin, the signal-on sensing mechanism is better suited for real time analysis of cisplatin. The low-coverage sensor has a lower limit of detection, wider optimal AC frequency range, and faster response time. It has high specificity for cisplatin and potentially other Pt(II) drugs and does not cross-react with satraplatin, a Pt(IV) prodrug. It is also selective enough to be employed directly in 50% saliva and 50% urine. This detection strategy may offer a new approach for sensitive and real time analysis of cisplatin in clinical samples." @default.
• W2744937057 created "2017-08-17" @default.
• W2744937057 creator A5002360718 @default.
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• W2744937057 date "2017-08-25" @default.
• W2744937057 modified "2023-10-03" @default.
• W2744937057 title "Tunable Signal-Off and Signal-On Electrochemical Cisplatin Sensor" @default.
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• W2744937057 doi "https://doi.org/10.1021/acs.analchem.7b02353" @default.
• W2744937057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28799328" @default.
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